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Short-term exposure to ambient air pollution has been linked to occurrence of myocardial infarction (MI); however, only a limited number of studies investigated its association with death from MI, and the results remain inconsistent.

This study sought to investigate the association of short-term exposure to air pollution across a wide range of concentrations with MI mortality.

A time-stratified case-crossover study was conducted to investigate 151,608 MI death cases in Hubei province (China) from 2013 to 2018. Based on each case's home address, exposure to particulate matter with an aerodynamic diameter≤2.5μm (PM

), particulate matter with an aerodynamic diameter≤10μm (PM

), sulfur dioxide, nitrogen dioxide (NO

), carbon monoxide, and ozone on each of the case and control days was assessed as the inverse distance-weighted average concentration at neighboring air quality monitoring stations. Conditional logistic regression models were implemented to quantify exposure-response associations.

Exposure to PM

, PM

, and NO

(mean exposure on the same day of death and 1day prior) was significantly associated with increased odds of MI mortality. The odds associated with PM

and PM

exposures increased steeply before a breakpoint (PM

, 33.3μg/m

 ; PM

, 57.3μg/m

) and flattened out at higher exposure levels, while the association for NO

exposure was almost linear. Each 10-μg/m

increase in exposure to PM

(<33.3μg/m

), PM

(<57.3μg/m

), and NO

was significantly associated with a 4.14% (95% confidence interval [CI] 1.25% to 7.12%), 2.67% (95%CI 0.80% to 4.57%), and 1.46% (95%CI 0.76% to 2.17%) increase in odds of MI mortality, respectively. Onvansertib molecular weight Theassociation between NO

exposure and MI mortality was significantly stronger in older adults.

Short-term exposure to PM

, PM

, and NO

was associated with increased risk of MI mortality.

Short-term exposure to PM2.5, PM10, and NO2 was associated with increased risk of MI mortality.

Tricuspid regurgitation (TR) is a frequent disease with a progressive increase in mortality as disease severity increases. Transcatheter therapies for treatment of TR may offer a safe and effective alternative to surgery in this high-risk population.

The purpose of this report was to study the 1-year outcomes with the TriClip transcatheter tricuspid valve repair system, including repair durability, clinical benefit and safety.

The TRILUMINATE trial (n=85) is an international, prospective, single arm, multicenter study investigating safety and performance of the TriClip Tricuspid Valve Repair System in patients with moderate or greater TR. Echocardiographic assessment was performed by a core laboratory.

At 1 year, TR was reduced to moderate or less in 71% of subjects compared with 8% at baseline (p<0.0001). Patients experienced significant clinical improvements in New York Heart Association (NYHA) functional class I/II (31% to 83%, p<0.0001), 6-minute walk test (272.3 ± 15.6 to 303.2 ± 15.6 meterth low mortality after 1 year in a fragile population that was at high surgical risk. (TRILUMINATE Study With Abbott Transcatheter Clip Repair System in Patients With Moderate or Greater TR; NCT03227757).

The aim of this study was to evaluate early results of valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) versus redo surgical aortic valve replacement (SAVR) for structural valve degeneration (SVD).

ViV TAVR has been increasingly used for SVD, but it remains unknown whether it produces better or at least comparable results as redo SAVR.

Observational studies comparing ViV TAVR and redo SAVR were identified in a systematic search of published research. Random-effects meta-analysis was performed, comparing clinical outcomes between the 2 groups.

Twelve publications including a total of 16,207 patients (ViV TAVR, n = 8,048; redo SAVR, n = 8,159) were included from studies published from 2015 to 2020. In the pooled analysis, ViV TAVR was associated with lower rates of 30-day mortality overall (odds ratio [OR] 0.53; 95% confidence interval [CI] 0.32 to 0.87; p=0.017) and for matched populations (OR 0.419; 95%CI 0.278 to 0.632; p=0.003), stroke (OR 0.65; 95%CI 0.55 to 0.76; p<0.001), peres of myocardial infarction and severe patient-prosthesis mismatch.

This study sought to evaluate the incidence and causes of percutaneous coronary intervention (PCI) at different time periods following transcatheter aortic valve replacement (TAVR).

Coronary artery disease (CAD) and aortic stenosis frequently coexist, but the optimal management of CAD following TAVR remains incompletely elucidated.

Patients undergoing unplanned PCI after TAVR were retrospectively included in an international multicenter registry.

Between July 2008 and March 2019, a total of 133 patients (0.9%; from a total cohort of 15,325) underwent unplanned PCI after TAVR (36.1% after balloon-expandable bioprosthesis, 63.9% after self-expandable bioprosthesis). The median time to PCI was 191 days (interquartile range 59 to 480 days). The daily incidence of PCI was highest during the first week after TAVR and then declined over time. Overall, the majority of patients underwent PCI due to an acute coronary syndrome, and specifically 32.3% had non-ST-segment elevation myocardial infarction, 15.4% had ereafter chronic coronary syndromes become prevalent. Unplanned PCIs are frequently successfully performed after TAVR, with no apparent differences between balloon-expandable and self-expandable bioprostheses. (Revascularization After Transcatheter Aortic Valve Implantation [REVIVAL]; NCT03283501).

The purpose of this study was to assess the concordance between transcatheter aortic valve implantation angles generated by the "double S-curve" and "cusp-overlap" techniques.

The "double S-curve" and "cusp-overlap" methods aim to define optimal fluoroscopic projections for transcatheter aortic valve replacement (TAVR) with a self-expandable device.

The study included 100 consecutive patients undergoing TAVR with self-expanding device planned by multidetector computed tomography. TAVR was performed using the double S-curve model, as a view in which both the aortic valve annulus and delivery catheter planes are displayed perpendicularly on fluoroscopy. Optimal projection according to the cusp-overlap technique was retrospectively generated by overlapping the right and left cups on the multidetector computed tomography annular plane. The angular difference between methods was assessed in spherical 3 dimensions and on the left and right anterior oblique (RAO) and cranial and caudal (CAU) axes.

The double S-curve and cusp-overlap methods provided views located in the same quadrant, mostly the RAO and CAU, in 92% of patients with a median 3-dimensional angular difference of 10.