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RESULTS A total of 162 abstracts were included for assessment of reporting, for which the mean OQS was 3.97 (SD, 1.30; 95 % CI, 3.77 to 4.17). According to multivariable analysis, origin from Europe (P=0.001) and reporting of the exact P value (P=0.020) were significantly associated with better reporting. Forty abstracts with statistically nonsignificant results for their primary outcome were included for spin evaluation, among which 34 (85.0%) had at least one type of spin. Thirty-two abstracts (94.1%) had spin in their conclusions section, and six abstracts (17.6%) had spin in the results section. CONCLUSIONS The reporting quality of RCT abstracts in Endodontics needs to be improved. The occurrence rate of spin in the sample of abstracts of RCTs in the field of Endodontics was high. Relevant stakeholders are recommended to be familiar with the CONSORT for Abstracts guideline and develop active strategies to ensure its implementation. This article is protected by copyright. All rights reserved.BACKGROUND Exposure to fine particulate matter (PM2.5 ) air pollution has been associated with skin-related diseases or disorders. OBJECTIVES To evaluate the potential skin protective effects of fish-oil supplementation against PM2.5 exposure. METHODS This is an exploratory analysis based on a pilot randomised, double-blind, placebo-controlled trial among 65 healthy young adults between September 2017 and January 2018 in Shanghai, China. We randomly assigned participants to intake either 2.5 g/day of fish oil or placebo for consecutive 4 months. Four rounds of skin D-squame tape samples were collected in the last 2 months, and 5 secondary biomarkers of skin inflammation and oxidative stress were measured. Fixed-site PM2.5 concentrations on campus were measured in real time. We used linear mixed-effect models to analyse the associations between short-term PM2.5 exposure and biomarkers in each group. RESULTS The 24-h average PM2.5 concentration was 34.68±15.83 μg/m3 . There were generally weaker associations between PM2.5 and biomarkers in the fish-oil group than in the placebo group, but the associations and the between-group differences varied by biomarkers and lag periods. Compared to the placebo group, for a 10-μg/m3 increase in PM2.5 , the increments of interleukin-1α and carbonyl protein in the fish-oil group were 41.55% smaller (95% confidence interval 4.61%, 78.48%) at lag 0-48 h and 22.01% smaller (95% confidence interval 11.25%, 32.77%) at lag 0-24 h, respectively. No significant between-group differences were observed for other biomarkers. CONCLUSIONS This study suggested that dietary fish-oil supplementation may improve biomarkers of skin inflammation and oxidative-stress response to short-term PM2.5 exposure. This article is protected by copyright. All rights reserved.BACKGROUND Youth whose parents have alcohol use disorder (AUD) are at higher risk for earlier initiation and greater magnitude of alcohol use, and have a higher likelihood of developing an AUD than their peers without parental history of AUD. This increased risk may be partly attributable to altered development of inhibitory control and related neural circuitry. This study examined neural activation during a motor response inhibition Stop Signal Task (SST) in substance-naïve youth aged 9 to 10 years with and without parental family history of AUD. Mirdametinib mouse METHODS Baseline cross-sectional survey and functional magnetic resonance imaging (fMRI) data was drawn from 6,898 youth in the US-based Adolescent Brain Cognitive Development Study. Generalized additive mixed models were conducted to examine the association between maternal, paternal, and parental (both mother and father) family history of AUD with neural activation during successful and failed response inhibition. Family history interactions with sex and stratificly inhibit a response as compared to children with no such family history. This unique neural response pattern could reflect a compensatory response and may represent an inherent neurobiological vulnerability to risk-related behaviors in these youth which will be examined in future longitudinal analyses of this cohort. This article is protected by copyright. All rights reserved.Anomalous origin of the right coronary artery (RCA) from the left sinus of Valsalva is a rare but clinically relevant congenital anomaly, since the RCA may be subjected to cyclical compression due to its interarterial course. At least in the past, most patients experienced bad outcomes before being diagnosed with a malignant variant. Chronic (often subclinical) myocardial ischemia and possible arrhythmias are common complications. Once symptoms or electrocardiographic signs of myocardial ischemia become apparent, a quick diagnosis is mandatory. We report the case of a late symptomatic woman in whom RCA originated from the opposite sinus of Valsalva. The malignant variant was confirmed at transesophageal echocardiography directly in the catheterization laboratory, soon after angiographic diagnosis of aberrant origin. © 2020 Wiley Periodicals, Inc.Hidradenitis suppurativa (HS) disproportionately affects women of childbearing age; however, there has been a paucity of literature in the field of HS and pregnancy.1 The objective of this study was to examine pregnancy complications, pregnancy outcomes, and neonatal outcomes in patients with HS. This article is protected by copyright. All rights reserved.Estimating temporal changes in a target population from phylogenetic or count data is an important problem in ecology and epidemiology. Reliable estimates can provide key insights into the climatic and biological drivers influencing the diversity or structure of that population and evidence hypotheses concerning its future growth or decline. In infectious disease applications, the individuals infected across an epidemic form the target population. The renewal model estimates the effective reproduction number, R, of the epidemic from counts of observed incident cases. The skyline model infers the effective population size, N, underlying a phylogeny of sequences sampled from that epidemic. Practically, R measures ongoing epidemic growth while N informs on historical caseload. While both models solve distinct problems, the reliability of their estimates depends on p-dimensional piecewise-constant functions. If p is misspecified, the model might underfit significant changes or overfit noise and promote a spurious understanding of the epidemic, which might misguide intervention policies or misinform forecasts.