Heinballard6810

Introduction Classification are essential part of scientific methodology and has important role in medical reporting system. Even after having 46 years long history, Seasonal Hyperacute Panuveitis (SHAPU), the blinding diseases reported mainly from Nepal lacks a standard classification system. Thus, we aim to contribute in the ophthalmic nosology by purposing a classification system for SHAPU.Methodology The classification is suggested on the background of prolonged experience of this entity by the group of investigators who have dedicated years of research on this topic.Conclusion We are optimistic that the proposed classification system will help in effective planning and evaluation of this ocular emergency condition and deliver the appropriate and reliable information for timely management and prevention of complications.

A portion of patients with chronic myeloid leukaemia (CML) develop resistance to the Bcr-Abl tyrosine kinase inhibitors (TKIs), limiting the clinical applications. Previous results have demonstrated the synergistic effects between cryptotanshinone (CPT) and imatinib on apoptosis of CML cells

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To determine the antileukemia effects of CPT and TKIs on the resistant CML cells, and further investigate the effect of combined treatment of CPT and imatinib on tumour growth and apoptosis in the xenograft model and clarify its regulatory mechanisms.

The combination effects of CPT and second-generation TKIs were evaluated in resistant CML cells K562-R. CPT and imatinib were orally administered once daily for 21 days on K562-R xenografts in nude mice (6 per group). Tumour proliferation and apoptosis were examined by Ki-67, PCNA and TUNEL staining. The expression levels of apoptotic markers and activities of STAT3 and eIF4E pathways were determined via immunohistochemistry staining and western blotting analysis.

CPT significantly enhanced the antiproliferative effects of TKIs, via triggering cleavages of caspase proteins, and inhibiting activities of STAT3 and eIF4E pathways. The administration of CPT and imatinib dramatically inhibited the tumour growth of xenografts and achieved a suppression of 60.2%, which is 2.6-fold higher than that of single imatinib group. Furthermore, CPT and imatinib increased the apoptotic rates and markedly decreased the phosphorylation levels of STAT3 and eIF4E.

Our results demonstrated that CPT could significantly enhance the antileukemia efficacy of TKIs, suggesting the therapeutic potential of CPT to overcome CML resistance.

Our results demonstrated that CPT could significantly enhance the antileukemia efficacy of TKIs, suggesting the therapeutic potential of CPT to overcome CML resistance.Summary The main purpose of the current study was to assess whether there are significant differences among variables, such as social workers' familiarity with the crisis intervention model, receiving up-to-date information about the latest developments in COVID-19, having adequate information about what the symptoms of COVID-19 are, and willingness to work with COVID-19 patients, and social workers' ability to apply the crisis intervention model when they are working with clients and its three sub-scales (assessing and identifying the problem, establishing a relationship, and formulating an action plan). The cross-sectional survey method was used to conduct the sample of the study. The sample (N = 274) used in the study consisted of social workers in Kuwait.Findings The results showed that CIS is valid and reliable and can be trusted to measure levels according to the purpose of the study. Analysis using T-test showed significant relationships between the CIS and study's variables at p less then .05.Application This study would help to raise the knowledge and awareness about the ability of social workers to apply the crisis intervention model during COVID-19 pandemic when they are working with clients and what variables may be associated with it.Introduction Thyroid-associated orbitopathy (TAO) is one of the most common autoimmune inflammatory disorders of the orbit. The presence of anti-thyroid antibodies is believed to play a role in the pathogenesis and clinical status of the TAO patients. Herein, we review the usefulness of TPOAb as a biomarker for TAO.Methods A systematic search in MEDLINE library was conducted. Results Twenty studies were included. TPO is expressed in orbital tissues, and the polymorphism rs11675434 SNP has proven to be associated with clinically evident TAO. Studies in pediatric patients have shown a positive correlation between high TPOAb levels and TAO. In contrast, results in adults are inconsistent. Some studies imply a protective role of TPOAb, yet the majority did not find any association. Some authors have suggested an implication of TPOAb in the pathophysiology of TAO in TRAb-negative patients.Conclusions The role of TPOAb in TAO remains unclear and controversial.Sarcoidosis is a chronic inflammatory disease of unknown etiology that affects many systemic organs, including the eye. The eye is the second most frequently affected organ in patients with sarcoidosis after lung disease. Approximately 30-50% of patients with systemic sarcoidosis develop uveitis, which is a sight-threatening intraocular inflammatory disorder. Sarcoidosis is the leading cause of uveitis in Japan and is one of the major clinical entities in many countries. Therefore, uveitis in association with sarcoidosis (ocular sarcoidosis) is considered essential in clinical practice in ophthalmology. The current review focuses on distinguishing features of ocular sarcoidosis, diagnosis, management, and discussion of the etiology of ocular sarcoidosis.

Point-of-care ultrasonography is an invaluable asset for inpatient decision-making. Whether handheld ultrasound can be utilized in the outpatient management of pulmonary hypertension (PH) is unknown.

We investigated whether a handheld ultrasound estimate of right atrial pressure correlates with B-type natriuretic peptide (BNP) and clinical outcome over time in PH outpatients.

This prospective study included outpatients in a PH Comprehensive Care Center clinic who had a same-day BNP level. learn more We used a handheld ultrasound to measure inferior vena cava (IVC) size and collapsibility, which were used to estimate right atrial pressure (eRAP) and categorize it as normal, intermediate, or high. Correlation analysis was used to compare these ultrasound measurements to BNP at baseline and over time. Cox regression was used to determine if these measurements were associated with time to clinical worsening.

Ninety patients (60% Group 1 PH) were enrolled. Patients with an intermediate or high eRAP category at baseline had higher BNP levels than patients with normal eRAP.