Georgewitt3641

. Herein, we provide a discussion of the redox and metabolic control of T-lymphocytes as separate entities, as well as coupled to one another, to regulate adaptive immunity. While investigations examining this pair together in T-lymphocytes are sparse, we speculate that T-lymphocyte destiny is shaped by the redox-metabolic couple. In contrast, disrupting this duo may have inflammatory consequences such as hypertension.Continued chromatographic investigation of Calendula officinalis flowers led to the isolation of two sesquiterpenes, including one new, viridiflorol-10-O-β-quinovopyranoside-2`-O-(3``-methyl-2``-pentenoate) (1), along with a previously reported compound viridiflorol-10-O-β-fucopyranoside-2`-O-(3``-methyl-2``-pentenoate) (2). The new compound 1 was tested for antiprotozoal activity against Leishmania donovani Amastigote/THP1 and Trypanosoma brucei and it showed IC50 values of 3.57 and 7.84 µg/mL, respectively, while compound 2 exhibited no activity at the highest concentration tested 10 µg/mL.BACKGROUND Pregnancy after heart transplantation (HT) is a concern for many female recipients. The International Society for Heart and Lung Transplantation has guidelines regarding reproductive health, but limited data exist regarding providers' attitudes and practices surrounding pregnancy post-HT. METHODS We conducted an independent, confidential, voluntary, web-based survey sent electronically to 1643 United States heart transplant providers between June and August 2019. RESULTS There were 122 responses, the majority from cardiologists (n=85, 70%) and nurse or transplant coordinators (n=22, 18%). Thirty-one percent (n=37) of respondents indicated that pregnancy should be avoided in all HT recipients, and only 43% (n=52) reported that their center had a formal policy regarding pregnancy following HT. The most commonly reported contraindications included nonadherence (n=109, 89%), reduced left ventricular ejection fraction (n=104, 85%), coronary allograft vasculopathy (n=86, 70%), prior rejection (n=76, 62%), presence of donor-specific antibodies (n=69, 57%), and prior peripartum cardiomyopathy pretransplant (n=57, 47%). Respondent sex, specialty, transplant volume, or prior experience with pregnancy after HT were not associated with recommendations to avoid posttransplant pregnancy. CONCLUSIONS Transplant providers' attitudes regarding posttransplant pregnancy vary widely. Despite International Society for Heart and Lung Transplantation guidelines, a significant proportion indicates that pregnancy is contraindicated in all recipients and the majority of programs have no center-specific policy to manage such pregnancies. While the low response rate limits the generalizability of the findings, they do suggest that education on the feasibility of pregnancy post-HT is indicated as many recipients are of, or survive to, childbearing age.INTRODUCTION Rural and remote Australia has long been recognised as an area with reduced help-seeking for mental health concerns and an increased suicide mortality. The current study aimed to investigate the differences between help-seeking intentions and predictors between different locations across Australia to better understand the barriers to seeking help for rural residents. METHODS An anonymous online survey measuring attitudes, stoicism, help-seeking intentions and demographics was conducted through various channels across Australia. Differences between locations and relationships between variables of interest were analysed using multiple regression and mediation analysis. RESULTS In total, 471 participants were included in the analysis, the majority residing in outer regional areas (37.4%), followed by inner regional areas (29.9%), major cities (18.3%), remote areas (12.3%) and very remote areas (2.1%). Location, along with attitudes and stoicism, were predictors of help-seeking. A novel mediation model revealed that attitudes partially mediated the association between stoicism and lower help-seeking intentions for both rural and urban participants. CONCLUSION Findings from this study extend knowledge of what differentiates people who are willing from those who are not willing to seek help for a mental health concern or suicidal ideation, by their living location. The findings also suggest practical implications for clinical intervention and community prevention that could assist improving help-seeking for rural Australians in the future.INTRODUCTION Peru has experienced a significant internal migration from rural to urban areas in recent years. This study estimates the prevalence of depressive symptoms in Peruvian women of childbearing age and their probability of having these symptoms according to the condition of internal migration. METHODS Data from the 2014-2018 Demographic and Family Health Survey (ENDES) was used. Depressive symptoms were measured using the Patient Health Questionnaire (PHQ-9). Adjusted odds ratios and the marginal effects were estimated to assess associated factors and the probability of having depressive symptoms in relation to internal migration status, respectively. RESULTS The prevalence of depressive symptoms (PHQ-9≥10 points) decreased from 2014 to 2018, as did the prevalence of these symptoms for all the internal migration status. There was a positive relationship between the post-migration residence time and the probability of having depressive symptoms. Furthermore, compared to women in rural areas who never migrated, all of the other migrant statuses were associated with an increased probability of depressive symptoms. Other factors such as being the head of the household, being married/cohabiting or separated/divorced/widowed, smoking, alcohol consumption, diabetes, having an impairment and living at levels of altitude greater than 500 m were associated with a higher probability of having depressive symptoms. CONCLUSION Despite a reduction in the overall burden of depressive symptoms, the migrant subgroup population has a higher probability of presenting these symptoms. Mental health strategies for migrant women are a priority in Peru.As Asian Americans continue to be one of the fastest growing populations in a rapidly diversifying United States (Lee, 2015), understanding how Asian American parents socialize their children about race and racism and how this contributes to development remains an important question (Chang, 2016; García Coll et al., 1996). Using a sample of 228 Asian American emerging adults (70% female, Mage = 20.23), we examined profiles of parental racial-ethnic socialization messages and their relationships with racial-ethnic identity and social connectedness outcomes. Results suggested 3 profiles. The guarded separation socialization group reported receiving the most frequent messages about maintaining their heritage culture and avoiding outgroups. The passive and active integration socialization groups also received frequent messages about maintaining heritage culture, but very few messages about avoiding outgroups or minimizing the significance of race. The active integration socialization group received the most messages about becoming American, treating everyone equally, and respecting diverse cultures, compared to the passive integration socialization group, which reported receiving few of these messages. Participants in the active integration profile reported significantly higher levels of cognitive clarity and affective pride regarding their racial-ethnic identity compared to the other two profiles, while individuals in the passive and active integration profiles reported significantly higher levels of social connectedness than those in guarded separation profile. These findings highlight the importance of using a holistic lens to understand Asian American youths' perceptions of how their parents engage in racial-ethnic socialization across multiple domains. (PsycInfo Database Record (c) 2020 APA, all rights reserved).High patient emotional arousal during rationale development for in vivo exposure in CBT for panic disorder with agoraphobia might endanger comprehension of the exposure rationale. Since therapists are supposed to coregulate patients' emotions, this study investigated whether there was evidence of coregulation of vocally encoded emotional arousal, assessed by fundamental frequency (f0), during rationale development. Furthermore, the association of patient f0 stability and therapist coregulation with patients' perceived rationale plausibility was analyzed. N = 197 therapy videos-used to deduct f0-from a multicenter randomized controlled trial evaluating therapist-guided exposure on CBT outcome were analyzed post hoc. Plausibility of the exposure rationale was assessed by patients after its development. This trial-specific rating aggregates plausibility ratings for every manual component in the development of the exposure rationale and showed good internal consistency (Cronbach's alpha = .85). Stability in f0 and its coregulation were calculated using cross-lagged Actor-Partner Interdependence Models (APIMs), and APIM dyad estimates were associated with plausibility using linear regression analyses. Analyses indicated a relative stability in emotional arousal within both patients and therapists. Therapists' f0 had a significant effect on patients in that with therapist covariation, patients' f0 departed from their equilibrium level, while patients' f0 had no effect on therapists. Therapists' f0 covariation was positively associated with rationale plausibility. This study sheds light on interpersonal regulation mechanisms of patients' and therapists' emotional arousal during development of the exposure rationale. It suggests that coregulation of patients' emotional arousal supports patients' perceived rationale plausibility. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Scholars have proposed 2 separable dimensions of racial colorblind ideology the first is centered on "not seeing color" (i.e., color evasion), and the second is centered on denying racism (i.e., power evasion). Yet, to date, there is no psychometric evidence for this distinction. In this article, we aim to fill this gap by establishing the presence of and characterizing differences between these 2 dimensions using both variable-centered and person-centered approaches. Study 1A (n = 707) provides exploratory factor analytic evidence supporting the separability of power and color evasion. Study 1B (n = 710) provides confirmatory evidence of this factor structure and evidence of discriminant validity. In Study 1B, 3 latent profiles based on power and color evasion were identified acknowledgers (low color evasion, low power evasion), evaders (high color evasion, average power evasion), and deniers (average color evasion, average power evasion), which differed on relevant variables (e.g., modern racism, support for affirmative-action). In Study 2 (n = 546), these profiles were replicated and extended by examining differences in attitudes and desire to engage in campus diversity activities. Implications for racial colorblind ideology theory and practical applications are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).The Reading the Mind in the Eyes task (RMET; Baron-Cohen, Wheelwright, Hill, Raste, & Plumb, 2001) is commonly used to assess theory of mind abilities in adults. In the task, participants pair one of four mental state descriptors with a picture of the eye region of a face. The items have varying emotional valence, and nearly 100 studies have examined whether performance on this task varies with item valence. However, efforts to address this question have been hampered by cross-study inconsistencies in how item valence is assessed. Thus, the goal of this study was to establish reference ratings for the valence of RMET items. In Study 1, we recorded valence ratings for each RMET item with a large sample of raters (n = 164). We illustrated how valence categories are essentially arbitrary and largely influenced by sample size. In addition, valence ratings were continuously distributed, further questioning the validity of imposing categorical distinctions. In Study 2, we used an archival dataset to demonstrate how the different categorization schemes resulted in conflicting conclusions about the association between item valence and RMET performance.