Harrisonyates3375

Combination therapy using palbociclib with Bay11-7082 was significantly more effective in hepatoblastoma and HCC treatment than single administration. Moreover, blockade of IKK-NF-κB or AKT pathway enhanced effects of palbociclib on RB1-intact K-Ras mutated lung and colon cancers. In conclusion, CDK4/6 inhibitors have a potential to treat a wide variety of RB1-intact cancers including HCC when combined with an appropriate kinase inhibitor.The aim of the present study was to design a delivery system of curcumin (CU) loaded solid lipid nanoparticles (CU-CSLNs) for evaluating the antimicrobial properties in hamburger patty. Solid lipid nanoparticle (SLN) was prepared through a homogenizing technique. A response surface methodology was applied to optimize the CU-CSLNs to minimize the particle size (PS), polydispersity index (PDI), as well as to maximize the zeta potential to avoid aggregation of particles. The optimized sample revealed a spherical morphology under scanning electron microscope (SEM) and dynamic light scattering (DLS) with particle sizes of 126.87 ± 0.94 nm and 0.21 ± 0.025 PDI. The zeta potential and encapsulation efficiency (EE %) were found to be -30 ± 0.3 mV and 99.96 ± 0.01%, respectively. The CSLNs exhibited higher in vitro antimicrobial effect (142 µg·ml-1 ) against Staphylococcus aureus and generic Escherichia coli as compared to free CU (1000 µg·ml-1 ). Finally, the CSLNs antimicrobial effect was tested in hamburger patty inoculated with foodborne pathogens during eight days of storage at 4 °C. The results indicated that CSLNs had a higher antimicrobial effect than free CU. GSK2982772 This study provides insight into the preparation of the novel antimicrobial nanoparticles for food safety applications.

Hypertension is an important cardiovascular risk factor that is prevalent in the systemic lupus erythematosus patient population. Here, we have investigated whether intestinal microbiota is involved in hypertension in a genetic mouse model of systemic lupus erythematosus.

Twenty-six-week-old female NZW/LacJ (control) and NZBWF1 (F1 hybrid of New Zealand Black and New Zealand White strains; systemic lupus erythematosus) mice were treated for 6 weeks with a broad-spectrum antibiotic mixture or with vancomycin. Faecal microbiota transplantation was performed from donor systemic lupus erythematosus group to recipient to germ-depleted or germ-free mice.

Antibiotic treatment inhibited the development of hypertension and renal injury, improved endothelial dysfunction and vascular oxidative stress, and decreased aortic Th17 infiltration in NZBWF1 mice. High BP and vascular complications found in systemic lupus erythematosus mice, but not autoimmunity, kidney inflammation and endotoxemia, were reproduced by the rythematosus microbiota were mediated by Th17 infiltration in the vasculature.

This study aimed to determine the history of childhood trauma and the relationship between childhood trauma and the course of the disease in female patients with bipolar disorder.

This study was conducted on 80 female patients in an acute women's psychiatric clinic in a psychiatric hospital in Turkey between April and July 2016.

Emotional abuse had a statistically negative effect on the onset of bipolar disorder (F = 7.830; p < 0.01). In addition, physical neglect had a statistically positive effect on the duration of treatment (F = 6.811; p < 0.05).

Psychiatric nurses must systematically assess childhood trauma and plan psychotherapeutic interventions accordingly.

Psychiatric nurses must systematically assess childhood trauma and plan psychotherapeutic interventions accordingly.

Posttraumatic growth (PTG) can occur after experiencing traumatic events. Our purpose was to examine factors associated with PTG experiences of healthcare workers within an academic-medical center.

A correlational study was conducted using a convenience sample of 479 healthcare workers at a large academic-medical center.

Having children living at home, serving the pediatric population, longer duration of alcohol abstinence, and having received treatment for trauma were significantly associated with greater PTG scores. Compared to nondirect care staff, advance practice providers, nursing staff, social work/psychologists, and pharmacy staff had significantly lower PTG scores.

Understanding the positive psychological changes that occur in workers after trauma experiences may provide insight to guide interventions that promote healthcare worker wellbeing.

Understanding the positive psychological changes that occur in workers after trauma experiences may provide insight to guide interventions that promote healthcare worker wellbeing.

This study explores the effects of an emotion-focused training program (EFTP) and an interactive activity (placebo) on nursing students' skills in recognizing and expressing emotions.

The research was conducted as a randomized, placebo and control group, and experimental study with repeated measurements. One hundred and twenty nursing students were randomly assigned to the groups. The EFTP was carried out for 10 sessions in the study group.

The emotional awareness and emotion expression scores of the students in the training group were significantly higher than those of the students in the placebo and control groups (p < 0.05).

The EFTP can be used in the nursing undergraduate curriculum to promote emotional awareness and improve skills of emotional expression.

The EFTP can be used in the nursing undergraduate curriculum to promote emotional awareness and improve skills of emotional expression.Peiyuan Tongnao capsule (PTC) plays an important role in clinical application due to its excellent curative efficacy in the treatment of ischemic stroke and chronic cerebral circulation insufficiency. To standardize and rationalize the clinical application of PTC, a rapid and sensitive method based on ultra-high performance liquid chromatography/quadrupole-Orbitrap mass spectrometry with parallel reaction monitoring (PRM) mode was developed and validated for the pharmacokinetic (PK) study. Ten bioactive compounds (aucubin, salidroside, echinacoside, paeoniflorin, verbascoside, liquiritin, 2,3,5,4'-tetrahydroxy stilbene-2-O-β-d-glucoside, coumarin, glycyrrhizic acid, and emodin) were simultaneously determined in rat plasma. All calibration curves exhibited good linearity (r2  > 0.99). The lower limits of quantification were 0.082-13.291 ng mL-1 . The intra- and inter-day precision was 0.54-12.36%, whereas the intra- and inter-day accuracy ranged from 100.45 to 114.00%. The mean extraction recoveries were 81.77-117.