Haleythiesen6920

VAS scores. MCID achievement varied for PROMIS PF and VAS back, suggesting that though BMI may affect postoperative outcome values, obesity may impact a patient's perception of meaningful improvements in pain and physical function.Convection-enhanced delivery of rhenium-186 (186Re)-nanoliposomes is a promising approach to provide precise delivery of large localized doses of radiation for patients with recurrent glioblastoma multiforme. Current approaches for treatment planning utilizing convection-enhanced delivery are designed for small molecule drugs and not for larger particles such as186Re-nanoliposomes. To enable the treatment planning for186Re-nanoliposomes delivery, we have developed a computational fluid dynamics approach to predict the distribution of nanoliposomes for individual patients. In this work, we construct, calibrate, and validate a family of computational fluid dynamics models to predict the spatio-temporal distribution of186Re-nanoliposomes within the brain, utilizing patient-specific pre-operative magnetic resonance imaging (MRI) to assign material properties for an advection-diffusion transport model. The model family is calibrated to single photon emission computed tomography (SPECT) images acquired during and after the infusion of186Re-nanoliposomes for five patients enrolled in a Phase I/II trial (NCT Number NCT01906385), and is validated using a leave-one-out bootstrapping methodology for predicting the final distribution of the particles. After calibration, our models are capable of predicting the mid-delivery and final spatial distribution of186Re-nanoliposomes with a Dice value of 0.69 ± 0.18 and a concordance correlation coefficient of 0.88 ± 0.12 (mean ± 95% confidence interval), using only the patient-specific, pre-operative MRI data, and calibrated model parameters from prior patients. These results demonstrate a proof-of-concept for a patient-specific modeling framework, which predicts the spatial distribution of nanoparticles. Further development of this approach could enable optimizing catheter placement for future studies employing convection-enhanced delivery.

The purpose of this study was to document the longitudinal strength and power characteristic changes and race performance changes of a skeleton athlete.

Longitudinal strength and power changes were assessed with strength and power diagnostic testing over a 9-year period. Trends over 9 years for relative strength were analyzed using a linear model. Push-start time was recorded across multiple tracks. Trends over 9 years for start performance at each track were assessed using a mixed-effects linear model to account for the impact of different tracks. Lower-body strength and power changes were assessed via a 1-repetition-maximum squat and a body-weight countermovement jump. The relationship between strength and power changes was assessed over time. The relationship between strength changes and start performance was determined by assessing the fixed effect of relative strength changes on push-start time.

Relative lower-body strength ranged from 1.6kg per body weight to 1.9kg per body weight and showed a significant mean improvement of 0.05kg per body weight per year (R2 = .71, P < .01). A negative correlation (R2 = .79) between relative strength changes and push-start performance across multiple tracks was found. The mixed-effects model indicated that push-start time improved significantly year to year (0.02s; P < .001; R2 = .74) when controlling for the effect of track.

The longitudinal analysis of push-start time and the associations with changes in strength suggest that training this quality can have a positive effect on push-start performance.

The longitudinal analysis of push-start time and the associations with changes in strength suggest that training this quality can have a positive effect on push-start performance.

Rising injury rates within football require further understanding of the etiological risk factors associated with lower-limb injury.

To examine the temporal pattern of recovery of directional dynamic stability measures post football-specific fatigue.

Eighteen male elite footballers completed baseline assessments of directional dynamic stability measures (Overall Stability Index, anterior-posterior stability [A-P], medial-lateral stability [M-L] on level 1 of the Biodex Stability System). IKK-16 Post Soccer-Specific Aerobic Field Test90 measures were repeated immediately, +24 hours, +48 hours, and +72 hours. The main effects for the recovery time and direction of stability were supplemented by regression modeling to describe the temporal pattern of recovery.

Significant main effects for time were identified for all directions of stability (Overall Stability Index, A-P, and M-L) up to +48 hours postexercise (P ≤ .05). The quadratic pattern of temporal recovery highlights a minimum of 37.55 to 38.67 hours and mime points, regardless of the fatigue exposure. Practitioners should consider the reduction of stability in this plane in relation to common mechanisms of injury in the knee to inform injury-risk-reduction strategies.

Patient expectations have been shown to be a major predictor of outcomes. Fulfilled expectations have been linked to increased patient satisfaction and rehabilitation adherence. Expectations may be influenced by a variety of factors, including patient characteristics, preoperative function, or disease characteristics. It is currently unknown what factors may influence patient expectations prior to cartilage repair of the knee, and to what degree. Furthermore, understanding the importance and values of those expectations for recovery using mixed methods has not previously been conducted in this patient population. The purpose of this mixed methods study is to examine and explore the relationships between patient expectations and functional outcome in patients undergoing cartilage repair of the knee.

A mixed methods design was used.

Twenty-one patients scheduled to undergo cartilage repair of the knee were included. Participants completed the Hospital for Special Surgery Knee Surgery Expectations Survey and the Knee Injury and Osteoarthritis Outcome Score at their preoperative visit.