Hongreynolds3789

We have found that the DNA intercalator [Ru(bpy)2DPPZ]2+ (bpy = 2,2'-bipyridine; DPPZ = dipyrido[3,2-a2',3'-c]phenazine) causes an anomalous increase in charge transfer in electrochemical impedance spectroscopy (EIS). With a carbonaceous electrode and a 1 mM hexacyanoferrate (1 mM [Fe(CN)6]3- and 1 mM [Fe(CN)6]4-) mediator, we found that adding only 1 μM [Ru(bpy)2DPPZ]2+ greatly enhanced the charge transfer between the electrode and hexacyanoferrate mediator, independently of other electrolytes or buffer components. The effect started with a one millionth amount of hexacyanoferrate. Since [Ru(bpy)2DPPZ]2+ can intercalate with dsDNA, the effect is highly applicable for dsDNA detection or PCR monitoring. With further developments of this method, EIS sensors not requiring specific electrode modifications should be possible.Current oxidative stress amplifying strategies for immunogenic cell death (ICD) promotion are mainly restricted to immune tolerance induced by adaptive cellular antioxidation, limited tumor-selectivity, and tumoral immunosuppression. Herein, a facile and efficient scenario of genetically engineering transferrin-expressing cell membrane nanovesicle encapsulated IR820-dihydroartemisinin nanomedicine (Tf@IR820-DHA) was developed to boost a-PD-L1-mediated immune checkpoint blocking (ICB) via synergetic triple stimuli-activated oxidative stress-associated ICD. We demonstrate that the engineered transferrin of Tf@IR820-DHA has excellent tumor targeting and Fe(III)-loading properties and thus delivered Fe(III) and IR820-DHA nanoparticles (NPs) to the lesion location effectively. We found that the self-carrying Fe(III)-mediated programmable catalysis of DHA and glutathione (GSH) depletion generated plenty of reactive oxygen species (ROS). Moreover, DHA also acted as an immunomodulator to decrease the number of T regulatory cells, thereby remodeling the tumor immune microenvironment and achieving double T cell activation. Furthermore, the IR820 molecule served as a competent sonosensitizer to produce ROS under ultrasound activation and guide precise immunotherapy via fluorescent/photoacoustic (FL/PA) imaging. Through its three-pronged delivery of stimuli-activated oxidative stress (DHA-induced chemodynamic therapy, catalysis-conferred GSH depletion, and IR820-mediated sonodynamic therapy), Tf@IR820-DHA caused high levels of targeted ICD. This significantly increased the proportions of IFN-γ-secreting T cells (CD4+ T and CD8+ T) and enhanced a-PD-L1-mediated ICB against primary and distant tumors, which represents a promising approach for cancer nanoimmunotherapy.

Bisphenol A (BPA) is a product in the manufacture of Bis-GMA, which is commonly used in dentistry, and is known to have a number of adverse effects.

The aim of this study is to evaluate to assess the knowledge, attitude and practice based on exposure and handling of BPA containing materials among dental surgeons for better understanding about the level of care rendered to the patients.

A questionnaire survey was conducted on 400 dental surgeons in Southern India. The questionnaire consisted of 20 objective type questions out of which ten questions assessed knowledge and five questions assessed the attitude and five questions to understand the practice related measures taken by the dentist. The data collected were analysed using SPSS version 23.

A total of 402 responses were collected for this online questionnaire survey over a period of 2 months. It was found that females showed higher knowledge and attitude towards exposure to BPA which was statistically significant when compared to males. It showed that dentists with more than 20 years of practice had a higher level of knowledge. Though most of the groups agreed fairly on safety practice to be undertaken related to BPA exposure in their clinics, the ones with experience more than 20 years displayed the least positive attitude and dentists with 6-10 years of practice had the least positive behaviour among all.

In spite of having a good knowledge regarding the harmful effects of BPA, dental surgeons are not very cautious while using materials containing them on a regular basis. Therefore, there is a need to enhance the awareness with the help of Continuing Dental Education programs or proper instructions on the packaging.

In spite of having a good knowledge regarding the harmful effects of BPA, dental surgeons are not very cautious while using materials containing them on a regular basis. Therefore, there is a need to enhance the awareness with the help of Continuing Dental Education programs or proper instructions on the packaging.

Excessive heat exposure and dehydration among agricultural workers have been reported to reduce kidney function and lead to chronic kidney disease of unknown etiology (CKDu).

This cross-sectional study aimed to assess heat exposure, factors related to dehydration and the relationship between dehydration and biomarkers of kidney function among sea salt workers in Thailand.

Wet bulb globe temperature (WBGT) was used at the time workers started work outdoors on salt farms. Urine-specific gravity, urine osmolarity, and serum creatinine were collected from 50 workers after work.

The results showed that more than 50% of the participants were dehydrated after work. The maximum hours spent working per day was 10. The average water intake was 1.51 L. Urine specific gravity was highly significant correlated with urine osmolality (rs = 0.400, p<0.01), and urine osmolality was significantly correlated with the estimated glomerular filtration rate (eGFR) (rs = 0.349, p<0.05). In bivariate analysis adjusted for age, sex, and current alcohol consumption, we found that a WBGTTWA ≥ 30°C (OR = 0.08, 95% CI = 0.01-0.44, p = 0.003) and hours spent working (OR=2.22, 95% CI = 1.42-3.47, p <0.001) were independently associated with dehydration. This suggests that workers should increase their time spent on breaks and increase water consumption.

Educational program on heat exposure and heat-related illness prevention strategies should be provided.

Educational program on heat exposure and heat-related illness prevention strategies should be provided.

Low birth weight (LBW) is an important predictor of neonatal morbidity and mortality. It reflects the nutritional status of the mother and the quality of health care services during pregnancy.

The objective of this study is to determine the factors associated with low birth weight of children born to Moroccan pregnant women in the province of El Jadida.

This cross-sectional case-control study was carried out in the maternity ward of El Jadida provincial hospital on 344 parturient women, half of whom had given birth to children with an LBW and the other half of children with normal weight (NW) at birth. Information on maternal gestational and socioeconomic characteristics as well as eating habits was collected using a questionnaire and anthropometric measurements were taken on the newborns.

The study identified 172 parturient who gave birth to newborns with LBW and 172 parturient who gave birth to newborns of NW. The proportions of LBW are greater in first-time mothers (50.6%) and professionally inactideficit.

Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder that is driven by the gutbrain axis and affects 1-20% of the population. Most patients note that various foods elicit abdominal symptoms, and they eliminate these products from their diets. A diet that is low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) is currently one of the mainstays in IBS treatment.

The aim of this study was to assess the knowledge of IBS patients about the disease, treatment and the principles of the low-FODMAP diet that can alleviate gastrointestinal symptoms.

The participants were adults diagnosed with IBS, the inclusion criteria were absence of comorbidities requiring an elimination diet, age over 18 years, and consent to participate in the study. The respondents filled out an anonymous questionnaire containing questions about the IBS diagnosis, disease history and treatment, as well as 45 questions assessing the participants' knowledge about the low-FODMAP diet.

e duration of each dietary phase. Age was significantly correlated with the respondents' knowledge, and the participants' familiarity with low-FODMAP guidelines decreased with age. Nutritional consultations did not significantly improve the respondents' knowledge about the low-FODMAP diet.

The surveyed population was characterized by high levels of knowledge about the low-FODMAP diet, but many respondents did not strictly comply with dietary guidelines, in particular the duration of each dietary phase. Age was significantly correlated with the respondents' knowledge, and the participants' familiarity with low-FODMAP guidelines decreased with age. Nutritional consultations did not significantly improve the respondents' knowledge about the low-FODMAP diet.

Onset of overweight and obesity has been previously reported as a result of population migration to western countries.

To determine the nutritional status, weight status and their association with socioeconomic status in sub-Saharan settled in El Jadida city in a Mediterranean country Morocco.

A descriptive study was carried out in 2018 on 256 sub-Saharans migrants living in the city of El Jadida in Morocco. buy GW5074 Information on socio-economic and socio-demographic characteristics as well as anthropometric measurements was collected. The body mass index (BMI) and abdominal obesity by measuring waist circumference (WC) and waist circumference to hip ratio (WHR) and the distribution of body fat by calculating the sum of skin folds are determined.

Analysis results indicate that height, waist circumference, hip circumference, sum of trunk skinfolds, total sum of skinfolds, and BMI increase with age. The prevalence of underweight decreases with age, overweight was 38.7% in the youngest age group (18-25 years) anity were prevalent among sub-Saharan migrants residing in the city of El Jadida. This prevalence is associated with socio-demographic and socioeconomic factors.

COVID-19 pandemic poses a significant threat in area of public health. In the light of dynamic increase of infections European countries decided to implement special safety measures in order to stop spread of SARS-CoV-2 virus. Reduction of the activity of shopping galleries, grocery stores and gastronomy directly impacted the change of consumer behaviours.

The aim of this research was the analysis of consumer behaviour during COVID-19 pandemic regarding the use of gastronomical services, grocery shopping and undertaken safety measures.

The main instrument was original survey conducted on-line in November 2020. The form consisted of metrics and close-ended questions about consumer behaviour during COVID-19 pandemic. 1080 respondents took part in the study (females - 850; men - 230). Results were mapped out in Statistics 13.1 program and graphical representation was prepared in Microsoft Excel.

More than half of respondents were working people (n=629; 58%). Vast majority of working respondents during the study were working stationary (n=304; 48%), while remotely only 33% (n=208). Among young respondents almost half of the group was unemployed (n=158; 45%), while the rest of the group was employed (n=195; 55%). Professional activities in the group of respondents that were still learning was mostly stationary/ physic (n=57; 29%). During the pandemic the stationary form of working switched into remote in every third of respondent (n=307; 28%).

Global pandemic of COVID-19 forced people to change their current behaviours - both consumer and social. Consumers are aware of risks borne by SARS-CoV-2 infection, which may be concluded from undertaken safety measures.

Global pandemic of COVID-19 forced people to change their current behaviours - both consumer and social. Consumers are aware of risks borne by SARS-CoV-2 infection, which may be concluded from undertaken safety measures.