Griffinraynor2740

4%) vs 1(1.3%) cases,respectively (p less then 0.05). Conclusion In patients undergoing surgery for POP, the addition of SSLF did not result in an increased rate of de novo SUI. Careful patient selection, and informing the patients about the risks and benefits of the planned surgical procedure are essential steps in each case of POP.Introduction Mortality in the elderly population tends to be higher than in other age groups, but risk factor indices predicting mortality are not fully known.This large-scale clinical study aimed to identify risk factors affecting mortality, with particular focus on age and hospitalisation, and to demonstrate their effectiveness. Material and methods Patients with a clinical follow-up at 29 Mayıs State Hospital from July 2015 to January 2020 were retrospectively analysed. The missing or ambiguous records excluded. Age, gender, hospital length of stay, co-morbidity, consultation request and infectious diseases were investigated for their effectiveness on mortality. Through with the binary logistic regression analysis final results were obtained. Primary outcomes were factors affecting overall hospital mortality in elderly population. Results A total of 11430 patients,39.9% of whom were aged?65years. Risk factors for hospital mortality were identified in the elderly population; Consultation request and hospital length of stay of?4days showed the following findingsAdjusted odds ratio(AOR)[95% confidence limit(CI)]of[1.95(1.53,2.49)(P less then 0.001) and 2.49(1.90,3.26)(P less then 0.001)],respectively. Conclusion Among the predictive indices determined for mortality, the most important predictive risk factor in the elderly group is the duration of hospital stay, whereas compared to the young age group, being age of 65years old stands out in terms of risk.Background/aim; Overt thyroidism is known to cause neuropsychiatric disorders but studies on subclinical hyperthyroidism (SCH) are limited. Subclinical hyperthyroidism induction by administering L-Thyroxine (LT4) is the standard treatment method in differentiated thyroid carcinoma (DTC) follow-up. Our aim was to investigate whether anxiety, depression and quality of life are affected in DTC patients followed-up with exogenous SCH. Materials and methods The patients were divided into exogenous SCH by LT4 -DTC (n= 127), euthyroid-DTC (n= 66) and exogenous euthyroid- benign thyroid nodüle (BTN) who underwent thyroidectomy for benign thyroid pathology (n= 85) groups. Results The rate of moderate/severe anxiety was significantly higher in SCH-DTC than euthyroid-BTN group (27.5%, n= 35 vs. 9.4%, n= 8) (p= 0.001). TSH levels and Beck anxiety inventory (BAI) scores were significantly negatively correlated (p= 0.009 r= -0.16). Free T4 and BAI were significantly positively correlated (p= 0.04 r= 0.4). The groups were similar in terms of depression severity (p= 0.15). Subclinical hyperthyroid- DTC group scored significantly lower than euthyroid-BTN group in all scales of SF-36 quality of life survey. Conclusion LT4-induced SCH, which is a part of traditional DTC treatment, can exacerbate the anxiety symptoms in patients and disrupt their quality of life, depending on the level of fT4.Background/aim Premature birth is a major problem that results in increased risk of mortality and morbidity. read more Management of such infants consists of supraphysiological oxygen therapy, which affects brain development due, in part, to the deterioration caused by reactive oxygen species (ROS). We showed previously that exogenously-administered uridine provides neuroprotection in a neonatal rat model of hyperoxic brain injury. Hence, the aim of the present study was to investigate effects of uridine on ROS in the same setting. Materials and methods Hyperoxic brain injury was induced by subjecting total 53 six-day-old rat pups to 80% oxygen (Hyperoxia group) for a period of 48 hours. Pups in Normoxia group continued breathing room air (21% oxygen). Normoxia+saline or hyperoxia + saline or hyperoxia + uridine100 mg/kg or hyperoxia + uridine300 mg/kg or hyperoxia + uridine500 mg/kg was injected intraperitoneally (i. p.) 15 minutes prior to hyperoxia procedure. Pups were decapitated and brains were homogenized to analyze Superoxide Dismutase (SOD), Glutathione Peroxidase (GSH-Px), Myeloperoxidase (MPO) and Malondialdehyde (MDA) enzymes as well as DJ-1 (Protein deglycase DJ-1), an oxidative stress sensitive protein. Results Hyperoxia-induced may cause overproduction of oxygen radicals and the oxidant / antioxidant balance may be disturbed in the brain. Brain MPO and MDA levels were significantly increased in saline-receiving pups exposed to hyperoxia. Brain SOD and GSH-Px levels were significantly decreased in saline-receiving pups exposed to hyperoxia. Our results showed that uridine administration prevented the hyperoxia-induced decrease in SOD and GSH-Px while counteracting the hyperoxia-induced increase in MPO and MDA in a dose-dependent manner. Uridine also increased DJ-1 levels in brains of rat pups subjected to hyperoxia. Conclusion These data suggest that uridine exhibits antioxidative properties which may mediate the protective effects of uridine in a neonatal rat model of hyperoxic brain injury.Background/aim Diagnosis of interstitial lung diseases requires a multidisciplinary aproach and a gold standard for histological diagnosis is open lung biopsy. Transbrochial lung biopsy (TBLB) and in recent years an alternative method cryobiopsy (TBLC) are used for the diagnosis of parenchymal lung lesions. The aim of this study is to compare the efficacy of concomitant conventional TBLB and TBLC. Materials and methods A total of 82 patients who underwent TBLC for diagnosis of diffuse parenchymal lung diseases at Dr. Suat Seren Chest Diseases and Surgery Train-ing and Research Hospital between 2015 and 2018 were screened retrospectively and included in the study. 53.7% (n44) of the patients were male ,and 46.4% (n38) of them were female The mean age was 58.37 (± 9.33) years. First TBLB and then TBLC were performed to all patients in the same session and their diagnostic performance was compared. Results Although both procedures were done in the same session 45 patients (54.9%) were diagnosed with TBLB and 75 patients (91.