Haydenbrandstrup2235

COVID 19 pandemic lockdown affects normal daily activities making people vulnerable to sleep disorders, including insomnia and Internet addiction. The present study explores the prevalence of insomnia and Internet addiction amidst the pandemic while staying at home.

Data have been collected from 585 individuals of both sexes online through social media using a structured questionnaire that consists of insomnia severity and Internet addiction. Chi square and logistic regression analysis were done to associate the insomnia severity with Internet use behavior and addiction.

The overall prevalence of insomnia and subthreshold (mild) insomnia are 12.13% and 31.97%, respectively, with females had insomnia more than males. Internet addiction correlates with insomnia as staying online more than initially intended increases insomnia significantly.

COVID 19 pandemic lockdown affects sleep health as sleep-related disorders are on the rise, which could correlate to mental health. The study further seeks attention from researchers, health experts, and related stakeholders to develop a more holistic approach to uncover the problems and promote sleeping awareness.

COVID 19 pandemic lockdown affects sleep health as sleep-related disorders are on the rise, which could correlate to mental health. The study further seeks attention from researchers, health experts, and related stakeholders to develop a more holistic approach to uncover the problems and promote sleeping awareness.This paper explores how cultural understandings of the autonomy and responsibility of science in modern society are manifested in two contemporary science novels about research misconduct in biomedical research. In doing so, it looks at several facets of the societal impact of and on public and private biomedical research, especially with respect to changing authority relations and their epistemic and institutional consequences. The analysis focuses on the multi-layered ways in which social and epistemic interests are treated in Allegra Goodman's Intuition and Jennifer Rohn's The Honest Look. Goodman's novel demonstrates how, intensified by the economization of science, internal cultural and institutional aspects of the scientific field enable social configurations that, among others, encourage scientific malpractice and lead to the delay of research projects epistemically and socially worth pursuing. In contrast, Rohn's novel exemplifies the corrosion of the ideal scientific ethos by profit-driven practices in private-sector biomedical sciences. The concluding discussion juxtaposes these findings with pertinent contemporary phenomena in modern science systems to provide a more substantial understanding of the interpenetration between science and other social spheres.Communities, professionals, and researchers recognize that environmental factors contribute to the health inequities experienced by vulnerable populations in the U.S. These environmental health injustices persist despite well-developed systems for both public health and environmental protection. The root cause of these issues is often "siloed" decision-making by separate health and environmental institutions. Health Impact Assessment (HIA) can be an important tool for bridging these silos to promote health equity at the local level. SB203580 in vitro This raises the question how can external resources best support local initiatives? This paper examines the interaction between national, state, and non-governmental efforts to promote HIA and local actions to promote healthy and equitable built environment in Duluth, MN. A wide range of local activities in Duluth aimed to alter the long term trends, decision processes, and institutions shaping its built environment. These included integrating health in brownfield redevelopment, local land use plans, food access, and transportation decisions. Technical and financial support from external groups played a key role in developing the community's capacity to promote health equity across public, private, and non-profit organizations. link2 These multiple streams of action culminated in the mayor's declaration in 2016 that health and fairness would be adopted as key goals of the city's new Comprehensive Plan. link3 How did such innovative efforts thrive in a small, post-industrial city with limited resources? Duluth's experiences provide insight into how external governmental, funding, academic, and non-profit entities can more effectively, efficiently, and equitably support the evolution of local initiatives.

Prophylactic anticoagulation with rivaroxaban significantly reduced the risk of cancer-associated thrombosis during the intervention period in the CASSINI trial. Direct oral anticoagulants may increase the risk of gastrointestinal (GI) tract bleeding in patients with an in situ GI tract cancer or lesion.

This post hoc analysis characterized the efficacy and safety of rivaroxaban in patients with and without gastric/gastroesophageal junction (G/GEJ) tumors.

Primary and secondary efficacy end points and adjudicated bleeding events, including bleeding sites, were analyzed for the intent-to-treat population by cancer type (G/GEJ vs non-G/GEJ) for the 180-day observation period.

In patients with G/GEJ tumors, the rates for the primary efficacy end point were 3.4% for rivaroxaban versus 6.9% for placebo (hazard ratio [HR], 0.45; 95% confidence interval [CI], 0.11-1.80). In patients with non-G/GEJ tumors, the rivaroxaban group had a lower risk of the primary end point (6.6% vs 9.3%; HR, 0.70; 95% CI, 0.40-1.21). Rates of major bleeding in patients with G/GEJ tumors were 4.6% (4/88) versus 1.2% (1/85) for rivaroxaban and placebo; rates in patients with non-G/GEJ tumors were 1.3% (4/317) versus 0.9% (3/319), respectively.

Excluding patients with G/GEJ tumors resulted in a definable population of cancer patients who achieved an improved benefit-risk balance from rivaroxaban prophylaxis.

Excluding patients with G/GEJ tumors resulted in a definable population of cancer patients who achieved an improved benefit-risk balance from rivaroxaban prophylaxis.We present a comparative analysis of inertial-based odometry algorithms for the purpose of assisted return. An assisted return system facilitates backtracking of a path previously taken, and can be particularly useful for blind pedestrians. We present a new algorithm for path matching, and test it in simulated assisted return tasks with data from WeAllWalk, the only existing data set with inertial data recorded from blind walkers. We consider two odometry systems, one based on deep learning (RoNIN), and the second based on robust turn detection and step counting. Our results show that the best path matching results are obtained using the turns/steps odometry system.We integrated microscopy, spectroscopy, culturing and molecular biology, and aqueous chemistry techniques to evaluate arsenic (As) accumulation in hydroponically grown Schizachyrium scoparium inoculated with endophytic fungi. Schizachyrium scoparium grows in historically contaminated sediment in the Cheyenne River Watershed and was used for laboratory experiments with As(V) ranging from 0 to 2.5 mg L-1 at circumneutral pH. Arsenic accumulation in regional plants has been a community concern for several decades, yet mechanisms affecting As accumulation in plants associated with endophytic fungi remain poorly understood. Colonization of roots by endophytic fungi supported better external and vascular cellular structure, increased biomass production, increased root lengths and increased P uptake, compared to noninoculated plants (p value less then 0.05). After exposure to As(V), an 80% decrease of As was detected in solution and accumulated mainly in the roots (0.82-13.44 mg kg-1) of noninoculated plants. Endophytic fungi mediated intracellular uptake into root cells and translocation of As. Electron microprobe X-ray mapping analyses detected Ca-P and Mg-P minerals with As on the root surface of exposed plants, suggesting that these minerals could lead to As adsorption on the root surface through surface complexation or coprecipitation. Our findings provide new insights regarding biological and physical-chemical processes affecting As accumulation in plants for risk assessment applications and bioremediation strategies.

Thyrotoxic periodic paralysis (TPP) characterized by acute weakness, hypokalemia, and hyperthyroidism is a medical emergency with a great challenge in early diagnosis since most TPP patients do not have overt symptoms.

This work aims to assess artificial intelligence (AI)-assisted electrocardiography (ECG) combined with routine laboratory data in the early diagnosis of TPP.

A deep learning model (DLM) based on ECG12Net, an 82-layer convolutional neural network, was constructed to detect hypokalemia and hyperthyroidism. The development cohort consisted of 39 ECGs from patients with TPP and 502 ECGs of hypokalemic controls; the validation cohort consisted of 11 ECGs of TPP patients and 36 ECGs of non-TPP individuals with weakness. The AI-ECG-based TPP diagnostic process was then consecutively evaluated in 22 male patients with TTP-like features.

In the validation cohort, the DLM-based ECG system detected all cases of hypokalemia in TPP patients with a mean absolute error of 0.26 mEq/L and diagnosed TPP with an area under curve (AUC) of approximately 80%, surpassing the best standard ECG parameter (AUC = 0.7285 for the QR interval). Combining the AI predictions with the estimated glomerular filtration rate and serum chloride boosted the diagnostic accuracy of the algorithm to AUC 0.986. In the prospective study, the integrated AI and routine laboratory diagnostic system had a PPV of 100% and

-measure of 87.5%.

An AI-ECG system reliably identifies hypokalemia in patients with paralysis, and integration with routine blood chemistries provides valuable decision support for the early diagnosis of TPP.

An AI-ECG system reliably identifies hypokalemia in patients with paralysis, and integration with routine blood chemistries provides valuable decision support for the early diagnosis of TPP.

Androgen deprivation therapy (ADT) reduces muscle and bone mass, increasing frailty in men with prostate cancer. The liver mediates the whole body anabolic effects of testosterone. Based on first-pass metabolism, liver-targeted testosterone treatment (LTTT) entails oral delivery of a small dose of testosterone that does not raise peripheral blood testosterone levels. LTTT reduces blood urea and stimulates protein anabolism in hypogonadal men and postmenopausal women. We investigated whether LTTT prevents loss of lean and bone mass during ADT.

A 6-month, double-blind, placebo-controlled study of testosterone 40 mg/day in 50 men. Primary outcome measures were lean mass and bone mineral content (BMC). Testosterone, urea and prostate-specific antigen (PSA) were monitored. Patients were withdrawn if PSA exceeded 4 ng/mL.

42 patients completed the study. Mean (95% CI) testosterone rose during LTTT but not placebo treatment [∆ 2.2 (1.3-3.0)

-0.7 (-1.5 to 0.2) nmol/L;

 < 0.01]. Mean PSA level did not change significantly during either treatment. Blood urea fell [∆ -0.4 (-0.9 to -0.1) mmol/L] during LTTT but not placebo [∆ 0.05 (-0.8 to 0.9) mmol/L]. BMC [∆ 49 (5 to 93) g;

 < 0.02] and lean mass [∆ 0.8 (-0.1 to 1.7) kg;

 = 0.04) increased compared to placebo. Five patients on LTTT withdrew from increased PSA levels, all returning to baseline levels.

LTTT shows promise as a simple therapy for preventing sarcopenia and bone loss during ADT. LTTT may induce reversible PSA rise in some patients. Further studies are required to optimize LTTT dose in ADT. LTTT has potential application in other catabolic states in men and women.

LTTT shows promise as a simple therapy for preventing sarcopenia and bone loss during ADT. LTTT may induce reversible PSA rise in some patients. Further studies are required to optimize LTTT dose in ADT. LTTT has potential application in other catabolic states in men and women.