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etic models of antibiotics prescribed in adult CF patients, effectively proposing relevant information for clinicians and researchers to optimize antibiotic therapy in CF.

Levetiracetam has been widely used as a treatment option for different types of epilepsy in both adults and children. Because of its large between-subject variability, several population pharmacokinetic studies have been performed to identify its pharmacokinetic covariates, and thus facilitate individualised therapy.

The aim of this review was to provide a synopsis for population pharmacokinetic studies of levetiracetam and explore the identified influencing covariates.

We systematically searched the PubMed and Embase databases from inception to 30 June 2020. The information on study designs, target population, model characteristics, and identified covariates was summarised. Moreover, the pharmacokinetic profiles were compared among neonates, children, and adults.

Fourteen studies were included, among which two involved neonates, four involved children, two involved both children and adults, and six involved adults only. The median value of apparent clearance for children (0.074 L/h/kg [range 0.038-0.079]) was higher than that for adults (0.054 L/h/kg [range 0.039-0.061]). Body weight was found to significantly influence the apparent clearance and volume of distribution, whereas renal function influenced the clearance. Likewise, coadministration with enzyme-inducing antiepileptic drugs (such as carbamazepine and phenytoin) increased the drug clearance by 9-22%, whereas coadministration with valproate acid decreased it by 18.8%.

Levetiracetam dose regimen is dependent on the body size and renal function of patients. Further studies are needed to evaluate levetiracetam pharmacokinetics in neonates and pregnant women.

Levetiracetam dose regimen is dependent on the body size and renal function of patients. Further studies are needed to evaluate levetiracetam pharmacokinetics in neonates and pregnant women.This work seeks to perform a baseline study to determine the implementation area for a management system of oily waste generated by artisanal fishing boats within the Peruvian context. This explanatory study, conducted based on quantitative and cross-sectional considerations, includes a regulatory review; content analysis of polynuclear aromatic hydrocarbons (PAH) and total petroleum hydrocarbons (TPH) both in seawater and sediments; and metal assessment in sediments and waste oil, with the corresponding result correlations. In this study, the results reveal that while regulations are adequate, their implementation is not evident. In addition, no evidence of contamination by PAH and TPH was found. However, traces of metal contamination were found in sediments, and, after being correlated with the metal values from waste oil, a Spearman's Rho correlation coefficient of 0.619480 was reported. Hence, we can conclude that the regulations to prevent marine pollution from oily waste contained in the International Convention for the Prevention of Pollution from Ships MARPOL agreement have been accepted and approved for implementation. In fact, they can even be applied to different activities that fall out of the scope of the agreement. Finally, the baseline study reveals oily waste generation indicators, as well as a correlation between waste oil metals and marine sediment metals that merits the implementation of an oily waste management system within the study area.In the twenty-first century, the collaboration of control engineering and the healthcare sector has matured to some extent; however, the future will have promising opportunities, vast applications, and some challenges. Due to advancements in processing speed, the closed-loop administration of drugs has gained popularity for critically ill patients in intensive care units and routine life such as personalized drug delivery or implantable therapeutic devices. For developing a closed-loop drug delivery system, the control system works with a group of technologies like sensors, micromachining, wireless technologies, and pharmaceuticals. Recently, the integration of artificial intelligence techniques such as fuzzy logic, neural network, and reinforcement learning with the closed-loop drug delivery systems has brought their applications closer to fully intelligent automatic healthcare systems. This review's main objectives are to discuss the current developments, possibilities, and future visions in closed-loop drug delivery systems, for providing treatment to patients suffering from chronic diseases. ASP2215 in vivo It summarizes the present insight of closed-loop drug delivery/therapy for diabetes, gastrointestinal tract disease, cancer, anesthesia administration, cardiac ailments, and neurological disorders, from a perspective to show the research in the area of control theory.As apex predators, blacktip sharks (Carcharhinus limbatus) are highly susceptible to biomagnified mercury (Hg) particularly in the Gulf of Mexico (GOM), which is known to contain fishes and invertebrates with elevated Hg levels. Blacktip sharks occur in the GOM year-round and are heavily fished both commercially and recreationally, but little is known about how Hg affects the species. In this study, blood, muscle, liver, and kidney samples were collected from neonatal (n = 57) and juvenile (n = 13) blacktip sharks in Charlotte Harbor, Florida. Hg concentrations in neonates and juveniles were found to be elevated in muscle (mean ± SE = 0.59 ± 0.23 mg kg-1), liver (0.39 ± 0.29 mg kg-1), kidney (0.56 ± 0.25 mg kg-1), and blood (0.059 ± 0.041 mg kg-1) compared to other local shark species and conspecifics from other areas. Blood plasma chemistry, hematology, and liver histology were evaluated to assess the relationship between Hg and tissue damage. Plasma chemistry parameters alanine aminotransferase (ALT) and phosphorus (PHOS) were not correlated with tissue Hg or liver condition index. Hematological effects were also not correlated with tissue Hg. However, melanomacrophage presence and lipid deposition, evaluated as part of histopathological analysis, were found to exhibit a statistically significant association with concentrations of Hg in tissue and ALT levels. These results suggest that Hg exposure potentially had a negative effect on the livers of the blacktip sharks evaluated in the present study.