Futtrupkrogh5386

Hyalosira hustedtiana Patrick should revert to its original position in Striatella until the appropriate genus can be determined. We emend Rhabdonematales to encompass Rhabdonemataceae, Grammatophoraceae and Tabellariaceae.

Individuals with lower limb loss are at an increased risk for falls, likely due to impaired balance control. Standing balance is typically explained by double- or single-inverted pendulum models of the hip and/or ankle, neglecting the knee joint. However, recent work suggests knee joint motion contributes toward stabilizing center-of-mass kinematics during standing balance.

To what extent do hip, knee, and ankle joint motions contribute to postural sway in standing among individuals with lower limb loss?

Forty-two individuals (25 m/17f) with unilateral lower limb loss (30 transtibial, 12 transfemoral) stood quietly with eyes open and eyes closed, for 30 s each, while wearing accelerometers on the pelvis, thigh, shank, and foot. Triaxial inertial measurement units were transformed to inertial anterior-posterior components and sway parameters were computed ellipse area, root-mean-square, and jerk. A state-space model with a Kalman filter calculated hip, knee, and ankle joint flexion-extension angles and r for fall risk.

Hip, knee, and ankle motions influence postural sway during standing balance among individuals with lower limb loss. Specifically, increasing intact-side hip flexion, knee extension, and ankle plantarflexion motion increased postural sway. With vision removed, a re-weighting of lower limb joint sensory mechanisms may control postural sway, such that increasing sway may be regulated by proximal coordination strategies and vestibular responses, with implications for fall risk.

To compare treatment outcomes for sinogenic subdural empyema (SE) between those managed with initial endoscopic sinus surgery (ESS) alone versus those treated with a combination of ESS and craniotomy over the last decade at our institution. To better characterize subdural empyema with regard to presentation, causative pathogens, and treatment course.

Retrospective single-center chart review to identify and evaluate pediatric SE patients between 2009 and 2019. Patients meeting inclusion criteria were classified in one of two groups those who initially underwent ESS or frontal trephination without concurrent neurosurgical procedure and those who underwent craniotomy or burr hole in addition to a sinus procedure. Presenting characteristics and treatment outcomes were compared between the two groups.

Eighteen patients met inclusion criteria. The ESS alone and the ESS+craniotomy subgroups each had 9 patients with similar baseline characteristics. The ESS+craniotomy group was more likely to present with neurocoordination with a neurosurgical intervention. There may be a group of patients with SE who may be managed with endoscopic procedures alone and further studies should seek to determine the characteristics of this population.

Surgical SE patients often present to medical professionals in the primary care setting or ED and are managed with outpatient treatment before admission with definitive treatment. In this small retrospective cohort patients who underwent sinus intervention alone had similar rates of return to OR, LOS and adverse neurological outcomes use as those who underwent a sinus procedure in coordination with a neurosurgical intervention. There may be a group of patients with SE who may be managed with endoscopic procedures alone and further studies should seek to determine the characteristics of this population.

The pathophysiology of interstitial lung disease (ILD) impacts body composition, whereby ILD severity is linked to lower lean mass.

To determine i) if pectoralis muscle area (PMA) is a surrogate for whole-body lean mass in ILD, ii) whether PMA is associated with ILD severity, and iii) if the longitudinal change in PMA is associated with pulmonary function and mortality in ILD.

Patients with ILD (n=164) were analyzed retrospectively. PMA was quantified from a chest computed tomography scan. check details Peripheral oxygen saturation (SpO

), 6-min walk distance (6MWD), and pulmonary function were obtained as part of routine clinical care. Dyspnea and quality of life were assessed using the UCSD Shortness of Breath Questionnaire and European Quality of Life 5 Dimensions questionnaire, respectively.

PMA was associated with whole-body lean mass (p<0.001). After adjusting for age, sex, height, body mass, and prednisone status, PMA was associated with %-predicted forced vital capacity (FVC), %-predicted diffusion capacity (DL

), resting and exertional SpO

, and dyspnea (all p<0.05), but not forced expiratory volume in 1s (FEV

), FEV

/FVC, 6MWD, or quality of life (all p>0.05). The annual negative PMA slope was associated with annual negative slopes in FVC, FEV

, and DL

(all p<0.05), but not FEV

/FVC (p=0.46). Annual slope in PMA was associated with all-cause mortality (hazard ratio=-0.80, 95% CI0.889-0.959; p<0.001).

In patients with ILD, PMA is a suitable surrogate for whole-body lean mass. A lower PMA is associated with indices of ILD severity, which supports the notion that ILD progression may involve sarcopenia.

In patients with ILD, PMA is a suitable surrogate for whole-body lean mass. A lower PMA is associated with indices of ILD severity, which supports the notion that ILD progression may involve sarcopenia.Here, we introduce a fully local index named "sensitivity" for each neuron to control chaoticity or gradient globally in a neural network (NN). We also propose a learning method to adjust it named "sensitivity adjustment learning (SAL)". The index is the gradient magnitude of its output with respect to its inputs. By adjusting its time average to 1.0 in each neuron, information transmission in the neuron changes to be moderate without shrinking or expanding for both forward and backward computations. That results in moderate information transmission through a layer of neurons when the weights and inputs are random. Therefore, SAL can control the chaoticity of the network dynamics in a recurrent NN (RNN). It can also solve the vanishing gradient problem in error backpropagation (BP) learning in a deep feedforward NN or an RNN. We demonstrate that when applying SAL to an RNN with small and random initial weights, log-sensitivity, which is the logarithm of RMS (root mean square) sensitivity over all the neurons, is equivalent to the maximum Lyapunov exponent until it reaches 0.0. We also show that SAL works with BP or BPTT (BP through time) to avoid the vanishing gradient problem in a 300-layer NN or an RNN that learns a problem with a lag of 300 steps between the first input and the output. Compared with manually fine-tuning the spectral radius of the weight matrix before learning, SAL's continuous nonlinear learning nature prevents loss of sensitivities during learning, resulting in a significant improvement in learning performance.Consolation is a complex empathic behavior that has recently been observed in some socially living rodents. Despite the growing body of literature suggesting that stress affects some simple form of empathy, the relationship between stress and consolation remains largely understudied. Using monogamous mandarin voles, we found that an acute restraint stress exposure significantly reduced consolation-like behaviors and induced anxiety-like behaviors. Along with these behavioral changes, corticotropin-releasing factor (CRF) and CRF receptor 1 (CRFR1) neurons were activated within the anterior cingulate cortex (ACC) and prelimbic cortex (PrL) but not within the infralimbic cortex (IL). Chemogenetic activation of CRF neurons in the ACC and PrL, recaptured acute stress-induced behavioral dysfunctions. We further observed that intracellular PKA and PKC signaling pathways mediate CRF-induced behavioral dysfunctions, but they work in a regional-specific, sex-biased manner. Together, these results suggest that the local CRF-CRFR1 system within the ACC and PrL is involved in the consolation deficits and anxiety induced by acute stress.Schizophrenia is a severe and multifactorial disorder with an unknown causative pathophysiology. Abnormalities in neurodevelopmental and aging processes have been reported. Relative telomere length (RTL) and DNA methylation age (DMA), well-known biomarkers for estimating biological age, are both commonly altered in patients with schizophrenia compared to healthy controls. However, few studies investigated these aging biomarkers in first-episode psychosis (FEP) and in antipsychotic-naïve patients. To cover the existing gap regarding DMA and RTL in FEP and antipsychotic treatment, we aimed to verify whether those aging markers could be associated with psychosis and treatment response. Thus, we evaluated these measures in the blood of FEP antipsychotic-naïve patients and healthy controls (HC), as well as the response to antipsychotics after 10 weeks of treatment with risperidone. RTL was measured in 392 subjects, being 80 FEP and 312 HC using qPCR, while DMA was analyzed in a subset of 60 HC, 60 FEP patients (antipsychotic-naïve) and 59 FEP-10W (after treatment) using the "Multi-tissue Predictor"and the Infinium HumanMethylation450 BeadChip Kit. We observed diminished DMA and longer RTL in FEP patients before treatment compared to healthy controls, indicating a decelerated aging process in those patients. We found no statistical difference between responder and non-responder patients at baseline for both markers. An increased DMA was observed in patients after 10 weeks of treatment, however, after adjusting for blood cell composition, no significant association remained. Our findings indicate a decelerated aging process in the early phases of the disease.Chlorinated paraffins (CPs) have been widely used as halogenated flame retardants and plasticizers since the mid-20th century. The prevalence of CPs in soil has been widely reported, but the distribution pattern of CPs in urbanized zones and their association with multiple socioeconomic variables have not been adequately explored. Herein, short-chain and medium-chain chlorinated paraffins (SCCPs and MCCPs) were investigated in surface soil samples from Tianjin, China, a typical urbanized area. The concentration distributions of SCCPs and MCCPs showed similar trends in different administrative divisions and land use types urban areas > suburbs > outer suburbs (p agricultural areas (p less then 0.001). The CP congeners in residential surface soils mainly included those with longer carbon chains and high degree of chlorination, while the CP congeners in agricultural surface soils mainly consisted of those with shorter carbon chains and fewer chlorine substituents. Multiple statistical approaches were used to explore the association between socioeconomic factors and CP distribution. CP concentration was significantly correlated to population density and gross domestic product (GDP) (p less then 0.001), and structural equation models incorporating administrative regional planning showed an indirect impact on the distribution of MCCP concentration due to the influence of regional planning on population density. These results highlight the association between CP contamination and the degree of urbanization, and this paper provides useful information toward mitigating the exposure risk of CPs for urban inhabitants.