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Children of mothers with significant depressive symptoms had severe behavioral problems at ages 4, 5, 6, 7, and 9 years. Moreover, compared with children whose mothers were not depressed, those whose mothers had mild or moderate symptoms had impaired executive function at ages 7, 8, and 9 years.

Maternal depression up to 2 years after childbirth affects childhood behavior and executive function into middle childhood.

Maternal depression up to 2 years after childbirth affects childhood behavior and executive function into middle childhood.

Very late sleep rhythms are risks for social adjustment problems in adolescence. Using ecological momentary assessment data, we quantified and visualized temporal and contemporaneous within-persons dynamical relations of sleepiness and emotions in adolescents with and without late sleep rhythms.

We analyzed a temporal network via multilevel vector autoregression (mlVAR) modeling and a contemporaneous network through the partial associations between the residuals of temporal and the between-subject multilevel models. We tested whether these networks were different between those with a late circadian rhythm [concurrent delayed sleep phase (DSP) N=172, 37% boys, 63% girls] and those without (N=143, 22% boys, 78% girls).

In adolescents without DSP, the temporal networks showed continuity only for low mood from the previous to the following time point. In adolescents with DSP, there were more predictable patterns of emotions. Feelings of depression led to a decrease of positive emotions and increase of irritation and anxiety. INCB39110 The contemporaneous networks showed clusters of positive and negative emotions in both groups and sleepiness decreased the experience of positive emotions concurrently.

DSP in our current study was based only on one out of three diagnostic criteria of the full disorder (DSM-5) and it was assessed only once.

These findings indicate that the dynamic organization of emotions and sleepiness is different in adolescents with and without DSP. DSP adolescents have more predictable and maladaptive emotional patterns during the day. Results provide new insight about why individuals with DSP are at a heightened risk for decreased emotional adjustment.

These findings indicate that the dynamic organization of emotions and sleepiness is different in adolescents with and without DSP. DSP adolescents have more predictable and maladaptive emotional patterns during the day. Results provide new insight about why individuals with DSP are at a heightened risk for decreased emotional adjustment.

Oral literacy is an important aspect of physician and patient/family communication. Adequate communication is essential in the shared decision-making process and is inherently important in pediatric surgical consultations where parents must make decisions for their children. The aim of this study was to describe oral literacy in pediatric otolaryngology consultations and how it may relate to shared decision-making in a cohort of parents experiencing significant decisional conflict.

Thirty-six parent/patient-physician interactions from two pediatric otolaryngology clinics were recorded. Parents completed the Decision Conflict Scale (DCS), and both parents and physicians completed the Shared Decision-making (SDM-Q-9/SDM-Q-Doc) questionnaires. Language complexity was assessed by the Flesch Reading Ease Scale (FRES), the Simple Measure of Gobbledygook (SMOG) Readability Formula, and a series of grammar statistics. link2 The Pearson product-moment was used to examine the correlation between measures.

The mean age arents who use a more complex vocabulary may experience less conflict.

Physicians demonstrated higher language complexity than that of parents in this study. Differences in language complexity between physicians and parents do not appear to play a substantial role in decisional conflict or the perception of shared decision-making in general. However, parents who use a more complex vocabulary may experience less conflict.Pontederia cordata can tolerate heavy metal toxicity and possesses great potential for phytoremediation of heavy-metal-contaminated wetlands, yet how it copes with heavy metal stress has still not been determined. Hydroponic experiments were used to assess the effects of various levels of Cd2+ on the photosynthesis and activity of redox-regulatory systems in the plant leaves, and we also sought to elucidate the tolerance mechanism of the plant to Cd2+ by investigating Cd2+ enrichment characteristics and chemical forms. The plant can manage a low cadmium concentration (≤0.04 mM) with relatively stable biomass and photosynthetic performance. Cd2+ at the highest concentration (0.44 mM) decreased superoxide dismutase and peroxidase activities by 37.17% and 93.29%, respectively. Similar trends were demonstrated in the contents of ascorbic acid, carotenoids, lutein, glutathione, and non-protein thiol, as well as phytochelation in the leaves, exacerbating membrane peroxidation despite the significantly increased catalase activity observed. Moreover, the highest Cd2+ concentration disturbed the biosynthesis of chlorophyll precursors in the leaves, reduced chlorophyll a and b, as well as total chlorophyll contents by 60.47%, 67.47%, and 68.12%, respectively, which inhibited photosynthesis, leading to a decline in biomass. Compared with maximum quantum efficiency (Fv/Fm) and the potential activity (Fv/Fo) of photosystem II, the performance index for energy conservation from photons absorbed by PSII to the reduction of intersystem electron acceptors (PIabs), and of PSI end acceptors (PItotal), can indicate Cd2+ toxicity to the photosynthetic apparatus in the leaves. 49.95%-76.90% of the Cd2+ was sequestered in the plant roots, restraining translocation from roots to shoots, which is considered a tolerance mechanism, probably resulting from disturbed transpiration in leaves and increased Cd2+ content with low activity. Pontederia cordata is a candidate plant for phytoremediation of heavy-metal -contaminated wetlands.

Many vulvar dermatoses (VDs) are chronic and cannot be "cured," thus affected women must learn to live with the impact of the disease, and its treatment, on their quality of life.

To qualitatively investigate the impact of VDs on women's quality of life through firsthand accounts.

12 women, 7 with lichen sclerosus and 5 with erosive vulvovaginal lichen planus recruited from a vulvar disease clinic participated in in-depth, exploratory interviews. Scripts were analyzed by applying a thematic network. link3 The following steps were used (1) coding the text, (2) development of descriptive themes, and (3)generation of thematic networks.

The main outcome explored was the narrative experiences of women living with VDs.

A global theme of suffering emerged. Themes associated with this suffering were organized under the themes of isolation, interference, and grieving. Women felt isolated because they felt unable to talk about their suffering; experienced a lack of external validation and support; and felt differennot represent the experience of women living with VDs who do not wish to discuss their VDs or who are undiagnosed, untreated, and/or treated by other health-care providers.

Women described profound impact of VDs on psychological and sexual health. Sadownik LA, Koert E, Maher C, etal. A Qualitative Exploration of Women's Experiences of Living With Chronic Vulvar Dermatoses. J Sex Med 2020;171740-1750.

Women described profound impact of VDs on psychological and sexual health. Sadownik LA, Koert E, Maher C, et al. A Qualitative Exploration of Women's Experiences of Living With Chronic Vulvar Dermatoses. J Sex Med 2020;171740-1750.

Clinical assessment and management of sexual difficulties after gynecological cancer remain a neglected aspect of women's rehabilitation.

To develop and validate a patient-reported outcome measure of sexual well-being for women experiencing sexual consequences of cervical and endometrial cancer treatment for use in routine follow-up.

This is a sequential mixed method study comprising (i) in-depth qualitative interviews (n=21 of 118) to generate items regarding sexual consequences of cervical or endometrial cancer and treatment; (ii) questionnaire construction with 51 core items (all respondents) and 4 subsections (18-58 items), depending on the relationship status and whether or not participants were sexually active (SA/NSA); (iii) item refinement following cognitive debriefing (n=13 of 21); (iv) validation of resultant items via postal survey (n=788 women) and Rasch analysis; and (v) creation of brief (14-item) clinical screener. Women attending routine follow-up (3 months to 5 years) at 6 English cancxual Morbidity Assessment in Gyne-Oncology Follow-Up Development of the Sexual Well-Being After Cervical or Endometrial Cancer (SWELL-CE) Patient-Reported Outcome Measure. J Sex Med 2020;172005-2015.

Sexual Well-being after Cervical or Endometrial Cancer is a novel and psychometrically valid sexual well-being measure for clinical assessment of female sexual difficulties after cervical or endometrial cancer treatment. White ID, Tennant A, Taylor C, Sexual Morbidity Assessment in Gyne-Oncology Follow-Up Development of the Sexual Well-Being After Cervical or Endometrial Cancer (SWELL-CE) Patient-Reported Outcome Measure. J Sex Med 2020;172005-2015.

Stress urinary incontinence (SUI) is a common, distressing health issue which affects many women. Mid-urethral sling (MUS) surgeries are recommended as gold standard interventions, although evidence regarding their impact on female sexual function remains controversial.

To provide high-quality evidence of the impact of MUS surgeries on sexual functions in women with SUI.

A systematic search of PubMed, Embase, and the Cochrane Library was conducted to identify studies assessing the effect of MUS treatments on sexual functions in women with SUI. The included studies were prospective randomized or non-randomized trials which assessed patients using 2 validated questionnaires, the Female Sexual Function Index (FSFI) and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12). Pre- and postoperative data regarding sexual function were extracted. Meta-analysis of comparable data was performed using Review Manager (version 5.3) software.

The relationship between MUS interventions and sen with SUI. Lai S, Diao T, Zhang W, et al. Sexual Functions in Women With Stress Urinary Incontinence After Mid-Urethral Sling Surgery A Systematic Review and Meta-Analysis of Prospective Randomized and Non-Randomized Studies. J Sex Med 2020;171956-1970.

More than one-third of patients with acute myeloid leukemia (AML) will relapse after allogenic hematopoietic cell transplant (allo-HCT). The main challenge is to overcome disease resistance to achieve a new complete remission while avoiding excessive toxicity. Gemtuzumab ozogamicin (GO), a conjugate of calicheamicin linked to the humanized monoclonal anti-CD33 antibody, has been used for refractory or relapsed AML with promising response rates, but liver toxicity of GO has long been considered a limiting factor.

We included 18 consecutive patients with AML relapsing after a first allo-HCT and treated with fractioned GO (fGO) and intensive chemotherapy. The median age was 40 years (range, 18-65).

The overall response rate was 72% (13/18), including 7 complete remissions. No death was attributed to treatment toxicity. The main liver toxicity was transient and consisted of transaminase level elevation and hyperbilirubinemia. No cases of veno-occlusive disease were observed after the GO treatment. From the time of salvage treatment initiation, 1- and 2-year OS rates were 54% (95% confidence interval, 28%-74%) and 42% (95% confidence interval, 19%-63%), respectively.