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Promoting daily moderate-intensity physical activity and activities contributing to an optimistic outlook can protect against poor SRH in old age.The Task Load Index (TLX) is the predominant instrument for self-reporting workload. On the basis of a meta-analytic review of 556 studies, this paper supplies reference values for TLX and its six subscales across domains, technologies, regions, and real-life/lab settings. Across domains, TLX spans mean values from 35 for leisure to 56 for manual labour. TLX tends to be driven upward by the subscales of mental demand and effort and downward by the subscales of physical demand and frustration. For technologies, handheld devices are associated with lower TLX, possibly because they are simpler and more task-specific. TLX also varies across regions in that it is higher for studies in Asia than in Europe and North America. This variation is only partly explained by co-variation in domains. Furthermore, TLX is higher and its subscales more inter-correlated when it is studied in real-life rather than lab settings. Practitioner summary Practitioners can use the reference values supplied in this paper to benchmark their TLX measurements against those from the corpus of TLX research. Furthermore, the reported subscale patterns add to the diagnostic power of the TLX instrument. Abbreviations TLX task load index; MD mental demand; PD physical demand; TD temporal demand; EF effort; PE performance; FR frustration.Mental health symptoms are overrepresented among college students worldwide. The current research investigates the associations among substance use, family functionality, and mental health (depression, anxiety, and stress) among college students in Spain. check details A total of 828 (59.2% female and 40.8% male) college students from two public universities completed a self-reported online survey that included items on demographic information, substance use (alcohol, tobacco, cannabis, cocaine, prescription sedatives, and recreational sedatives), mental health symptoms (using the DASS-21 questionnaire) and family functionality (using the APGAR questionnaire). College students reporting substance use (especially recreational sedatives) and family dysfunctionality were more likely to exhibit symptoms of depression, anxiety and stress. These findings provide support for the underlying role of substance use and family functionality on mental health symptoms. Treatments targeting depression, anxiety, and stress among college students in Spain should aim to reduce substance use by and increase family support of students.The interaction mechanism of guaifenesin drug; (RS)-3-(2-methoxyphenoxy)propane-1,2-diol; and calf thymus DNA was characterized by multiple spectroscopic and molecular docking approaches. The changes in drug electronic absorption with increasing DNA concentration and also the observed significant quenching of guaifenesin emission in the presence of DNA proved the complex formation between guaifenesin and DNA during the interactions. Both the binding constant and thermodynamic parameters for the interaction have been calculated in 283, 298, and 310 K at pH 7.4. The results Δ H 0  = 17.87 kJ/mol and Δ S 0  = 143.31 J/mol.K confirmed the role of hydrophobic force in the guaifenesin-DNA interaction. Circular dichroism study showed that guaifenesin causes decrease in the negative band of CT-DNA and at the same time the positive band increases which indicated the transition of DNA conformation from B to A. KI quenching experiment specifies that guaifenesin binds to DNA via nonintercalative mode. The competitive studies based on known Hoechst 33258 and methylene blue probes proved the groove binding mode in guaifenesin-DNA adduct. Further, full agreement of molecular docking simulation with the experimental results of binding constant and interaction mode, support high accuracy of the results.This paper brings together Reinforcement Sensitivity Theory and other perspectives on wellbeing to test predictions about dimensions of affect which are linked to approach motivation or avoidance motivation. Valence and activation are jointly conceptualised as either approach-affect or avoidance-affect through the diagonal axes of an affective circumplex. Across four studies in three different countries, predictions about Reinforcement Sensitivity Theory's Behavioural Activation System, Behavioural Inhibition System and Fight-Flight-Freeze System are found to be supported. Correlations with external variables are shown to depend on a wellbeing measure's emphasis on approach or avoidance, such that affect and external features which both emphasise motivation to approach or to avoid yield substantially larger intercorrelations than do non-concordant pairs. In addition, joining valence with activation is shown to yield correlational benefits as predicted. Implications of our perspective and operationalisation are reviewed, and specific research recommendations are made.This systematic literary review investigates if an association between Sami dietary habits and cardiometabolic outcomes exists, and examines the dietary characteristics and cardiometabolic status of the Sami population. Included were all articles assessing Sami dietary habits and cardiometabolic disease or risk factors. Embase, Medline and SweMed were searched on 26 September 2019 and articles were screened for eligibility in October 2019. Data were extracted according to Moose Guidelines and the Newcastle Ottawa Scale (NOS) was used to assess risk of bias. The initial search generated 4,195 articles in total. Nine articles met all inclusion criteria. Two were cohort studies and seven were cross-sectional. Rating by NOS ranked from 2/7 to 8/9 stars. The studies were largely descriptive and only few had results regarding a direct association between Sami dietary habits and cardiometabolic outcomes. The findings demonstrated no association between consumption of certain Sami food items and blood-lipids or mortality from CVD/CHD. A higher intake of fat, protein, reindeer-meat and coffee and a slightly lower blood pressure and mortality from CVD/CHD was seen among Sami compared with non-Sami. The limited amount and descriptive nature of the eligible articles indicate that resaerch within the fielt is limited. Thus, additional longitudinal studies are suggested.