Gyllingjohnston9413

However there was no association between VDR polymorphisms and glycemic status in south Indian type 2 diabetes patients.

AA and AG genotypes of FokI polymorphisms are associated with low serum 25 (OH) D levels. However there was no association between VDR polymorphisms and glycemic status in south Indian type 2 diabetes patients.In allometric studies, the joint distribution of the log-transformed morphometric variables is typically symmetric and with heavy tails. Moreover, in the bivariate case, it is customary to explain the morphometric variation of these variables by fitting a convenient line, as for example the first principal component (PC). To account for all these peculiarities, we propose the use of multiple scaled symmetric (MSS) distributions. These distributions have the advantage to be directly defined in the PC space, the kind of symmetry involved is less restrictive than the commonly considered elliptical symmetry, the behavior of the tails can vary across PCs, and their first PC is less sensitive to outliers. In the family of MSS distributions, we also propose the multiple scaled shifted exponential normal distribution, equivalent of the multivariate shifted exponential normal distribution in the MSS framework. For the sake of parsimony, we also allow the parameter governing the leptokurtosis on each PC, in the considered MSS distributions, to be tied across PCs. From an inferential point of view, we describe an EM algorithm to estimate the parameters by maximum likelihood, we illustrate how to compute standard errors of the obtained estimates, and we give statistical tests and confidence intervals for the parameters. We use artificial and real allometric data to appreciate the advantages of the MSS distributions over well-known elliptically symmetric distributions and to compare the robustness of the line from our models with respect to the lines fitted by well-established robust and non-robust methods available in the literature.

To present the consequences of and risk factors for abnormal bleeding after ECV (external cephalic version).

We conducted a retrospective chart review at a single center in Japan. Abnormal bleeding was defined as vaginal bleeding and/or intrauterine hemorrhage. We descriptively assessed birth outcomes among women with abnormal bleeding, and investigated the risk factors using a logistic regression analysis.

Of 477 women who received ECV, 39 (8.2%) showed abnormal bleeding, including 16 (3.4%) with intrauterine hemorrhage. Of the 16 women with intrauterine hemorrhage, 14 required emergency cesarean section; none experienced placental abruption, a low Apgar score at 5min (<7), or low umbilical cord artery pH (<7.1). Among 23 women who had vaginal bleeding without intrauterine hemorrhage, four cases underwent emergency cesarean section and one case of vaginal delivery involved placental abruption. The risk of abnormal bleeding was higher in women with a maximum vertical pocket (MVP) of <40mm in coormal bleeding.

Cytokine release syndrome in COVID-19 is due to a pathological inflammatory response of raised cytokines. Removal of these cytokines by therapeutic plasma exchange (TPE) prior to end-organ damage may improve clinical outcomes. This manuscript is intended to serve as a preliminary guidance document for application of TPE in patients with severe COVID-19.

The available literature pertaining to the role of TPE for treatment of COVID-19 patients was reviewed to guide optimal management. It included indication, contraindication, optimal timing of initiation and termination of TPE, vascular access and anticoagulants, numbers and mode of procedures, outcome measures and adverse events.

Out of a total of 78 articles, only 65 were directly related to the topic. From these 65, only 32 were acceptable as primary source, while 33 were used as supporting references. TPE in critically ill COVID-19 patients may be classified under ASFA category III grade 2B. The early initiation of TPE for 1-1·5 patient's plasma volume with fresh frozen plasma, or 4-5% albumin or COVID-19 convalescent plasma as replacement fluids before multiorgan failure, has better chances of recovery. The number of procedures can vary from three to nine depending on patient response.

TPE in COVID-19 patients may help by removing toxic cytokines, viral particles and/or by correcting coagulopathy or restoring endothelial membrane. Severity score (SOFA & APACHE II) and cytokine levels (IL-6, C-reactive protein) can be used to execute TPE therapy and to monitor response in COVID-19 patients.

TPE in COVID-19 patients may help by removing toxic cytokines, viral particles and/or by correcting coagulopathy or restoring endothelial membrane. Severity score (SOFA & APACHE II) and cytokine levels (IL-6, C-reactive protein) can be used to execute TPE therapy and to monitor response in COVID-19 patients.

To investigate the experience of Italian nurses during the first wave of the COVID-19 outbreak by analysing professional social media posts.

The COVID-19 outbreak has overwhelmed health care institutions; as a consequence, nurses' lives and psycho-physical health have been affected.

The COVID-19 pandemic forced nurses to work in physically and psychologically stressful conditions impacting on their life.

A qualitative descriptive study. selleck inhibitor All narratives (texts and videos) posted by nurses from the 23

of February 2020 to the 3

of May (from the start of the outbreak to the end of the first lockdown) were analysed and published on the five most popular Italian professional social media platforms. The Consolidated Criteria for Reporting Qualitative research guidelines were followed.

Five themes emerged from the 380 narratives explored 'Sharing what is happening within myself'; 'Experiencing unprecedented working conditions'; 'Experiencing a deep change'; 'Failing to rehabilitate the image of nurses inRSING PRACTICE, NURSING POLICY AND HEALTH POLICY Supporting nurses' mental health is highly recommended, together with a cultural investment on nurses' role recognition, and a zero-tolerance policy towards violence and aggression towards nurses.