Herskindsuarez4863

arker of neurodegeneration in NPC1-disease after onset of clinical symptoms.BACKGROUND Living with a progressive disease as muscular dystrophy (MD) can be challenging for the patient and the entire family from both emotional and practical point of view. We aimed to extend our previously published data about mental health in patients with MDs, also investigating coping profiles of both themselves and their parents. Furthermore, we wanted to verify whether psychological adaptation of patients can be predicted by coping strategies, taking also into account physical impairment, cognitive level and socioeconomic status. METHODS 112 patients with MDs, aged 2-32 were included. Their emotional and behavioural features were assessed through parent- and self-report Achenbach System for Empirically Based Assessment questionnaires and Strength and Difficulties Questionnaires. Development and Well-Being Assessment or Autism Diagnostic Observation Schedule were administered to confirm suspected diagnoses. Coping profile of both parents and patients was assessed through the self-administered New Italian Version of the Coping Orientation to the Problems Experienced questionnaire and its relationship with emotional/behavioural outcome was examined in linear regression analyses. RESULTS High prevalence of intellectual disability and autism spectrum disorders was confirmed in Duchenne MD. Despite the high rate of internalizing symptomatology, we did not report higher rate of psychopathological disorders compared to general population. Parents tend to rely more on positive reinterpretation and less on disengagement coping. Avoidance coping, whether used by parents or patients, and ID, predicted increased emotional/behavioural problems. learn more CONCLUSIONS Psychosocial interventions should address problems of anxiety and depression that people with MDs frequently experience, even through fostering parents' and childrens' engagement coping over disengagement coping.BACKGROUND The prevalence and risk factors of low bone mineral density (BMD) in Asian patients newly diagnosed with inflammatory bowel disease (IBD) have not been fully suggested. AIMS We aimed to examine the prevalence and risk factors of low BMD in young Korean patients newly diagnosed with IBD. METHODS We prospectively enrolled 132 patients aged less than 50 years and newly diagnosed with IBD from six tertiary referral centers in Korea between November 2014 and April 2017. BMD was measured by dual-energy X-ray absorptiometry, and then the Z-score was determined. We defined low BMD as a Z-score ≤ - 1.0. RESULTS Of 68 patients with ulcerative colitis (UC), 22 (32.4%) had low BMD. Also, of 64 patients with Crohn's disease (CD), 24 (37.5%) showed low BMD. Results from multivariate regression analysis identified the risk factors for low BMD as a high level of alkaline phosphatase (ALP) (≥ 140 U/L) (P = 0.010) in UC patients, and being underweight (body mass index ≤ 18.5 kg/m2) (P = 0.017) in CD patients. CONCLUSIONS Our study showed that about one-third of newly diagnosed IBD Asian patients had low BMD. The clinical factors associated with low BMD were a high level of ALP in UC patients, and being underweight, in CD patients. Therefore, measurements of BMD in young patients should be considered at the diagnosis of IBD.The climate change on the impact of grain production potential has significant regional differences. Researchers have studied the grain production potential of various crop combinations or focused on single crop types in a typical area; however, the regional differences of the climate change on the impact of grain production potential were neglected. This paper used the Global Agro-Ecological Zone (GAEZ 3.0) model to focus on the analysis what is the climate change on the impact of grain production potential in different geographic units (Northern Shaanxi Plateau, Guanzhong Basin, Qinba Mountain) in Shaanxi Province of China. The case showed that the precipitation (Pre) what made changes of grain production potential was the most important factor in different geographic units. The increase of Pre had a positive impact on the grain production potential in Northern Shaanxi Plateau and Guanzhong Basin. However, in Qinba Mountain, due to excessive Pre in the Qinba Mountains, the decrease of Pre had a certain positive impact on the grain production potential. The precipitation was less in the Northern Shaanxi Plateau; therefore, its major factors leading to changes of crop production were precipitation and rainfall days. The increase of the mean maximum temperature (Tmx) and the mean minimum temperature (Tmn) had a positive impact of the grain production potential in the Northern Shaanxi Plateau and Guanzhong Basin. The higher temperature had a negative impact on the grain production potential. In Qinba Mountain, the increase of the temperature has a certain negative impact on the grain production potential. It has more influence of Tmx in the Guanzhong Basin and Qinba Mountain rather than that in the Northern Shaanxi Plateau. Generally speaking, the major climatic factors leading grain production potential were Pre and Tmx in Guanzhong Basin and Qinba Mountain.Colony is a key to Microcystis becoming a dominant population and forming blooms. To find the mechanism of colony formation, we investigated cell wall structures of colonial and unicellular strains. Results showed that colonial strains had significant surface layer protein (S-layer) on the surface of cells than unicellular strains by transmission electron microscopy. Western blot showed colonial strains had more S-layer than the unicellular strains. When the S-layer gene (GenBank accession number CAO89090.1) of Microcystis aeruginosa PCC7806 was expressed in Synechocystis sp. PCC6803, PCC6803 aggregated into colonial morphology. The results indicated that the S-layer could promote colony formation in Microcystis. Based on the S-layer sequences of PCC6803 and PCC7806, nine S-layer genes in other Microcystis strains were screened from the GenBank. Sequence comparing showed that the S-layers conserved regions were all located in N-terminal. The S-layers contain repeats-in-toxin (RTX) sequences with Ca2+-binding site, and their amino acid composition, hydrophobicity, isoelectric point, etc.