Hovebentley7167
, Citrobacter spp., Acinetobacter spp., and Enterococcus spp. RGDyK chemical structure The overall proportion of extended spectrum beta-lactamase (ESBL) production among Enterobacteriaceae was 31.5% and of methicillin-resistance in Staphylococcus aureus (MRSA) 14.9%. Vancomycin resistance was observed in 5.2% of isolated enterococci (VRE). Resistance to third-generation cephalosporins was observed in 12.7% E.coli isolates and was in 11.2% K. pneumoniae isolates. Carbapenem resistance was identified in 24.7% of P.aeruginosa isolates and 59.3% of Acinetibacter spp. isolates.
Conclusions In a hospital rooms, patient environmental surfaces can be a vehicle for the transmission of multidrug-resistant (MDR) bacterial agents that cause healthcare-associated infections.
Conclusions In a hospital rooms, patient environmental surfaces can be a vehicle for the transmission of multidrug-resistant (MDR) bacterial agents that cause healthcare-associated infections.
The aim To estimate type 2 diabetes mellitus (T2DM) prevalence in patients who came for a consultation to the private practice cardiologist.
Materials and methods 97 patients with cardiovascular diseases (СVD), visited a cardiologist in private medical center, were included (mean age 49,5 (42,8; 58,3) years, 43 (44.3 %) males) and T2DM prevalence was estimated.
Results 84 (86.6 %) patients had arterial hypertension, 19 patients (19.6 %) had coronary artery disease. Mean body mass index was 29,4 (25,2; 33,4) kg/m2. Waist circumference above recommended was observed in 78.4 %. 30 рatients (30.9 %) were overweight, 44.3 % had abdominal obesity. Almost all patients had atherogenic dyslipidemia. Total T2DM prevalence was 19.6 %, including cases of first-diagnosed diabetes (17.5 %).
Conclusions T2DM and prediabetes prevalence in our sample of patients with CVD was higer than described for the general population. Рatients with cardiovascular diseases require careful assessment of diabetes risk factors for its timely detection and for possiblу improving the outcomes.
Conclusions T2DM and prediabetes prevalence in our sample of patients with CVD was higer than described for the general population. Рatients with cardiovascular diseases require careful assessment of diabetes risk factors for its timely detection and for possiblу improving the outcomes.
The aim To evaluate the dynamics of the interferon and collagen-IV systems in bronchoalveolar lavage in the treatment of chronic obstructive pulmonary disease using the tiotropium bromide medication.
Materials and methods The study involved 60 COPD patients with bronchial obstruction of the II degree before and on days 30 and 60 of therapy using conventional treatment regimens and inhalations of tiotropium bromide a the dose of 18 mcg once a day. The collagen-IV levels in bronchoalveolar fluid were determined by means of enzyme-linked immunoassay using "StatFax 303 Plus" analyzer and "Biotrin Collagen IV EIA" reagents. The level of IFN-γ was identified with the help of enzyme-linked immunoassay using "StatFax 303 Plus" analyzer and "ProKon" reagents (LLC "Protein Contour", Russia) in bronchoalveolar fluid obtained during fiber-optic bronchoscopy.
Results When examining Group I patients on the 30th day we found out that the content of collagen-IV in the bronchoalveolar fluid had decreased by only 10.29% ent as compared to the initial indices. The most favorable dynamics of IFN-γ levels in bronchoalveolar contents was observed in Group III patients, and at the time of observation it made up (1.16 ± 0.08) pg/ml, having 2 times (p<0.05) increased as compared to the initial indices. However, in contrast to those taking tiotropium bromide, we examined 12 patients from Group I on the 60th day of treatment and found no significant positive dynamics of IFN-γ content in bronchoalveolar fluid as compared to the indices obtained on day 30.
Conclusions The obtained findings indicate the effect of tiotropium bromide on the reduction of interferon-γ and reduce of collagen-IV levels, which depend on the duration of its use.
Conclusions The obtained findings indicate the effect of tiotropium bromide on the reduction of interferon-γ and reduce of collagen-IV levels, which depend on the duration of its use.
The aim Was assessment of the neurophysiological data and features of clinical picture in patients with neurogenic thoracic outlet syndrome (TOS).
Materials and methods 103 patients with upper extremity pain and/or paresthesia or hypotrophy, or a combination of these symptoms were examined. The examination algorithm included cervical spine radiography, cervical spine and brachial plexuses magnetic resonance imaging (MRI), upper extremity soft tissues and vessels ultrasonic examination, stimulation electroneuromiography with F-waves registration.
Results Neurogenic TOS was diagnosed in 29 patients. A significant relationship between the following complaints and neurophysiological parameters was observed pain, numbness during physical activity and decreased medial anrebrachial cutaneous nerve response amplitude by ≥25% compared to the contralateral side; hypothenar hypotrophy and decrease of ulnar nerve motor/sensory response amplitude; the 4-5th fingers hypoesthesia and decrease of ulnar nerve sensory response amplitude.
Conclusions Medial antebrachial cutaneous nerve amplitudes asymmetry indices of ≥25% or lack of response may be considered to be a marker of true neurogenic TOS.
Conclusions Medial antebrachial cutaneous nerve amplitudes asymmetry indices of ≥25% or lack of response may be considered to be a marker of true neurogenic TOS.
The aim To investigate the prevalence of antibiotic-resistant strains from the association of E. coli - E. faecalis in the urogenital tract of pregnant women.
Materials and methods Used bacteriological method of sectoral culture of urine on nutrient media and identification of strains to the species. The susceptibility of strains to antibiotics was determined by disk-diffusion method, the interpretation of results - according to current EUCAST recommendations. Statistical processing was performed in MS Excel (Analysis of variance (ANOVA)).
Results The number of resistant to cefuroxime, cephalexin, nitrofurantoin, norfloxacin and trimethoprim uropathogenic strains of Escherichia coli does not change depending on the monostrain and associated strain of E. coli from the urine of pregnant women in Dnipro. It was found that the differences in the number of fosfomycin-resistant uropathogenic strains of E. coli depending on the type of culture - the number of fosfomycintolerant urostrains E. coli is 2 times higher among the associated strains, compared with monostains of the studied microorganism. The number of uropathogenic strains of E. faecalis resistant to ampicillin, trimethoprim, nitrofurantoin and norfloxacin does not change depending on the type of culture isolated from the urine of pregnant women in Dnipro.
Conclusions The symbiotic type of existence of two representatives of the normal intestinal flora on the uroepithelium of pregnant women may be associated with the development of Escherichia coli antibiotic resistance only to fosfomycin compared with monoinfection caused by each of these microorganisms.
Conclusions The symbiotic type of existence of two representatives of the normal intestinal flora on the uroepithelium of pregnant women may be associated with the development of Escherichia coli antibiotic resistance only to fosfomycin compared with monoinfection caused by each of these microorganisms.
The aim To evaluate the pathomorphological features of the esophageal mucous membrane in young people with GERD and autoimmune thyroiditis.
Materials and methods 120 patients with GERD and AIT and 45 people with isolated GERD matched for age, gender and social status were examined. Esophagogastroduodenoscopy, histological study and comparative morphometry of the esophageal mucosa were performed.
Results The frequency of erosive GERD in the examined groups of patients did not statistically differ. At the same time, integral analysis of the structure of erosive forms of GERD revealed statistically significant redistribution of grades of esophagitis towards its enhancement in patients with comorbid pathology. The histological study showed that in patients with GERD and AIT all the morphometric parameters studied had a significantly more severe course and exceeded similar indicators of the group with isolated GERD epithelium total thickness, epithelium basal layer thickness, connective tissue papillae height, intercellular space. The analysis of morphological changes frequency showed that epithelium basal layer hyperplasia, dystrophic changes and epithelial edema, elongation of papillae and dilation of intercellular space were significantly more frequent in the group with comorbid pathology.
Conclusions GERD and euthyroid AIT comorbidity in the student population is accompanied by a statistically significant redistribution of esophagitis grades towards its aggravation. The presence of concomitant euthyroid AIT in patients with non-erosive GERD leads to statistically more pronounced disorganization of esophageal mucosal epithelium.
Conclusions GERD and euthyroid AIT comorbidity in the student population is accompanied by a statistically significant redistribution of esophagitis grades towards its aggravation. The presence of concomitant euthyroid AIT in patients with non-erosive GERD leads to statistically more pronounced disorganization of esophageal mucosal epithelium.
The aim To study the value of C-reactive protein in the experimental animals blood serum with bacterial-immune periodontitis and its correction with quercetin.
Materials and methods Modeling of periodontitis was performed by the following method after thiopental anesthesia (at a dose of 40 mg / kg intramuscularly) rats were fixed. A subcostal injection of 0.01 ml of egg protein with cultures of Streptococcus hemolytic and Staphylococcus aureus at a dose of 4 CFU was performed in the area of periodontal tissues of the lower incisor as an initiating inflammatory factor. To enhance the immune process, a complete Freund's adjuvant was introduced into the animal's hind limb at the same time.
Results Analysis of the results of the study of the content of C-reactive protein in the blood serum of animals with experimental bacteria and immune periodontitis, receiving injections of quercetin, showed a significant decrease by 1.31 times, compared with animals with this simulated pathology on the 14th day of the extitis.
The aim of the study was on the basis of the study of clinical manifestations and mechanisms of the formation of disorders of psychological adaptation among the combatants, to develop the principles and program of their medical and psychological rehabilitation.
Materials and methods The study was attended by 153 people at the sanatorium and resort stage of treatment, of which 98 people were combatants and 55 people were civilians. The study used a set of methods aimed at the study of emotional disorders (HDRS, BDI, Spielberger Scale, "Asthenic state scale"), individual psychological features (Multilevel personal questionnaire "Adaptability," Test questionnaire G. Shmishek, K. Leonhard), features of psychosocial functioning (Mississippian scale of PTSD-military version) and quality of life (WHOQOL-BREF).
Results At the stage of sanatorium treatment of combatants is important readaptation to peaceful living conditions. A clinical and psychological analysis of combatants showed that the presence of experienced state of subjective distress and emotional disorder leads to a decrease in the productivity of adaptation to a stressful event.
