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The Corona-Score is one of the first and most widely used predictive model for coronavirus 2 (SARS-CoV-2) infection. The purpose of this study was to validate the performance of Corona-Score in a cohort of Pakistani patients pursuing care for suspected infection.

After seeking institution's ethical committee exemption, results of serum lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin, absolute lymphocyte and neutrophil counts, chest x-ray findings and demographics of suspected COVID-19 cases with respiratory symptoms were recouped from electronic medical record. The pre-validated score as proposed by Kurstjens S et al., was calculated. The subjects were divided into SARS-CoV-2 positive and negative on the basis of reverse transcription-polymerase chain reaction (RT-PCR) findings. Median and interquartile range (IQR) was calculated for the score in the two groups and the difference was assessed using the independent sample median test. Receiver operating characteristics (ROC) curve analysis limited availability of PCR testing.

Corona-Score displayed a lower diagnostic accuracy which may be attributable to the different genetic framework, viral strain and severity of the disease in Pakistanis compared to the population where this score was originally validated. However, large multi-center studies across the country are dire need of time to evaluate the score in overly exhausted health care setup and limited availability of PCR testing.We assess the economic and health costs of COVID and policy responses to COVID. Based on initial estimates of health and economic costs, social distancing policies were justified, but these estimates now seem too high because of learning by doing. Significant differences in mortality rates across US states and countries can be explained by population density, climate, exposure, and policy. Regions that were able to contain the disease early have seen fewer deaths and lower economic losses. Some developing countries initially imposed drastic, costly measures, perhaps motivated by political economy. We also find that there has been underinvestment in prevention and mitigation that could have reduced the cost of adaptation and suggest that there is a lesson for climate change policies.Rapid urbanisation of Afghan cities without proper construction regulation has exposed their population to a high risk of damage from disasters such as earthquakes. With the growing construction of local non-engineered buildings and an existing level of hazard of 0.8 g, a high risk of casualties and building damage threatens Kabul in the event of a disaster. This study reports and evaluates a recent retrofitting project in Kabul City by 'Project for City Resilience', carried out under the supervision of the United Nation Human Settlements Program (UN-Habitat) for 48 retrofitted sun-dried clay brick masonry buildings in Kabul. The project was executed by local masons and welders who were trained as a part of the project, and the main tasks included installation of an additional steel frame, additional reinforced concrete foundation ring, ceiling replacement and wall strengthening (via mesh and plaster). After a visual assessment of retrofitted buildings considering the original retrofitting design and actual work done, a vulnerability index for retrofitted buildings was developed based on a behaviour modifier factor, which was assigned to each retrofitting activity using a combination of values and a proportion of scores for each retrofitting activity. The results indicate that training of local masons and welders to undertake retrofitting activities could decrease the damage ratio by 15% - 20% for peak ground acceleration values of 0.3 g and higher. The methods mentioned in this study can be used to make existing sun-dried clay brick masonry buildings sufficiently resistant to earthquakes of moderate-to-severe intensity.There are calls for better empirical models to inform climate change adaptation in smallholder agriculture. Hitherto adaptation studies have failed to comprehensively integrate non-cognitive behavioural factors (e.g. psychological capital), and there is also no common framework for measuring non-cognitive abilities of smallholder farmers. Hence, this study is the first attempt to assess how psychological capital affects climate change adaptation amongst smallholder farmers. Cisplatin The study estimated the multivariate probit regression model using data collected from 328 smallholder farmers in KwaZulu-Natal province, South Africa. The results show an association between some psychological capital indicators and smallholder adaptation decisions. Social networks, having multiple farming objectives, access to credit and the type of farmer (irrigators vs. non-irrigators) were also significant in determining smallholders' adaptation decisions. In conclusion, the study recommends the need for practical ways for enhancing smallholders' endowment with key non-cognitive abilities. There is also a need for researchers to develop a comprehensive framework for assessing non-cognitive factors critical for climate change adaptation. This will improve the use of positive psychology theories to advance the literature on climate change adaptation. Support should also be provided to communities facing higher risks of climate change adaptation. More focus should also be given to improve smallholder farmers' ability to adapt, including access to affordable credit. The role of social networks in information sharing remains critical, and hence their promotion should be prioritised. The findings on multiple objectives in farming were unique to climate change adaptation research, and hence the indicator should be considered in future similar studies.Many African countries face escalating challenges of increasing disaster risk and anticipated impacts of climate change. Although disaster risk reduction (DRR) and climate change adaptation (CCA) are tightly linked and comprising virtually identical practices in vulnerable countries in Southern Africa, research has identified parallel governance structures across the region. This study applied comparative case study research, based on 27 semi-structured interviews, to investigate the reasons for and effects of such parallel structures for DRR and CCA in Botswana, Mozambique, the Seychelles, Tanzania and Zambia. It revealed overwhelmingly negative effects in terms of unclear mandates and leadership, uncoordinated efforts, duplication of efforts, suboptimal use of resources and competition over resources and control. The study identified both external reasons for the parallel structures, in terms of global or international initiatives or incentives, and internal reasons, with regard to the history and quality of the governance structures.

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