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Mantle cell lymphoma (MCL) is a heterogenous disease with a variety of morphologic and genetic features, some of which are associated with high risk disease. Here we critically analyze the current state of the understanding of MCL's biology and its implications in therapy, with a focus on chemotherapy-free and targeted therapy regimens.

Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin's lymphoma, defined by a hallmark chromosomal translocation t(11;14) which leads to constitutive expression of cyclin D1. Recent discoveries in the biology of MCL have identified a number of factors, including TP53 mutations and complex karyotype, that lead to unresponsiveness to traditional chemoimmunotherapy and poor outcomes. Bruton tyrosine kinase inhibitors, BH3-mimetics and other novel agents thwart survival of the neoplastic B-cells in a manner independent of high-risk mutations and have shown promising activity in relapsed/refractory MCL. These therapies are being investigated in the frontline setting, whi are being investigated in the frontline setting, while optimal responses to chemotherapy-free regimens, particularly in high-risk disease, might require combination approaches. High-risk MCL does not respond well to chemoimmunotherapy. Targeted agents are highly active in the relapsed refractory setting and show promise in high-risk disease. Novel approaches may soon replace the current standard of care in both relapsed and frontline settings.Replenishing soil nutrient particularly total nitrogen (TN) and available phosphorus (P) is important to sustain soil health for food production. Organic amendments such as compost and biochar are commonly applied to improve soil nutrient retention especially N and P. In farms, biochar is usually applied once followed by applying other organic amendment applied in their full rates. Both form and rate of organic amendments can affect soil nutrient concentrations particularly in short term. This study aimed to examine the effects of compost and mixture of compost with biochar (both at full rates) on soil nutrient concentrations in short term. A randomised complete block filed experiment with eight replicates was used for this study. The effects of biochar (5 t/ha) only, compost (at the rates of 10 t/ha, 25 t/ha and 35 t/ha) and biochar mixed with compost (5 t/ha and 10 t/ha, respectively) on soil nutrient concentrations compared with control were explored in a corn field. Compost treatment at the rate of 35 t/ha had significantly higher TN, available P, calcium (Ca) and iron (Fe) compared with other treatments and control. Soil potassium (K) levels remained unchanged among all treatments. Biochar only treatment had significantly higher available P and Ca concentrations compared with biochar mixed with compost treatment. Compost application at higher rate (35 t/ha) proved best practice to significantly increase TN and available P concentrations in short term. Significantly higher available P concentration in biochar only treatment compared with the biochar mixed with compost treatment could have been associated with stimulation of P immobilisation when biochar was mixed with compost. Our results indicated that the form and rate of organic amendments in short term cropping systems are important to be considered while applying to a volcanic soil to ensure N and P availability for plants are not compromised.The central theme of the study is to assess the socioeconomic impact of household biogas plants on rural households. To this end, the study selected respondents from biogas plant holders and non-holders of biogas plants in rural areas of Muzaffar-Garh. During the field survey, a questionnaire survey was conducted on 40 biogas users in two villages in each Tehsil and 40 non-biogas users in the same village. A survey based on pre-designed questionnaire was conducted, and main data of 320 households in four Tehsil districts (interviewees) in the Muzaffar-Garh region were collected. In this study, biogas is the input variable, while elderly education and total household income are the input socioeconomic variables. Farm productivity, time saving, indoor air pollution, household hygiene, and expenditure are intermediate variables. The output variables include income, health, and education level of minor children aged 2-5 years. Structural equation modeling (SEM) techniques that describe the relationship between input variables and output variables can be used to obtain steadfast results. Based on the estimates, we have observed that BG investments have substantial impacts on farm productivity, time savings, indoor air pollution, household hygiene, and expenditure, which in turn has played a role in improving the status of people. It is concluded that many direct and indirect socioeconomic impacts of holding biogas plants on rural households can be measured. In order to widely promote biogas technology as an alternative energy source nationwide, there must be greater public participation.Pesticides may cause a potential risk to human health when applied in excess to control pests, diseases, and weeds in crop fields. learn more In the current study, conducted in the Aegean region of Turkey from 2012 to 2016, a total of 3044 samples of 16 different commodities of fruits and vegetables were screened to identify pesticide residues and health risk to consumers posed by such residues was assessed. Results showed that 354 samples out of the total samples had higher maximum residue limit (MRL) values, while the MRL values were lower in 473 samples. In the study, residues of 64 different pesticides detected in 3044 samples in which 11.6% samples exceeded maximum residue limit (MRL) levels as compared with that of the approved MRL level by the Turkish authorities. Out of total samples, number of samples having high MRL level were as follows 74 for chlorpyrifos (2.43%), 145 for azoxystrobin (3.8%), 112 for triadimenol (3.8%), 103 for carbendazim (3.4%), 98 for chlorpyrifos (3.2%), 94 for pyrimethanil (3.10%), 90 for cyprodinil (2.9%), 76 for fludioxonil (2.50%), 75 for indoxacarb (2.40%), 66 for imidacloprid (2.10%), and 60 for boscalid (1.90%). Residues of one, two, three, four, and even more than five pesticides were detected, respectively, in 16.1, 5.8, 2.8, 1, and 1.7% of the total test samples. The lowest estimated daily intake (EDI) values ranged from 3.57×10-3 to 8.98. The lower values of hazard quotient (HQ) were obtained in dried apricot, grape, and strawberry with the value of 0.01, although the HQ value in 32 out of 62 pesticides tested was found to be close to 0.