Hooperzhu1497

To understand whether using a certain e-cigarette device is more strongly associated with risk of combustible tobacco use among youth.

We conducted multivariable logistic regression analyses using cross-sectional data from 4 samples of youth in Connecticut and California (N=10,482; ages 13-24), separately for each study using the total sample and the sample of past-month e-cigarette users, to understand the association between e-cigarette device type and past-month combustible tobacco use, while controlling for age, sex, race/ethnicity, socioeconomic status, school, and past-month marijuana use. Then, we conducted meta-analyses to calculate pooled associations for adolescents, young adults, and all individuals combined.

Among the total sample, combustible tobacco use was associated with any e-cigarette device use (vs. no e-cigarette use) in the pooled analysis across all studies. Among past-month e-cigarette users, combustible tobacco use across all studies was 15.8%-61.5%. Pooled associations among pas product regulation.

As Clinical Practice Guidelines (CPGs) provide effective guidance for providing medical care for individuals with alcohol use disorder (AUD), the evidence behind them should be robust.

Our primary objective was to critically appraise the methodological and reporting quality of systematic reviews cited within CPGs regarding the treatment of AUD. Our secondary objective was to determine how frequently Cochrane Reviews were cited as justification and to evaluate appraisals between Cochrane and non-Cochrane reviews.

We searched PubMed to identify CPGs for the treatment of AUD published between 2015 and 2021. Systematic reviews included in each CPG were evaluated using the Preferred Reporting Instrument for Systematic Reviews and Meta-Analyses (PRISMA) and a validated quality assessment tool (AMSTAR-2). Additional study characteristics were recorded.

From the screening process, 98 systematic reviews from 6 CPGs met inclusion criteria. PRISMA adherence ranged from 72% to 85% (mean of 79%). AMSTAR-2 adherencre important to strengthening evidence informing CPGs.

Recent evidence suggesting that polysubstance use is the norm rather than the exception highlights the need for a better understanding of interactions amongst the abuse-related effects of commonly co-abused drugs. Synthetic cathinones remain one of the most popular families of novel psychoactive substances and are typically used in preparations containing multiple stimulants. Evaluating the reinforcing effects of drugs under both single-operant procedures and procedures in which alternatives are available can provide a more complete characterization of their reinforcing effects and economic interactions.

These studies utilized a drug-versus-drug choice procedure in 18 male Sprague-Dawley rats to evaluate economic interactions between the synthetic cathinone, MDPV, and cocaine in addition to how a history of concurrent access impacts reinstatement behavior.

When equi-effective doses of MDPV and cocaine were made concurrently available, approximately half of the subjects responded exclusively on the MDPV-ggest that environmental stimuli associated with a particular drug might stimulate class-specific drug-seeking, however, further studies are needed to test the generality of this claim.The airborne transmission of SARS-CoV-2 remains surprisingly controversial; indeed, health and regulatory authorities still require direct proof of this mode of transmission. To close this gap, we measured the viral load of SARS-CoV-2 of an infected subject in a hospital room (through an oral and nasopharyngeal swab), as well as the airborne SARS-CoV-2 concentration in the room resulting from the person breathing and speaking. Moreover, we simulated the same scenarios to estimate the concentration of RNA copies in the air through a novel theoretical approach and conducted a comparative analysis between experimental and theoretical results. Results showed that for an infected subject's viral load ranging between 2.4 × 106 and 5.5 × 106 RNA copies mL-1, the corresponding airborne SARS-CoV-2 concentration was below the minimum detection threshold when the person was breathing, and 16.1 (expanded uncertainty of 32.8) RNA copies m-3 when speaking. The application of the predictive approach provided concentrations metrologically compatible with the available experimental data (i.e. for speaking activity). Thus, the study presented significant evidence to close the gap in understanding airborne transmission, given that the airborne SARS-CoV-2 concentration was shown to be directly related to the SARS-CoV-2 emitted. Moreover, the theoretical analysis was shown to be able to quantitatively link the airborne concentration to the emission.Heteroatom doping is a promising technique to enhance biochar for effective environmental remediation. However, development of electroactive heteroatom-doped biochars, e.g., sulfur-doped biochar, has been hindered due to complex nature of non-stoichiometric biomass-derived carbon and changeable electrochemical state of dopants. Herein, we produced a series of wood waste-derived biochars with customized levels of minerals and redox-active moieties, aiming to unravel the crucial factors for sulfur doping. Calcium (Ca) in biochar was found to preferentially coordinate with sulfur to form inactive inorganic sulfur minerals (i.e., CaSO4 and CaS) with inferior catalytic reactivity. After diminishing the inherent Ca minerals beforehand, we could introduce surface phenoxyl-type radicals (C-O•) and vacancy defects on the biochar to develop an electrophilic C-S-O bonding configuration, which guaranteed a high affinity towards peroxymonosulfate (PMS, 2.08 mM g-1, 30 min) and efficient removal of bisphenol A (BPA, 91.1%, 30 min). Scavenging experiments and in-situ Raman analyses indicated that the epoxide-like C-S-O structure induced nucleophilic addition of PMS to generate surface-bound singlet oxygen (1O2, major) and hydroxyl radicals (•OH, minor) through a preservative and stoichiometric interfacial reaction. Overall, the proposed approach overcomes the major hurdles in science-informed fabrication of sulfur-doped biochar and advances its development for environmental remediation.The spread of antibiotic resistance in the aquatic environment severely threatens the public health and ecological security. This study investigated simultaneously capturing and inactivating/oxidizing the antibiotic resistant bacteria (ARB) and cell-free antibiotic resistance genes (ARGs) in waters by flexibly-functionalized microbubbles. The microbubbles were obtained by surface-modifying the bubbles with coagulant (named as coagulative colloidal gas aphrons, CCGAs) and further encapsulating ozone in the gas core (named as coagulative colloidal ozone aphrons, CCOAs). CCGAs removed 92.4-97.5% of the sulfamethoxazole-resistant bacteria in the presence of dissolved organic matter (DOM), and the log reduction of cell-free ARGs (particularly, those encoded in plasmid) reached 1.86-3.30. LF3 molecular weight The ozone release from CCOAs led to efficient in-situ oxidation 91.2% of ARB were membrane-damaged and inactivated. In the municipal wastewater matrix, the removal of ARB increased whilst that of cell-free ARGs decreased by CCGAs with the DOM content increasing. The ozone encapsulation into CCGAs reinforced the bubble performance. The predominant capture mechanism should be electrostatic attraction between bubbles and ARB (or cell-free ARGs), and DOM enhanced the sweeping and bridging effect. The functionalized microbubble technology can be a promising and effective barrier for ARB and cell-free ARGs with shortened retention time, lessened chemical doses and simplified treatment unit.Plastic-derived pollutants are hazardous and pervasive in the environment, and their detection is a challenge due to observational constraints of various dimensions. Physical, chemical, thermal, and spectroscopic methods are extensively used to identify microplastics in environmental systems, but fundamental challenges exist in the isolation and analysis of nanoplastics from environmental samples. The promising practices are often destructive, rendering the samples inutile for further investigations. In this paper, a technique based on the measurement of the dielectric properties of the samples, carried out using the rectangular cavity perturbation technique at the S-band of microwave frequency of 2-4 GHz is proposed. The ability of this method to identify some of the most abundant types of plastics found in the environment, polypropylene, low-density polyethylene, high-density polyethylene, and cross-linked polyethylene, is demonstrated. Electrical characteristics at microwave frequencies such as absorption factor, dielectric constant, and dielectric loss tangent are found useful in the identification of various polymers in the samples. Further, this method can be applied to identify other environmentally stable performance and engineering polymers, which are not often investigated in the environmental matrices for their hazardous effects. This non-destructive measurement method is quick and straightforward and can be further developed to identify a wide range of plastic materials present in various environmental compartments.Information on the occurrence of PFAS in aquatic matrices of countries with no PFAS manufacturing, e.g., New Zealand, is limited. Also, the fingerprint of PFAS along an urban water cycle, following water path from wastewater treatment plant (WWTP) effluent to treated drinking water has not been widely assessed. Hence, 38 long-, short-, ultrashort-chain PFAS and fluorinated alternatives (including precursors) were monitored in this study by collecting composite samples from two urban WWTPs of New Zealand and grab samples from the water bodies receiving the WWTPs' effluents and a drinking water treatment plant, whose source water received the effluent of one of the studied WWTPs. ∑PFAS at concentrations 0.1 - 13 ng/L were detected in all wastewater samples, including influents and different treatment stages of the two WWTPs (WW1 and WW2). The fate of most PFAS was similar in the two WWTPs, despite large differences in WWTPs' PFAS loads in the influents, serving populations (1.6 vs 0.16 million), total capacitieaters of WW2 implied that other sources, such as septic systems, peripheral industries, and the airport, could also be contributing to PFAS in coastal waters. The source of ultrashort-chain PFPrA (5.5 ng/L) detected in the treated drinking water produced from that river was unclear. The monitoring results confirm incomplete removal of PFAS in WWTPs, indicate a possible transformation of unknown precursors present in wastewater into short-chain perfluoroalkylcarboxylic acids (PFCAs) during biological treatment, and reveal a possible accumulation of perfluoroalkylsulfonic acids (PFSAs) in the sludge, overall suggesting the circulation of PFAS in urban water systems.Cells integrate complex cytokine cues and other inflammatory stimuli through activation of the signal transducers and activators of transcription (STAT) family of transcription factors to drive the appropriate anti-microbial, inflammatory, and resolving functions. Here, we discuss recent progress in our understanding of mechanisms supporting STAT functional diversity. Signaling component availability and the strength of receptor and STAT interactions emerge as important determinants of immune function. The resultant dynamics of STAT activation, together with stimulus-specific variation in STAT post-translationally modified states, will impact downstream binding partners to support transcription of distinct gene subsets. Understanding how context-dependent STAT function is encoded to dictate cytokine specificity, crosstalk, and control of inflammation will guide therapeutic efforts to selectively perturb STAT-regulated responses.