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After adjustment, AF was associated with increased incidences of TIA/stroke (OR 1.36, 95% CI 1.01, 1.85), acute kidney injury (OR 1.54, 95% CI 1.33, 1.78), blood transfusion (OR 1.14, 95% CI 1.00, 1.30), transfer to a skilled nursing facility (OR 1.38, 95% CI 1.23, 1.55), and longer average LOS (CIE 1.30, 95% CI 1.06, 1.54). AF was not associated with inpatient mortality (OR 1.09, 95% CI 0.81, 1.48). Conclusions AF is prevalent among patients undergoing TAVR, and is associated with higher incidences of inpatient complications, discharge to a skilled nursing facility, and longer average LOS. While the incidence of many complications has declined in the past few years, continued efforts to further reduce complications in patients with AF is urgently required for expansion of TAVR to broader populations. 2020 Cardiovascular Diagnosis and Therapy. All rights reserved.Layered materials, such as MoS2, are being intensely studied due to their interesting properties and wide variety of potential applications. These materials are also interesting as supports for low-dimensional metals for catalysis, while recent work has shown increased interest in using 2D materials in the electronics industry as a Cu diffusion barrier in semiconductor device interconnects. The interaction between different metal structures and MoS2 monolayers is therefore of significant importance and first-principles simulations can probe aspects of this interaction not easily accessible to experiment. Previous theoretical studies have focused particularly on the adsorption of a range of metallic elements, including first-row transition metals, as well as Ag and Au. However, most studies have examined single-atom adsorption or adsorbed nanoparticles of noble metals. This means there is a knowledge gap in terms of thin film nucleation on 2D materials. To begin addressing this issue, we present in this paper ein-Institut.In the present study Ar+ cluster ions accelerated by voltages in the range of 5-10 kV are used to irradiate single crystal ZnO substrates and nanorods to fabricate self-assembled surface nanoripple arrays. The ripple formation is observed when the incidence angle of the cluster beam is in the range of 30-70°. The influence of incidence angle, accelerating voltage, and fluence on the ripple formation is studied. Wavelength and height of the nanoripples increase with increasing accelerating voltage and fluence for both targets. The nanoripples formed on the flat substrates remind of aeolian sand ripples. The ripples formed at high ion fluences on the nanorod facets resemble well-ordered parallel steps or ribs. The more ordered ripple formation on nanorods can be associated with the confinement of the nanorod facets in comparison with the quasi-infinite surface of the flat substrates. K975 Copyright © 2020, Zeng et al.; licensee Beilstein-Institut.There is an increasing interest in the use of plant viruses as vehicles for anti-cancer therapy. In particular, the plant virus brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) are novel potential nanocarriers for different therapies in nanomedicine. In this work, BMV and CCMV were loaded with a fluorophore and assayed on breast tumor cells. The viruses BMV and CCMV were internalized into breast tumor cells. Both viruses, BMV and CCMV, did not show cytotoxic effects on tumor cells in vitro. However, only BMV did not activate macrophages in vitro. This suggests that BMV is less immunogenic and may be a potential carrier for therapy delivery in tumor cells. Furthermore, BMV virus-like particles (VLPs) were efficiently loaded with small interfering RNA (siRNA) without packaging signal. The gene silencing was demonstrated by VLPs loaded with siGFP and tested on breast tumor cells that constitutively express the green fluorescent protein (GPF). After VLP-siGFP treatment, GFP expression was efficiently inhibited corroborating the cargo release inside tumor cells and the gene silencing. In addition, BMV VLP carring siAkt1 inhibited the tumor growth in mice. These results show the attractive potential of plant virus VLPs to deliver molecular therapy to tumor cells with low immunogenic response. Copyright © 2020, Nuñez-Rivera et al.; licensee Beilstein-Institut.[This corrects the article DOI 10.3762/bjnano.10.173.]. Copyright © 2020, Hata et al.; licensee Beilstein-Institut.The overall goal in the treatment of type 2 diabetes mellitus (T2DM) is remission. However, the effects of a sodium-glucose cotransporter 2 inhibitor (SGLT2i) on remission of T2DM are unknown. We herein report a case involving an overweight 43-year-old man who completely recovered from T2DM after SGLT2i therapy (dapagliflozin at 5 mg/day). In the pretreatment period, he had a body mass index (BMI) of 26.0 kg/m2, hemoglobin A1c (HbA1c) concentration of 10.3%, advanced insulin resistance, pancreatic β-cell dysfunction, and fatty liver. Eighteen months after comprehensive therapy, including the administration of an SGLT2i and metformin, his BMI had decreased to 21.3 kg/m2 and his glycemic control was almost normal (HbA1c of 5.3%) despite discontinuation of all hypoglycemic medications. This report is the first to propose the usefulness of the combination therapy of SGLT2i and metformin for achieving normal body weight and remission of newly diagnosed T2DM in a real-world clinical situation. Copyright © 2020, Sugiyama et al.INTRODUCTION Films continue to be a popular form of entertainment amongst children and adolescents. The objective of this study was to determine the most common themes depicted in a select number of rated-R films released 2012-2017. METHODS A total of 25 films were independently viewed and analyzed by five reviewers. RESULTS The most common positive themes were "encouragement", "helping others", "teamwork", "compassion", and "honesty" (2.3, 1.7, 1.7, 1.6, 1.4 mean events per hour, respectively). The most common negative themes were "use of inappropriate language", "use of a lethal weapon", "physical fighting", "dishonesty", and "demonstrating excessive anger" (8.9, 4.4, 3.4, 2.3, 2.2 mean events per hour, respectively). CONCLUSION The most common positive themes in our sample were associated with service, collaboration, and honesty/humility, and the most common negative themes were associated with violence. We encourage co-viewing and active mediation, focusing on the themes found in films, as a method to guide children through their development process.