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expand markedly.Carbonaceous matter, including organic carbon (OC) and black carbon (BC), is an important climate forcing agent and contributes to glacier retreat in the Himalayas and the Tibetan Plateau (HTP). Dorsomorphin cost The HTP - the so-called "Third Pole" - contains the most extensive glacial area outside of the polar regions. Considerable research on carbonaceous matter in the HTP has been conducted, although this research has been challenging due to the complex terrain and strong spatiotemporal heterogeneity of carbonaceous matter in the HTP. A comprehensive investigation of published atmospheric and snow data for HTP carbonaceous matter concentration, deposition and light absorption is presented, including how these factors vary with time and other parameters. Carbonaceous matter concentrations in the atmosphere and glaciers of the HTP are found to be low. Analysis of water-insoluable organic carbon and BC from snowpits reveals that concentrations of OC and BC in the atmosphere and glacier samples in arid regions of the HTP may be overestimated due to contributions from inorganic carbon in mineral dust. Due to the remote nature of the HTP, carbonaceous matter found in the HTP has generally been transported from outside the HTP (e.g., South Asia), although local HTP emissions may also be important at some sites. This review provides essential data and a synthesis of current thinking for studies on atmospheric transport modeling and radiative forcing of carbonaceous matter in the HTP.Human urine is a source of fertilizer and, with proper management, it can be reused in agriculture. Determining the contamination issue of antibiotics in source-separated urine is important because the majority of antibiotics are excreted with urine. In this study, source-separated urine samples were randomly collected from a male toilet in a university building and analyzed in terms of 30 typical antibiotics (including 14 sulfonamides, 4 tetracyclines, and 12 fluoroquinolones) and tetracycline-resistant Escherichia coli, as well as its antibiotic-resistant genes to determine the contamination characteristics of antibiotic-related pollution in fresh and stored urine. Results showed that 18 out of 30 typical antibiotics were detected in fresh source-separated human urine. The dominant antibiotic was oxytetracycline with a frequency of 100%, followed by tetracycline, sparfloxacin, enrofloxacin, and ofloxacin, which demonstrated a detection frequency of 55%. Among the detected values, sulfonamides (2 antibiotics), tetracyclines (4 antibiotics), and fluoroquinolones (12 antibiotics) had a concentration range of 0.25-2.94, 0.94-41.2, and 0.06-163.16 ng/mL, respectively. Furthermore, tetracycline-resistant Escherichia coli, which was measured using plate count method, and its related gene, tet M, exhibited a maximum cell density of (200,000 ± 5000) CFU/100 mL and (2.73 ± 0.261) × 107 copies/mL, respectively. When the fresh urine was stored in an ambient environment for 30 days to simulate the real circumstances of urine management, a significant reduction in antibiotics and antibiotic-resistant bacteria was observed, while the change in antibiotic-resistant genes was insignificant. The results of this study suggest that risks associated with antibiotics and their antibiotic-resistant bacteria and genes are retained during collection and storage. Hence, these kinds of microcontaminants must be considered in further urine utilization.Microplastics are particles smaller than five millimeters deriving from the degradation of plastic objects present in the environment. Microplastics can move from the environment to living organisms, including mammals. In this study, six human placentas, collected from consenting women with physiological pregnancies, were analyzed by Raman Microspectroscopy to evaluate the presence of microplastics. In total, 12 microplastic fragments (ranging from 5 to 10 μm in size), with spheric or irregular shape were found in 4 placentas (5 in the fetal side, 4 in the maternal side and 3 in the chorioamniotic membranes); all microplastics particles were characterized in terms of morphology and chemical composition. All of them were pigmented; three were identified as stained polypropylene a thermoplastic polymer, while for the other nine it was possible to identify only the pigments, which were all used for man-made coatings, paints, adhesives, plasters, finger paints, polymers and cosmetics and personal care products.A more precise understanding of individual-level heat exposure may be helpful to advance knowledge about heat-health impacts and effective intervention strategies, especially in light of projected increases in the severity and frequency of extreme heat events. We developed and interrogated different metrics for quantifying personal heat exposure and explored their association with social risk factors. To do so, we collected simultaneous personal heat exposure data from 64 residents of metropolitan Phoenix, Arizona. From these data, we derived five exposure metrics Mean Individually Experienced Temperature (IET), Maximum IET, Longest Exposure Period (LEP), Percentage Minutes Above Threshold (PMAT), and Degree Minutes Above Threshold (DMAT), and calculated each for Day Hours, Night Hours, and All Hours of the study period. We then calculated effect sizes for the associations between those metrics and four social risk factors neighborhood vulnerability, income, home cooling type, and time spent outside. We also actors, and health outcomes.In indoor environments, humans ingest chemicals present as surface residues and bound to settled particles (dust), through mouthing hands (hand-to-mouth transfer) and objects (object-to-mouth transfer). Here, we introduce a novel modeling approach in support of systematic investigation into the mouthing-mediated ingestion of chemicals present in indoor environments. This model explicitly considers the indoor dynamics of dust and chemicals, building on mechanistic links with physicochemical properties of chemicals, features of the indoor environment, and human activity patterns. The evaluation of this model demonstrates that it satisfactorily reproduces chemical hand loadings and exposure data reported in the literature. We then use the evaluated model to investigate the response of mouthing-mediated ingestion to chemical partitioning between the gas phase and solid phases, expressed as the octanol-air partition coefficient (KOA). Assuming a unit emission rate to the indoor environment, we find that low-volatility chemicals (with a KOA greater than 109) are more efficiently enriched in hand skin, resulting in higher mouthing-mediated ingestion than other compounds.

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