Houstonsalomonsen3118

Proteomic and phosphoproteomic studies uncover extensive phosphorylation involving regulating healthy proteins inside developing almond anthers.

EG revealed higher MD (p = 0.001) and MA (p less then 0.001) during the first phase and higher MA (p = 0.001) during the fourth phase in both dominant and non-dominant legs on the sagittal plane. HAs dispersion could be related to the amount of forces acting on knee (first two phases) and knee degeneration (elderly). These results may be used as reference data in further studies on HAs dispersion in presence of knee pathologies or after knee surgery or rehabilitation.The structure of a bone tissue is capable of adapting to mechanical loading through the process of bone remodeling, which is regulated by osteoblasts and osteoclasts. Fluid flow within trabecular porosity under cyclic loading is one of the factors stimulating the biological response of osteoblasts and osteoclasts. However, the relation between loading directions and interstitial fluid flow was seldom studied. In the present study, a finite element model based on micro-computed tomographic reconstructions is built by using a mouse femur. Results from the fluid-solid coupling numerical simulation indicate that the loading in different directions generates a distinct distribution of von Mises stress in the bone matrix and a fluid shear stress (FSS) in the bone marrow. The loading along the physiological direction leads to a more uniform distribution of solid stress and produces an FSS level beneficial to the biological response of osteoblasts and osteoclasts compared with those along the non-physiological direction. There was a minimum threshold line of wall FSS with a specific solid stress at the bone surface, suggesting that the wall FSS is mainly induced by the solid strain. These results may offer fundamental data in understanding the mechanical environment around osteoblasts and osteoclasts and the cellular and molecular mechanisms of mechanical loading-induced bone remodeling.The absence of a standardized method for defining hindfoot bone coordinate systems makes it difficult to compare kinematics results from different research studies. The purpose of this study was to develop a reliable and robust procedure for defining anatomical coordinate systems for the talus and calcaneus. Four methods were evaluated based upon their anatomic consistency across subjects, repeatability, and their correspondence to functional axes of rotation. The four systems consisted of 1) interactively identified bony landmarks, 2) a principal component analysis, 3) automatically identified bony landmarks, and 4) translating the tibial coordinate system to the hindfoot bones. The four systems were evaluated on 40 tali and 40 calcanei. The functional axes of rotation were determined using dynamic biplane radiography to image the hindfoot during gait. Systems 2 and 3 were the most repeatable and consistent due to the lack of operator intervention when defining coordinate systems. None of the coordinate systems corresponded well to functional axes of rotation during gait. System 3 is recommended over System 2 because it more closely mimics established bone angles measured clinically, especially for the calcaneus. This study presents an automated method for defining anatomic coordinate systems in the talus and calcaneus that does not rely on manual placement of markers or fitting of spheres to the bone surfaces which are less reliable due to operator-dependent measurements. Using this automated method will make it easier to compare hindfoot kinematics results across research studies.The sit-to-stand movement can be challenging for people with a transtibial amputation (TTA). The alignment of the prosthesis may influence the movement strategies people with TTA use to transfer from sit-to-stand by affecting foot placement. The purpose of this study was to determine how shifting the prosthetic foot anterior and posterior relative to the socket affects movement strategies used to transfer from sit-to-stand. To aid in interpretation, we compared movement strategies between people with and without TTA. Nine people with TTA and nine sex-, and age-matched non-amputee controls completed five self-paced sit-to-stand trials. Mycophenolic supplier With the posterior alignment, participants with TTA had 1) smaller braking GRF impulse on the prosthetic side and greater impulse on the intact side compared to the anterior alignment, 2) no significant differences between sides, which suggests greater braking impulse symmetry compared to anterior and prescribed alignments, and 3) smaller axial trunk range of motion compared to the prescribed alignment. There were also differences between participants with TTA and controls in braking GRF impulse, knee extension moment, anterior/posterior center of pressure position, and lateral and axial trunk range of motion. Based on these results, shifting the prosthetic foot posterior to the socket may be a useful tool to reduce braking impulse asymmetry and trunk motion in people with TTA during sit-to-stand. Thus, prosthetic alignment can have important implications for the comfort and ability of people with TTA to transfer from sit-to-stand as well as for development of secondary health conditions like low back pain, which is associated with compensatory movements.Abnormal femoral version is a deformity in the angle between the femoral neck and the transcondylar axis of the knee. Mycophenolic supplier Both femoral anteversion and retroversion alter passive and active rotation of the hip and are associated with intra-articular or extra-articular impingement. However, little is known about the effect of abnormal femoral version on intra-articular hip contact stresses. To quantify the effect of femoral version on hip contact stress, five cadaveric pelvis specimens were mechanically tested with a hip-specific Tekscan sensor inserted in the joint space. Specimens were oriented in a heel-strike position and loaded with 1000 N of compressive force. Pressure measurements were recorded by the Tekscan sensor with the femur oriented in 0°, 15°, and 30° of version. At the completion of testing, specimens were locked into place at 0° and post-test CT scans were obtained to register the pressure sensor measurements to the joint anatomy. There were minor changes in contact area ( less then 7%) and translation of the peak contact stress location (8.