Holbrookmason2240

Atherosclerosis (AS), an important cause of high mortality of cardiovascular disease, involves numerous pathophysiological processes, including endothelial cell damage, oxidative stress, inflammation, lipid deposition, vascular smooth muscle proliferation and migration, macrophage-derived foam cell formation, and platelet aggregation, and seriously endangers human health and safe of life. Hydrogen sulfide (H2S) was discovered as the third gaseous signaling molecule following nitric oxide (NO) and carbon monoxide (CO), and has been proposed to exert potentially significant effects in many physiological processes, especially in atherosclerosis. Compelling evidence suggests that malfunction of CSE/H2S pathway and downregulation of endogenous H2S level contribute to the pathogenesis of atherosclerosis, whereas exogenous supplementation of H2S can ameliorate many of atherogenic processes. The current knowledge on the anti-atherogenic role of H2S comes from the use of H2S donors and CSE or CBS inhibitors, or another more accurate genetic technology, including gene knockout and gene therapy studies. Among them H2S releasing donors have vast therapeutic potential in anti-atherosclerosis and are promising as one of the clinical strategies for atherosclerosis treatment. Based on the recent studies on therapeutic effects and mechanisms of H2S donors, this review focuses on the most recent advances of therapeutic potential of H2S donors in anti-atherosclerosis, especially synthetic organic donors, because sulfide salts can release H2S rapidly and lead to various adverse effects. In addition, the future of this domain is prospected.

To investigate clinical, radiologic and pathologic features of B3 lesions diagnosed on VABB targeting microcalcifications, for identifying predictors of malignancy.

This retrospective multi-centre study included consecutive VABBs performed over a 10-year period on suspicious microcalcifications not associated with other radiological signs diagnosed as B3 on histology from VABB, with outcomes ascertained by surgical excision. Clinical, demographic, radiological and histological (B3 subcategory) data were collected. For statistical analysis (univariate and binary logistic regression), the primary outcome variable was the upgrade rate to malignancy after surgery. Predictors of upgrade to malignancy were identified from clinical, demographic, radiological and pathological variables (including B3 subcategory).

Amongst 447 VABBs, there were 57(12.7 %) upgrades to malignancy at surgical histology (36 DCIS and 21 invasive cancer). At univariate analysis, variables significantly associated with increased risk ofI-RADS category≥ 4b on imaging, and lobular neoplasia were risk factors for upgrade to malignancy. This information can be used to discuss patients' tailored management options.Evidence from the past shows that pesticide use in populated areas may impact groundwater quality. The approval of herbicides such as diflufenican and glyphosate for use on paved and unpaved gravel surfaces in the European Union is based on their behaviour and fate in agricultural soils. However, this might be very different from their fate in gravel surfaces. We therefore conducted an outdoor study with 21 small lysimeters containing different gravel types and a sandy arable topsoil as control. 3-Methyladenine mouse The lysimeters were sprayed with a commercial product for gardening, containing diflufenican and glyphosate. The concentrations of the herbicides and their relevant degradation products in the outlet was followed for 19 months. Diflufenican, glyphosate and AMPA did not leach from any of the lysimeters. However, one diflufenican degradation product (AE-0) leached from two of the gravel types for more than a year and a second degradation product (AE-B) leached from all gravels for up to one year. Concentrations in the leachate peaked at 0.5-3 μg/L, with highest concentrations over the longest periods observed with rock chippings on top of the gravel. We conclude, that the different properties of gravel compared to those of agricultural soils may lead to very different herbicide leaching patterns but also that the leaching depends highly on the type of gravel and type of herbicide.Microplastics (MPs) have been widely detected in wastewater treatment plants (WWTPs) due to their small particle size, wide distribution, and difficulty in removal. Previous studies, however, mostly focused on MPs in wastewater, thereby neglecting sludge. To comprehensively understand the changes of MPs in WWTPs, we investigated the quantity and characteristics of MPs in wastewater and sludge of a WWTP in Harbin, a typical inland city in China, and calculated the MPs removal rate. The results showed that there were 126.0 ± 14.0 particles/L MPs in the influent and 30.6 ± 7.8 particles/L in the effluent, about 75.7% MPs were removed and transferred to the sludge during this WWTP. The abundance of MPs in dewatered sludge and sludge filter cake was 36.3 ± 5.7 and 46.3 ± 6.2 particles/g (dry sludge), the sludge disposal scale of this WWTP can reach 1300 tons/day, which was equivalent to about 7.74 × 1012 microplastic particles accumulated in sludge per year. These sludges were used as fertilizers in the soil, which will cause secondary pollution of MPs. Raman spectroscopic analysis showed that about 89.5% of particles were plastic polymers, such as polyesters, polyamide (PA), polyethylene terephthalate (PET) and polyethylene (PE), which suggested that MPs may be derived from laundry and personal care products. Therefore, we recommend that more work should be devoted to how to control the release of MPs at the source and the reuse of sludge after treatment by WWTPs.Under the stress of global climate change, soil wind erosion has become a major environmental issue in the Three-River Source Region (TRSR) of China. However, few large-scale studies have been conducted on soil wind erosion owing to the lack of investigational data or complex parameters. Moreover, the uncertainty and randomness in the weight determination process cannot be avoided using the traditional method. Thus, a cloud-analytic hierarchy process (cloud-AHP) model was proposed to construct a wind erosion intensity index model for the TRSR based on seven typical land surface parameters. The following results were obtained. (1) The cloud-AHP model can better eliminate the randomness and uncertainty in the weight determination process. (2) The proposed evaluation method of wind erosion intensity has better applicability in the TRSR with overall accuracy of 93%. (3) The overall wind erosion intensity in this region is moderate. The wind erosion intensity was the largest in the Yangtze River (0.55, moderate erosion) and smallest in the source region of the Lancang River (0.