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The hemodynamic variables obtained using the PiCCO system improved the accuracy of the bedside evaluations and led to alterations in the therapeutic plans, particularly among the hypotension patients. AHPNagonist The therapy changes showed no improvement in the overall mortality but were associated with improved tissue perfusion among the hypotension patients.

The hemodynamic variables obtained using the PiCCO system improved the accuracy of the bedside evaluations and led to alterations in the therapeutic plans, particularly among the hypotension patients. The therapy changes showed no improvement in the overall mortality but were associated with improved tissue perfusion among the hypotension patients.

This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1α (HIF-1α), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).

One hundred and thirty neonates with HIE admitted to our hospital from May 2017 to April 2019 were grouped into two groups according to the protocol of a randomized controlled trial, with 65 cases in each group. The control group received ganglioside treatment, while the combined group was treated with ganglioside + NGF for 2 weeks.

The total effective rate of treatment was higher in the combined group (90.77%) than in the control group (76.92%). The recovery time of sucking, consciousness, muscle tone and primitive reflexes was shorter in the combined group than in the control group, and the incidence of neurological sequelae was lower after 1 year in the combined group (4.62%) than in the control group (15.38%) (

< 0.05).

Gangliosides combined with NGF can promote the recovery of muscle tone and reduce neurological sequelae, which may possibly be achieved by repairing damaged neuronal cells, enhancing antioxidant enzyme activity, and promoting the regression of inflammation.

Gangliosides combined with NGF can promote the recovery of muscle tone and reduce neurological sequelae, which may possibly be achieved by repairing damaged neuronal cells, enhancing antioxidant enzyme activity, and promoting the regression of inflammation.

To evaluate the value of the non-predominant micropapillary and solid patterns in prognosis of lung adenocarcinoma.

Totally 422 patients diagnosed with stage IA lung adenocarcinomas were included, and all their slides were reviewed. We compared clinicopathological characteristics and survival outcomes between MP- & SD- (both micropapillary and solid component were absent), MP+/SD+ (either micropapillary or solid component was present, but the single or combined percentage of the MP and SD was not greater than 50%) and MPp/SDp (either micropapillary or solid or the combined percentage of these two components was great than 50%).

Patients with MP- & SD- had smaller tumor size (P=0.012) and lower spread through air spaces rates (P<0.001). Patients with MP- & SD- had significantly better 5-year recurrence free survival than MP+/SD+ (91% versus 70%, P<0.001) and MPp/SDp (91% versus 56%, P<0.001). The difference of RFS between MP+/SD+ subgroup and MPp/SDp subgroup was not significant (P=0.177). In the multivariate analysis, patients with MP- & SD- had a better recurrence free survival than the other two groups (versus MP+/SD+, HR, 3.198; 95% CI, 1.537-6.653; P=0.002; versus MPp/SDp HR, 4.981; 95% CI, 2.266-10.950; P<0.001).

The presence of micropapillary or solid patterns, even not predominant, was a risk factor for predicting poor recurrence free survival in very early stage lung adenocarcinoma.

The presence of micropapillary or solid patterns, even not predominant, was a risk factor for predicting poor recurrence free survival in very early stage lung adenocarcinoma.

This study set out to clarify the distribution and drug resistance of pathogens causing urinary tract infection (UTI) in patients with urinary calculi.

Pathogens were isolated from urine samples of patients with urinary calculi also complicated with UTIs, during the period from 2015 to 2019, and the samples were cultured for drug sensitivity testing to study the drug resistance of pathogens. The results were analyzed by SPSS 22.0 software.

Gram-negative bacteria were the main pathogens found in patients with urinary calculi complicated with UTI (84.52%). Escherichia coli, Enterococcus faecalis and Monilia albicans were the most common Gram-negative bacteria (48.84%), Gram-positive bacteria (34.78%) and fungus (29.41%), respectively. The UTI rates were higher in female patients than in male patients, and were higher in patients ≥ 60 years old compared with those < 60 years old. Escherichia coli and Klebsiella pneumoniae had the highest resistance to ampicillin and the lowest resistance to imipenem. En-infection management.

This study aimed to determine whether robot-assisted radical cystectomy (RARC) can accelerate recovery, improve pelvic lymph node dissection effects, and reduce serum tumor marker tumor specific growth factor (TSGF) levels in patients with bladder cancer.

A total of 96 patients with bladder cancer admitted to our hospital were recruited as the research participants. Among them, 43 patients who adopted radical cystectomy were enrolled in the control group (CG), and 53 patients treated with RARC were included in the research group (RG). link2 The operation time, intraoperative blood loss, postoperative bowel recovery time, gastrointestinal function recovery, complication rate, clinical efficacy, changes of TSGF levels before and after operation, postoperative satisfaction and quality of life were observed.

Compared with the CG, patients in the RG experienced longer operation times (P<0.05), less intraoperative blood loss (P<0.05), and faster time to bowel recovery, anal exhaust, and anal defecation (P<0.05); moreover, the RG had a lower incidence rate of complications (P=0.025) and TSGF levels (P<0.05), higher effective cure rate (P=0.023) and satisfaction degree (P=0.048), as well as superior quality of life scores in six dimensions (P<0.05).

The application of RARC can accelerate the recovery of patients with bladder cancer, improve the pelvic lymph node dissection effects, and reduce the serum levels of tumor marker TSGF.

The application of RARC can accelerate the recovery of patients with bladder cancer, improve the pelvic lymph node dissection effects, and reduce the serum levels of tumor marker TSGF.

To assess the computerized tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) fusion imaging technique features in cervical cancer staging and lymph node metastasis.

A total of 196 cervical cancer patients undergoing CT, MRI, PET/CT, and PET/MRI preoperatively were enrolled. The diagnostic accuracy and detection rates for paracervical invasion were evaluated on the basis of the International Federation of Gynecology and Obstetrics (FIGO) staging classification for cervical cancer. link3 The diagnostic efficacy of each examination modality for determining lymph node metastasis was evaluated using surgical pathology as a reference. The CT and MRI imaging features of lymph node metastasis were compared.

PET/MRI had a higher diagnostic accuracy for cervical cancer (94.90%) than PET/CT, MRI, and CT (83.67%, 75.51%, and 69.39%) (

< 0.05). PET/MRI showed a higher detection rate of vaginal invasion, uterine invasion, bladder invasion, and cervical invasion than PET/CT, MRI,PET/MRI has a higher diagnostic sensitivity, specificity, and accuracy and is helpful in clinical diagnosis and treatment.

This study was designed to investigate the application value of humanistic care interventions in patients with lower extremity arteriosclerosis obliterans (LEASO).

We enrolled 98 LEASO patients undergoing interventional therapy in our hospital into this study, among whom 47 cases received conventional care interventions (the regular group) while the other 51 received humanistic care interventions based on conventional care interventions (the research group). The two groups were compared in negative emotions, complications, and quality of life of patients.

Scores of negative emotions were lower in the research group than in the regular group after care (P < 0.05). The pain intensity decreased in both groups after care, with a sharper decrease in the research group (P < 0.05). The incidence of complications was lower in the research group than in the regular group after care (P < 0.05). The pain-free walking distance (PFWD) increased remarkably in both groups after care, with a longer PFWD in the research group than in the regular group (P < 0.05). Scores of the 36-Item Short-Form Health Survey (SF-36) increased after care in both groups (P < 0.05), with higher SF-36 scores in the research group than in the regular group (P < 0.05). SF-36 reflects the quality of life of patients from four aspects including vitality, emotional state, social function, and role-emotional. The care compliance and satisfaction level with care of patients were higher in the research group than in the regular group (P < 0.05). The care compliance rate and patient satisfaction level with care were higher in the research group than in the regular group (P < 0.05).

Humanistic care interventions can reduce postoperative pain intensity and improve the quality of life in patients with LEASO.

Humanistic care interventions can reduce postoperative pain intensity and improve the quality of life in patients with LEASO.

This study aimed to explore the effects of the atomization inhalation of budesonide (BUD), salbutamol (SAL), and ipratropium bromide (IB) on the T-lymphocyte subset and inflammatory cytokine levels in children with asthmatic pneumonia (AP).

A total of 118 children with AP admitted to our hospital were selected as the study cohort and randomly divided into two groups. The study group, included 67 patients who were treated with the atomization inhalation of BUD, SAL, and IB. The control group, included 51 patients who were treated with the atomization inhalation of BUD. The two groups were compared in terms of their symptom disappearance times, the therapeutic effects, inflammatory cytokine changes, their pulmonary function indices [C-reactive protein (CRP), respiratory frequency, forced vital capacity (FVC), one-second forced expiratory volume (FEV1), blood oxygen saturation (SpO2)], and their T-lymphocyte subset levels before and after the treatment, and the incidences of adverse reactions after the treatin treating children with AP, and it can improve their immune function and reduce their inflammatory cytokines levels.

To demonstrate that low-molecular-weight heparin (LMWH) can reduce the formation of lower limb deep venous thrombosis (DVT) and improve the quality of life (QOL) of patients with hypertensive intracerebral hemorrhage (HICH).

Totally, 98 patients with HICH were selected according to different treatment and intervention schemes. Patients receiving routine intracranial pressure reduction and blood pressure regulation intervention were included in group A (n=46) and those receiving LMWH calcium on the basis of treatment in group A were included in group B (n=52). The total effective rate of patients was compared between the two groups, and the prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen degradation product (FDP), D-dimer, and inflammatory factor levels as well as complications and QOL scores before and after treatment were recorded and compared.

The FDP and D-dimer showed an increasing trend in both groups after treatment, with the increase being significantly lower in group B than in group A (P<0.