Hobbsweeks3391
The occurrence of planar hexacoordination is very rare in main group elements. We report here a class of clusters containing a planar hexacoordinate silicon (phSi) atom with the formula SiSb3M3 + (M = Ca, Sr, Ba), which have D 3h (1A1') symmetry in their global minimum structure. The unique ability of heavier alkaline-earth atoms to use their vacant d atomic orbitals in bonding effectively stabilizes the peripheral ring and is responsible for covalent interaction with the Si center. Although the interaction between Si and Sb is significantly stronger than the Si-M one, sizable stabilization energies (-27.4 to -35.4 kcal mol-1) also originated from the combined electrostatic and covalent attraction between Si and M centers. The lighter homologues, SiE3M3 + (E = N, P, As; M = Ca, Sr, Ba) clusters, also possess similar D 3h symmetric structures as the global minima. However, the repulsive electrostatic interaction between Si and M dominates over covalent attraction making the Si-M contacts repulsive in nature. Most interestingly, the planarity of the phSi core and the attractive nature of all the six contacts of phSi are maintained in N-heterocyclic carbene (NHC) and benzene (Bz) bound SiSb3M3(NHC)6 + and SiSb3M3(Bz)6 + (M = Ca, Sr, Ba) complexes. Therefore, bare and ligand-protected SiSb3M3 + clusters are suitable candidates for gas-phase detection and large-scale synthesis, respectively.[This corrects the article DOI 10.1039/D0SC01146K.].Catalytic systems are complex and dynamic, exploring vast chemical spaces on multiple timescales. In this perspective, we discuss the dynamic behavior of fluxional, heterogeneous thermal and electrocatalysts and the ensembles of many isomers which govern their behavior. We develop a new paradigm in catalysis theory in which highly fluxional systems, namely sub-nano clusters, isomerize on a much shorter timescale than that of the catalyzed reaction, so macroscopic properties arise from the thermal ensemble of isomers, not just the ground state. Accurate chemical predictions can only be reached through a many-structure picture of the catalyst, and we explain the breakdown of conventional methods such as linear scaling relations and size-selected prevention of sintering. We capitalize on the forward-looking discussion of the means of controlling the size of these dynamic ensembles. This control, such that the most effective or selective isomers can dominate the system, is essential for the fluxional catalyst to be practicable, and their targeted synthesis to be possible. It will also provide a fundamental lever of catalyst design. Finally, we discuss computational tools and experimental methods for probing ensembles and the role of specific isomers. We hope that catalyst optimization using chemically informed descriptors of ensemble nature and size will become a new norm in the field of catalysis and have broad impacts in sustainable energy, efficient chemical production, and more.The demand for fast-charging metal-ion batteries underlines the importance of anodes that work at high currents with no risk of dendrite formation. NiBTA, a one-dimensional Ni-based polymer derived from benzenetetramine (BTA), is a recently proposed promising material for safe fast-charging batteries. However, its charge-discharge mechanisms remained unclear and controversial. Here we solve the controversies by providing the first rigorous study using a combination of advanced theoretical and experimental techniques, including operando and ex situ X-ray diffraction, operando Raman spectroscopy and ex situ X-ray absorption near-edge spectroscopy (XANES). In safe potential ranges (0.5-2.0 V vs. M+/M, M = Li, Na or K), NiBTA offers high capacities, fast charge-discharge kinetics, high cycling stability and compatibility with various cations (Li+, Na+, K+). In the Na- and K-based cells, fast bulk faradaic processes are manifested for partially reduced states. Atomistic simulations explain the fast kinetics by facile rotations and displacements of the macromolecules in the crystal, opening channels for fast ion insertion. The material undergoes distinct crystal structure rearrangements in the Li-, Na- and K-based systems, which explains different electrochemical features. At the molecular level, the charge storage mechanism involves reversible two-electron reduction of the repeating units accompanied by a change of the absorption bandgap. The reversible reduction involves filling of the orbitals localized at the ligand moieties. No reduction of NiBTA beyond two electrons per repeating unit is observed at potentials down to 0 V vs. M+/M.The most fundamental tasks in asymmetric synthesis are the development of fully stereodivergent strategies to access the full complement of stereoisomers of products bearing multiple stereocenters. Although great progress has been made in the past few decades, developing general and practical strategies that allow selective generation of any diastereomer of a reaction product bearing multiple stereocentres through switching distinct chiral catalysts is a significant challenge. Here, attaining precise switching of the product stereochemistry, we develop a novel P-chirogenic ligand, i.e.YuePhos, which can be easily derived from inexpensive and commercially available starting materials in four chemical operations. selleckchem Through switching of three chiral ligands, an unprecedented ligand-dependent diastereodivergent Pd-catalyzed asymmetric intermolecular [4 + 2] cycloaddition reaction of vinyl benzoxazinanone with α-arylidene succinimides was developed. This novel method provides an efficient route for the stereodivergent synthesis of six stereoisomers of pyrrolidines bearing up to three adjacent stereocenters (one quaternary center). Despite the anticipated challenges associated with controlling stereoselectivity in such a complex system, the products are obtained in enantiomeric excesses ranging up to 98% ee. In addition, the synthetic utilities of optically active hexahydrocarbazoles are also shown.The complex interaction between molecules and catalyst surfaces leads to great difficulties in understanding and predicting the activity and selectivity in heterogeneous catalysis. Here we develop an end-to-end artificial intelligence framework for the activity prediction of heterogeneous catalytic systems (AI-Cat method), which takes simple inputs from names of molecules and metal catalysts and outputs the reaction energy profile from the input molecule to low energy pathway products. The AI-Cat method combines two neural network models, one for predicting reaction patterns and the other for providing the reaction barrier and energy, with a Monte Carlo tree search to resolve the low energy pathways in a reaction network. We then apply AI-Cat to resolve the reaction network of glycerol hydrogenolysis on Cu surfaces, which is a typical selective C-O bond activation system and of key significance for biomass-derived polyol utilization. We show that glycerol hydrogenolysis features a huge reaction network of relevant candidates, containing 420 reaction intermediates and 2467 elementary reactions. Among them, the surface-mediated enol-keto tautomeric resonance is a key step to facilitate the primary C-OH bond breaking and thus selects 1,2-propanediol as the major product on Cu catalysts. 1,3-Propanediol can only be produced under strong acidic conditions and high surface H coverage by following a hydrogenation-dehydration pathway. AI-Cat further discovers six low-energy reaction patterns for C-O bond activation on metals that is of general significance to polyol catalysis. Our results demonstrate that the reaction prediction for complex heterogeneous catalysis is now feasible with AI-based atomic simulation and a Monte Carlo tree search.Intra- and intermolecular interactions are dominating chemical processes, and their concerted interplay enables complex nonequilibrium states like life. While the responsible basic forces are typically investigated spectroscopically, a conductance measurement to probe and control these interactions in a single molecule far out of equilibrium is reported here. Specifically, by separating macroscopic metal electrodes, two π-conjugated, bridge-connected porphyrin decks are peeled off on one side, but compressed on the other side due to the covalent mechanical fixation. We observe that the conductance response shows an exceptional exponential rise by two orders of magnitude in individual breaking events during the stretching. Theoretical studies atomistically explain the measured conductance behavior by a mechanically activated increase in through-bond transport and a simultaneous strengthening of through-space coupling. Our results not only reveal the various interacting intramolecular transport channels in a molecular set of levers, but also the molecules' potential to serve as molecular electro-mechanical sensors and switches.Luminescent metal-organic frameworks (LMOFs) have been extensively studied for their potential applications in lighting, sensing and biomedicine-related areas due to their high porosity, unlimited structure and composition tunability. However, methodical development in systematically tuning the emission properties of fluorescent organic linker-based LMOFs to facilitate the rational design and synthesis of target-specific materials has remained challenging. Herein we attempt to build an emission library by customized synthesis of LMOFs with targeted absorption and emission properties using donor-acceptor-donor type organic linkers. By tuning the acceptor groups (i.e. 2,1,3-benzothiadiazole and its derivatives), donor groups (including modification of original donors and use of donors with different metal-linker connections) and bridging units between acceptor and donor groups, an emission library is developed for LMOFs with their emissions covering the entire visible light range as well as the near-infrared region. This work may offer insight into well controlled design of organic linkers for the synthesis of LMOFs with specified functionality.Metal-organic frameworks (MOFs) are one of the most researched designer materials today, as their high tunability offers scientists a wide space to imagine all kinds of possible structures. Their uniquely flexible customisability spurred the creation of hypothetical datasets and the syntheses of more than 100 000 MOFs officially reported in the Cambridge Structural Database. To scan such large numbers of MOFs, computational high-throughput screenings (HTS) have become the customary method to identify the most promising structure for a given application, and/or to spot useful structure-property relationships. However, despite all these data-mining efforts, only a fraction of HTS studies have identified synthesisable top-performing MOFs that were then further investigated in the lab. In this perspective, we review these specific cases and suggest possible steps to push future HTS more systematically towards synthesisable structures.[This corrects the article DOI 10.1039/D1SC01850G.].[This corrects the article DOI 10.1039/D1SC04265C.].We report a photocatalytic strategy for the chemodivergent radical benzylation of 4-cyanopyridines. The chemistry uses a single photoredox catalyst to generate benzyl radicals upon N-F bond activation of 2-alkyl N-fluorobenzamides. The judicious choice of different photocatalyst quenchers allowed us to select at will between mechanistically divergent processes. The two reaction manifolds, an ipso-substitution path proceeding via radical coupling and a Minisci-type addition, enabled selective access to regioisomeric C4 or C2 benzylated pyridines, respectively. Mechanistic investigations shed light on the origin of the chemoselectivity switch.