Hovalentin4661

3 procedures. The lowest clearance rates were observed in lower calyx calculi (87.2%) and multiple calyx calculi (83.5%). The overall complication rate was 15.1%, and the most common complication was postoperative fever (9.6%). One patient required blood transfusion, owing to postoperative coagulation disorders induced by urosepsis.Single or staged FURS is a practical treatment option for the renal stones sized 2 to 4 cm with acceptable efficacy and safety. Stone clearance rate of FURS treatment is mainly affected by stone size and location.

Several randomized control trials (RCTs) were conducted to compare microwave ablation (MWA) and radiofrequency ablation (RFA) in the treatment of hepatocellular carcinoma (HCC) over the years. RG108 mouse The purpose of this study was to compare the efficacy of RFA and MWA for early stage HCC.

Studies were systematically searched on Emabse, Ovid Medline, PubMed, and Cochrane Library until March 20, 2020. Continuous variables and dichotomous variables were compared using weighted mean difference (WMD) and odds ratio (OR), respectively. For the comparison of overall survival (OS) and disease-free survival (DFS), the hazard ratio (HR) and 95% confidence interval (CI) were extracted from univariate analysis or survival plots.

A total of 26 studies (5 RCTs and 21 cohorts) with 4396 patients (2393 patients in RFA and 2003 patients in MWA) were included in our study. Of these patients, 47% received treatment under general anesthesia in the MWA group and 84% in the RFA group (OR = 0.529, P < .001). The median ablation time was reduced in the MWA group (12 minutes) compared with RFA group (29 minutes) (WMD = -15.674, P < .001). In total, 17.6% patients exhibited progression during follow-up in the MWA group compared with 19.5% in the RFA group (OR = 0.877, P = .225). No statistically significant differences were observed between MWA and RFA groups in terms of OS and DFS (HR = 0.891 and 1.014, P = .222 and .852, respectively).

MWA exhibited similar therapeutic effects as RFA in the treatment of early stage HCC. Given the shorter ablation time, MWA can be performed under local anesthesia.

MWA exhibited similar therapeutic effects as RFA in the treatment of early stage HCC. Given the shorter ablation time, MWA can be performed under local anesthesia.

As one of the most prominent public health and medical problems, Chronic Obstructive Pulmonary Disease (COPD) has a serious impact on the quality of life of participants and may even be life-threatening. While modern medicine has worked well to alleviate the symptoms of COPD, the current situation with this chronic disease is not encouraging. Lung-spleen qi deficiency syndrome is one of the common forms of COPD and the traditional Chinese medicine formula Modified Shenling Baizhu Powder is very frequently used in the treatment of this syndrome. However, no direct evidence is available to support the efficacy and safety of Modified Shenling Baizhu Powder for COPD treatment.

The study is a prospective, randomized, placebo-controlled, double-blind trial in which 270 eligible participants will be randomly assigned to either the experimental or control group in a 11 ratio. link2 Both groups will receive the standard Western medication. Meanwhile, participants in the experimental group will undergo Modified Shenling hu Powder acts, which may provide reference for the treatment plan of COPD participants.

ChiCTR2000037873, Registered 2 September 2020.

ChiCTR2000037873, Registered 2 September 2020.

This study will systematically synthesize the evidence on the potential association between gastroesophageal reflux disease (GERD) and depression disorder (DD).

We will search the following electronic bibliographic databases PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, the Chinese Bio Medical Literature Database, China National Knowledge Infrastructure (CNKI), the China Science and Technology Journal database (VIP) and Wanfang Data. In addition, ongoing trials will be retrieved from the WHO ICTRP Search Portal, the Chinese Clinical Trial Register and The Clinical Trials Register. Articles related to gastroesophageal reflux disease and depression will be searched. And language and time will be unlimited.

The study will afford additional insight into the investigation the association between GERD and DD.

The results of this study will provide helpful evidence to explore the association between GERD and DD.

INPLASY202090026.

INPLASY202090026.The effect of the afternoon napping duration on the risk of depression has not been well established, particularly with regard to sex and age differences. The present study examines the association between afternoon napping duration and depression stratified by sex and age among Chinese adults aged 45 years or older.The 2011 to 2012 survey of the China Health and Retirement Longitudinal Study was utilized, including 5746 participants. We conducted logistic regression with the overall sample and subjects stratified by sex and age.Elderly men with short napping ( less then 30 minutes) had lower odds of having depression symptoms compared with those with no napping group (OR = 0.66, 95% CI = 0.44-0.97). In addition, the finding indicated that middle-aged women with long napping (≥90 min) had a marginally significant difference than those in reference, which showed a negative effect on depression (OR = 0.72, 95% CI = 0.51-1.01).Our findings revealed that extended daytime napping duration can decrease the risk of depression status among middle and elderly people. Moreover, relevant promotion measures should be adopted, such as a suitable rest environment and regular napping habits. The potential mechanism should be clarified by a longitudinal survey to examine the specific causality.Gestational diabetes mellitus (GDM) is a kind of chronic inflammatory condition with carbohydrate metabolism disorder. Interleukin-1beta (IL-1β) plays an important role in inflammatory response, but its role in GDM development remains unknown. The aim of this study was to analyze the association between Interleukin 1beta (IL1B) rs1143623 and rs16944 polymorphisms and susceptibility to GDM.In total, 300 pregnant women with GDM and 261 healthy pregnant women were included in the study. In both groups, single nucleotide polymorphism (SNP) rs1143623 and rs16944 were analyzed by using snapshot technology. IL-1β serum values were determined by ELISA.Serum IL-1β levels involvement in GDM development. According to the results, we found the association between the IL1B rs1143623 polymorphism and susceptibility to GDM. In further analysis, IL1B rs1143623 GG genotype had a higher level of total cholesterol (TCHO) and lower level of high density lipoprotein (HDL) in GDM patients compared with the CC/GC genotypes. However, there were no statistically significant difference between the GDM and healthy control groups in terms of rs16944 polymorphism.Our results indicated that rs1143623 in IL1B gene may lead to GDM in the southwest of china. However, no significant difference was found between GDM and rs16944. link3 The rs1143623 genotype may significantly impact the fat metabolism, especially the levels of TCHO and HDL. We believe that our findings will contribute to understanding of the etiology and possible novel prognostic markers for GDM.

Total knee arthroplasty is accompanied by moderate to severe postoperative pain. Postoperative pain hampers the functional recovery and lowers patient satisfaction with the surgery. Recently, the adductor canal block (ACB) has been widely used in total knee arthroplasty. However, there is no definite answer as to the location of a continuous block within the ACBs.

Randomized controlled trials about relevant studies were searched in PubMed (1996 to Oct 2019), Embase (1996 to Oct 2019), and Cochrane Library (CENTRAL, Oct 2019).

Five studies involving 348 patients met the inclusion criteria. Pooled data indicated that the proximal ACB was as effective as the distal ACB in terms of total opioid consumption (P = .54), average visual analog scale (VAS) score (P = .35), worst VAS score (P = .19), block success rate (P = .86), and time of catheter insertion (P = .54).

Compared with the distal ACB, the proximal ACB showed similar analgesic efficacy for total opioid consumption, average VAS score, worst VAS score, block success rate, and time of catheter insertion. However, because of the limited number of involved studies, more high-quality studies are needed to further identify the optimal location of the ACB.

Compared with the distal ACB, the proximal ACB showed similar analgesic efficacy for total opioid consumption, average VAS score, worst VAS score, block success rate, and time of catheter insertion. However, because of the limited number of involved studies, more high-quality studies are needed to further identify the optimal location of the ACB.

The reproductive dilemma faced by men has always been the focus of the whole society. Idiopathic asthenozoospermia (AZS), as one of the common causes of male infertility, lack of specific treatment. Traditional Chinese medicine has shown potential benefits in the management of male infertility. Yishentongluo decoction (YSTL) is a representative Chinese herbal formula; however, there is still no rigorous clinical trial supporting its application. Therefore, we designed a randomized controlled trial to evaluate the efficacy and safety of YSTL for patients with idiopathic AZS and explain the possible action mechanisms of YSTL in improving sperm motility.

In this randomized controlled study, a total of 160 eligible patients will be assigned to YSTL group or the Levocarnitine oral solution group in a 11 ratio. The treatment period will be 12 weeks and the follow-up period will last 4 weeks. The primary outcome will be the the progressive (motility), sperm rate (%). Secondary outcomes will include the progressive (motility) + non-progressive (motility) sperm rate(%), total effective sperm count, inner mitochondrial membrane potential (MMP) in spermatozoa, and spouse pregnancy rate (%). Safety outcomes will cover electrocardiogram , blood tests (including blood routine test, hepatic function, and renal function), urine routine test, and stool routine test. The semen parameters, sperm MMP test, and all the safety outcomes will be performed at the baseline, 4th, 8th and 12th week. The pregnancy outcome will be evaluated at 4 weeks after treatment.

This study will provide initial evidence regarding the efficacy and safety of YSTL in the treatment of idiopathic AZS with kidney deficiency and blood stasis pattern. In addition, potential mechanisms of YSTL in improving sperm motility will be explored based on sperm MMP test.

Chinese Clinical Trials Register identifier, ChiCTR2000033290, registered on 26 May 2020.

Chinese Clinical Trials Register identifier, ChiCTR2000033290, registered on 26 May 2020.

Myopia is the most common cause of avoidable visual impairment worldwide, which causes huge economic burden and social burden. There are several ways to treat and reduce myopia, but all have drawbacks; this reality drives us to search for additional effective and low-risk interventions of treatment for myopia. Acupuncture is an ancient therapy with a history of thousands of years and is now widely used in the medical system. Some randomized controlled trials have reported that acupuncture, as an adjuvant therapy, can effectively improve the diopter and vision in the sense of myopic children. Deqi is a long-standing belief to ensure the efficacy of acupuncture in the treatment of myopia, but this belief has not been confirmed by sufficient evidence of randomized controlled trials.

This clinical study is a parallel-group, randomized controlled, and single blind study. Three hundred eligible adolescents will randomly be divided into acupuncture Deqi group, acupuncture without Deqi group, and waiting list group.