Garzadalby2426

Cocaine was more frequent in the areas covered by Copenhagen and Aarhus, whereas heroin/morphine was most frequently detected in the area covered by Odense. Amphetamine was more frequent in the Aarhus area.

Methadone and heroin/morphine still account for most fatal poisonings. However, deaths due to stimulants, especially cocaine, have increased. The abuse pattern has changed and geographical differences have emerged.

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not relevant.After adequate fluid resuscitation in the early stage of septic shock, excessive accumulation of fluid in the body leads to organ dysfunction, which prolongs hospitalization, mechanical ventilation time, and renal replacement therapy time, and is associated with poor prognosis. The fluid de-escalation therapy is an important fluid management strategy performed in the late stage of septic shock. It aims to clear excess fluid by restricting fluid infusion, using diuretics and renal replacement therapy to achieve a negative fluid balance. The fluid de-escalation therapy contributes to improve clinical outcome of septic shock patients and reduce the mortality. This review mainly discusses the current researches and application progress of the fluid de-escalation therapy of abdominal infection-induced septic shock through clarifying its origin, time and endpoint, method of the therapy, the relationship with the control of the source of abdominal infection and its impact on organ function and clinical outcome. Our study intends to provide guidance for the treatment of abdominal infection-induced septic shock in the late stage, and explore the novel research directions.Sepsis is a life-threatening organ dysfunction caused by an imbalance in the response to infection. Clinically the effects of anti-infection and fluid resuscitation are limited, and the morbidity and mortality of sepsis are still high. Interleukin-33 (IL-33), a member of the IL-1 family, binds to various cell types through the ST2-IL-1 receptor helper protein complex. IL-33 and its receptor ST2 play an important role as immune regulatory factors in sepsis. This article reviews the pathophysiological characteristics of sepsis, the biological characteristics of IL-33 and its receptor ST2, and the relationship between IL-33/ST2 and sepsis, so as to provide new ideas for the diagnosis and treatment of sepsis.Tachycardia is an independent risk factor for mortality of patients with sepsis and multiple organ dysfunction syndrome (MODS), and has attracted extensive attention in recent years. Ivabradine, a specific blocker of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel in sinoatrial node, is capable of inducing heart rate reduction (HRR) via binding specific sites of the channel and promotes ventricular filling because of prolongation of the diastolic period. Ivabradine has no negative effect on inotropic contractility, conductivity, and systemic vascular resistance. While Ivabradine has recently shown its beneficial effects in diverse randomized controlled trials on heart failure, this medicine may be a potential option to treat tachycardia in patients with sepsis and septic cardiomyopathy (SCM). Preliminary findings demonstrate that Ivabradine can remarkably lower heart rate and improve hemodynamic stability in patients with sepsis. In addition, Ivabradine has been reported to ameliorate microcirculation perfusion and suppress the inflammatory response. This review discusses the effects of Ivabradine on heart rate control in patients with sepsis and SCM.Pre-hospital first aid can reduce the mortality and morbidity of critically ill patients, and first aid kit plays an important role in pre-hospital first aid. The first aid kit used in clinic is easy to cause the injection to be broken, and it is inconvenient to use at night. Thus, we have designed an "Owl" first aid kit and obtained a national utility model patent (ZL 2018 2 0727656.7) which includes an injection storage cover and a medicine storage box. A number of injection storage plates are arranged on the injection storage cover, which are used for clamping injections of different sizes, etc., and can effectively prevent injection drugs from being extruded, shedding and broken. There is a supporting rod on one side of the injection storage cover, which can improve the efficiency to take medicine from the first aid kit. There are several partitions in the drug storage box, which can be adjusted according to the size and type of articles placed. A number of symmetrical elastic buckles are arranged on the bottom plate for picking up medicine in bottles, which is convenient for emergency personnel to operate with one hand. There is an illuminating lamp at the edge of the injection storage cover, and a number of fluorescent strips are arranged on the inner wall of the medicine storage box. Based on the above device, it is convenient for medical personnel to pick up medicines at night, which can avoid potential errors effectively. The "Owl" first aid kit has a simple structure and low cost. It can prevent the injection from being broken and convenient to operate. At the same time, it is convenient to be used at night, so it is worthy of clinical application.

To explore the clinical characteristics of pneumonia infected by Chlamydophila psittaci (C. psittaci).

A retrospective analysis was performed on 3 cases of C. psittaci pneumonia admitted to People's Hospital of Tongling City from July 2019 to January 2020. The patients' contact history, clinical manifestations, laboratory examination, imaging characteristics and evolution, etiology, treatment process and outcome were analyzed, so as to provide experience for the diagnosis and prevention of C. psittaci pneumonia.

The 3 patients had been infected through pet or zoonotic exposures. All symptoms included high fever (body temperature > 39 centigrade), cough, sputum, chest tightness and dyspnea. click here The disease progressed rapidly, with severe acute respiratory distress syndrome (ARDS) and shock as the main manifestations, but the damages to the heart, liver and kidney were mild. Laboratory tests showed that C-reactive protein (CRP, all > 200 mg/L) and neutrophil proportion (Neut%, > 0.90) were significantly increased, while white blood cell count (WBC) and procalcitonin (PCT) were not significantly increased.