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he procedure (p=0.04).

Ultrasound-guided percutaneous liver biopsy is an efficacious and safe technique for the histological diagnosis of space-occupying liver lesions. Our results confirm the increased rate of complications when patients fail to cooperate during the procedure.

Ultrasound-guided percutaneous liver biopsy is an efficacious and safe technique for the histological diagnosis of space-occupying liver lesions. Our results confirm the increased rate of complications when patients fail to cooperate during the procedure.

To contribute our results to increase the scientific evidence about the use of radioembolization in the management of patients with hepatocellular carcinoma.

This retrospective review included 53 patients with hepatocellular carcinoma treated with radioembolization at our center. Patients were classified according to the BCLC algorithm in detail according to their Child-Pugh functional status. We analyzed survival using the Kaplan-Meier method. We used Cox regression analysis to determine clinically significant parameters, including the doses administered in the parameters studied.

Patients ranged in age from 28 to 86 years (mean, 60 years). A total of 61 procedures were done. The mean activity administered was 2.8 GBq (0.7-6.4 GBq), with a mean dose of 229.9Gy (74-425.9Gy) administered in the tumor. Progression-free survival was 6.7 months and overall survival was 12.8 months. Differences in disease-free survival according to BCLC and Child-Pugh classification were not significant (p=0.848 and p=0.252, respectively). The clinical parameters that were significantly different with respect to overall survival were bilirubin levels (p<0.001), pretreatment transaminase levels (AST) (p=0.022), Child-Pugh subclassification (p=0.003), and dose administered in the tumor (p=0.001). Only one patient had a severe adverse reaction, developing posttreatment liver failure resulting in death.

Radioembolization is safe and efficacious in the treatment of patients with hepatocellular carcinoma. Liver function and the doses received by the tumor are key parameters for the efficacy of treatment. The increase in the scientific evidence supports the inclusion of this technique in treatment guidelines.

Radioembolization is safe and efficacious in the treatment of patients with hepatocellular carcinoma. Liver function and the doses received by the tumor are key parameters for the efficacy of treatment. The increase in the scientific evidence supports the inclusion of this technique in treatment guidelines.Lung cancer patients are at heightened risk for developing COVID-19 infection as well as complications due to multiple risk factors such as underlying malignancy, anti-cancer treatment induced immunosuppression, additional comorbidities and history of smoking. Recent literatures have reported a significant proportion of lung cancer patients coinfected with COVID-19. Chloroquine, hydroxychloroquine, lopinavir/ritonavir, ribavirin, oseltamivir, remdesivir, favipiravir, and umifenovir represent the major repurposed drugs used as potential experimental agents for COVID-19 whereas azithromycin, dexamethasone, tocilizumab, sarilumab, famotidine and ceftriaxone are some of the supporting agents that are under investigation for COVID-19 management. The rationale of this review is to identify potential drug-drug interactions (DDIs) occurring in lung cancer patients receiving lung cancer medications and repurposed COVID-19 drugs using Micromedex and additional literatures. This review has identified several potential DDIs that could occur with the concomitant treatments of COVID-19 repurposed drugs and lung cancer medications. This information may be utilized by the healthcare professionals for screening and identifying potential DDIs with adverse outcomes, based on their severity and documentation levels and consequently design prophylactic and management strategies for their prevention. Identification, reporting and management of DDIs and dissemination of related information should be a major consideration in the delivery of lung cancer care during this ongoing COVID-19 pandemic for better patient outcomes and updating guidelines for safer prescribing practices in this coinfected condition.Endogenous pollution from sediments is gradually becoming a critical pollution source of the drinking water reservoir. Odorants can be released from sediments into the overlying water which further deteriorate the water quality of the drinking water reservoir. In this work, we set the sediment-overlying water systems under various water pH (6.5, 8 and 9), temperature (4, 20 and 30 °C) during 30 days and intermittent or continuous hydraulic disturbances (at 100 r/min or 200 r/min) in 5 days, and investigated the dynamic release of odorants from the drinking water reservoir sediments via using headspace solid-phase microextraction (HSPME) and gas chromatography-mass spectrometry (GC-MS). The result shows that weakly alkaline environment slightly but not significantly increased the concentration of dimethyl disulfide (DMDS) in the overlying water. Furthermore, low temperature promoted the release of bis(2-chloroisopropyl) ether (BCIE) and geosmin to 108.36 and 18.98 ng/L, respectively, while high temperature facilitated the DMDS release to 20.33 ng/L. Notably, hydraulic disturbances drastically elevated the level of seven odorants released from the sediments. Specially, benzaldehyde exhibited highest concentration at 260.50 ng/L. The continuous disturbance greatly enhanced the release of benzaldehyde, DMDS, dimethyl trisulfide (DMTS), BCIE and 1,4-dichloro-benzene (1,4-DCB) from sediments with a positive disturbance speed-dependence. However, the intermittent disturbance promoted higher level of geosmin in the overlying water compared to the continuous disturbance. Only continuous hydraulic disturbance at high speed could lead to the release of ethylbenzene from sediments, which was up to 4.89 ng/L in 12 h.

Thallium is a widely known toxic heavy metal that has been reported have embryo toxicity.

We aimed to investigate the relationship of prenatal thallium exposure with neonatal telomere length.

A total of 746 mother-newborn pairs were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. Maternal thallium exposure levels were measured in spot urine samples collected during the three trimesters and during hospital delivery using inductively coupled plasma mass spectrometry. Neonatal relative telomere length (rTL) was measured by a real-time quantitative polymerase chain reaction assay in cord blood. Multiple informant models were used to evaluate the association of maternal thallium exposure with neonatal rTL.

After adjustment for multiple potential confounders, each 25% incremental increase of maternal thallium exposure, measured in urine samples collected during hospital delivery, was associated with a 1.85% shortened neonatal rTL (95% CI-3.62%,-0.05%; P=0.044). Similarly, mothers in the highest quartile of urinary thallium exposure had a 11.74% (95% CI-21.57%,-0.68%; P=0.038) shorter cord blood leukocyte rTL than those in the lowest quartile. However, no significant association was found between neonatal rTL and maternal thallium exposure measured in urine samples collected during the three trimesters of pregnancy.

This study reveals that prenatal thallium exposure was related to shortened neonatal telomere length in Chinese population, pointing to the important role of thallium exposure in accelerating biological aging.

This study reveals that prenatal thallium exposure was related to shortened neonatal telomere length in Chinese population, pointing to the important role of thallium exposure in accelerating biological aging.Phenanthrene contaminated soil was remediated by the photochemical process of ferrous oxalate. Without using H2O2 and adjusting soil pH, phenanthrene in contaminated soil was degraded effectively by the ferrous oxalate under visible light irradiation. Ferrous oxalate possesses excellent visible light absorption ability which benefits the degradation of phenanthrene in soil under visible light irradiation. Via the Fe(II)/Fe(III) catalytic cycle of ferrous oxalate, H2O2 and Fe(II) could be produced continuously and H2O2 was further catalyzed by Fe(II) and released hydroxyl radicals (•OH) to degrade the phenanthrene in soil. The dosage of ferrous oxalate, moisture content of soil, and soil thickness were most important factors for degradation of phenanthrene in soil. In addition, a good mixing of ferrous oxalate and soil was vital for enhancing the degradation ratio of phenanthrene. After phenanthrene contaminated soil was treated by ferrous oxalate, the toxicity of treated soil was evaluated via the lettuce cultivation experiments. It was demonstrated the toxicity of phenanthrene contaminated soil was significantly reduced by ferrous oxalate according to the growth indexes of lettuces, including root length, leaf length, and fresh weight. This environment-friendly soil remediation method based on ferrous oxalate has huge potential in the remediation of organic pollutant contaminated soil.

This study investigates the effects of water-extracted PM

on a triple-negative breast cancer (TNBC) cell line, MDA-MB-231, by sampling suspended particulates around a building demolition site.

PM

particles were obtained using a high-flow TISCH sampler. Water-soluble PM

were extracted by an ultrasonic oscillator and then freeze-dried. The heavy metal components of soluble PM

was analyzed by ICP-MS. Cell viability was evaluated by MTT assay for cells that were exposed to PM

(200, 400 and 600μg/mL). Wound healing and transwell cell migration and invasion assays were used to measure cell motility and the invasiveness of cancer cells that had been exposed to PM

into a chemo-attractant substance. Interrelated mechanisms of cancer malignancy were analyzed by Western blot analysis.

Nearby PM

concentrations increased significantly during the deconstruction of buildings, and the Cd, Cu, Pb, Zn and Cr contents of soluble PM

also significantly increased. Following exposure to PM

, the survival rate of breast cancer cells was significantly higher than that of the control group. Soluble PM

-treated cells had a higher migration capacity. The signaling pathway of FAK/PI3K/AKT proteins was more activated in PM

-treated cells than the control group. Increased levels of Aurora B and Bcl-2 were associated with cell proliferation. Elevated levels of cathepsins D, β-catenin, N-cadherin, vimentin and MMP-9 were associated with breast cancer cell metastasis.

Soluble PM

from building demolition may promote/progress in surviving TNBC cells, increasing the malignancy of breast cancer. This study offered evidence of a link between demolition PM

and cancer progression.

Soluble PM2.5 from building demolition may promote/progress in surviving TNBC cells, increasing the malignancy of breast cancer. This study offered evidence of a link between demolition PM2.5 and cancer progression.A novel integrated bio-electrochemical system with sulfur autotrophic denitrification (SAD) and electrocoagulation (BESAD-EC) system was established to remove nitrate (NO3--N) and phosphorus from contaminated groundwater. The impacts of a current intensity gradient on the system's performance and microbial community were investigated. The results showed that NO3--N and total phosphorus (TP) could be effectively removed with maximum NO3--N reduction and TP removal efficiencies of 94.2% and 75.8% at current intensities of 200 and 400 mA, respectively. Lower current intensities could improve the removal efficiencies of NO3--N (≤200 mA) and phosphorus (≤400 mA), while higher current intensity (600 mA) caused the inhibition of nutrients removal in the system. MiSeq sequencing analysis revealed that low electrical stimulation improved the diversity and richness of microbial community, while high electrical stimulation reduced their diversity and richness. The relative abundance of some genus involved in denitrification and phosphorus removal processes such as Rhizobium, Hydrogenophaga, Denitratisoma and Gemmobacter, significantly (P less then 0.