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The calculated stability constants showed larger differences between the two leaching conditions than between the three MP types with higher log KM values for the UV-irradiated (4.08-5.36) than dark-treated MP-DOM (1.05-3.60). The binding constants were comparable to those of natural organic matter with aquatic/terrestrial origins. The 2D-COS results further revealed that the oxygen-containing structures in MP-DOM generated by UV irradiation might be responsible for the higher binding affinity of the irradiated MP-DOM. This is the first study demonstrating the environmental reactivity of MP-DOM towards metal binding, highlighting the importance of leaching conditions for the metal-binding behavior of MP-DOM.

Sinonasal carcinoma with neuroendocrine differentiation (SCND) is a rare group of tumors with poor prognosis. Treatment and sequence of therapies are still unclear. The goal of this study is to analyze treatment outcomes in SCND using a national database.

The National Cancer Database was queried for SCND from 2004 to 2014. Patient demographics, tumor characteristics and treatment paradigms were tabulated. Multivariable Cox proportional hazards regression was performed for statistical analysis of treatment regimen on overall survival (OS).

A total of 415 patients were identified. Most patients were male (61.2%), with a median age of 58years and the most common primary site was the nasal cavity (52.5%). T4 tumors were observed in 67.7% of cases. Unimodality (41.9%) and bimodality (43.9%) therapies were the most common treatment modalities. Radiation therapy was the only treatment administered in 30% of the patients, while 27.2% received definitive chemoradiation (CRT) and 11.6% had surgery with adjuvant CRT. In our Cox-PH model, age (HR=1.04, p<0.001), T4 (HR=2.6, p=0.004) and N2/N3 (HR=2.18, p=0.001) were associated with worse survival. Trimodality (HR=0.49, p=0.005) and bimodality (HR=0.65, p=0.009) therapies had a better OS compared to unimodality. Patients treated with definitive CRT or surgery with adjuvant CRT had a significant increase in OS (p=0.01 and 0.002 respectively).

SCND appears to be best treated using a multimodality approach with definitive CRT or surgery followed by CRT. Neoadjuvant chemotherapy could be helpful in selecting the best treatment strategy.

SCND appears to be best treated using a multimodality approach with definitive CRT or surgery followed by CRT. Neoadjuvant chemotherapy could be helpful in selecting the best treatment strategy.We explore the use of Fourier series to describe the kinematics of human running. From a database of 285 trials of treadmill running, we drive a musculoskeletal model with 104 anatomical joint angles to obtain kinematics. Using FFT analysis, we determine a fundamental frequency for all independent joint angles and compute average step kinematics. Finally, we represent the average step kinematics using Fourier series with numbers of coefficient pairs ranging from one through ten. We find that five or fewer Fourier coefficient pairs provide an accurate (Pearson's correlation > 0.99 and root mean square difference less then 0.5 degrees) representation for most joint angles. In conclusion, Fourier series appear to provide a compact and valid representation of running kinematics, thus enabling researchers to confidently use Fourier series in research of human running.Characterizing reactive stepping is important to describe the response's effectiveness. Timing of reactive step initiation, execution, and termination have been frequently reported to characterize reactive balance control. However, the test-retest reliabilities of these measures are unknown. Accordingly, the purpose of this study was to determine the between- and within-session test-retest reliabilities of various force plate-derived measures of reactive stepping. Nineteen young, healthy adults responded to 6 small (~8-10% of body weight) and 6 large perturbations (~13-15% of body weight) using an anterior lean-and-release system. Tests were conducted during two visits separated by at least two days. Participants were instructed to recover balance in as few steps as possible. Step onset, foot-off, swing, and restabilization times were extracted from force plates. Nutlin-3 in vitro Relative test-retest reliability was determined through intraclass correlation coefficients (ICCs) and 95% confidence intervals (CIs). Absolute test-retest reliability was assessed using the standard error of the measurement (SEM). Foot-off and swing times had the highest between- and within-session test-retest reliabilities regardless of perturbation size (between-session ICC = 0.898-0.942; within-session ICC = 0.455-0.753). Conversely, step onset and restabilization times had lower ICCs and wider CIs (between-session ICC = 0.495-0.825; within-session ICC = -0.040-0.174). Between-session test-retest reliability was higher (ICC = 0.495-0.942) for all measures than within-session test-retest reliability (ICC = -0.040-0.753). Time to restabilization had the highest SEM, indicating the worst absolute reliability of the measures. These findings suggest multiple baseline sessions are needed for measuring restabilization and step onset times. The minimal detectable changes reported provide an index for measuring meaningful change due to an intervention.Flatfoot is a risk factor for patellofemoral pain syndrome (PFPS), and excessive rearfoot eversion occurring in flatfoot has been associated with the development and progression of PFPS; however, the mechanism remains unclear. This study aimed to investigate transverse shank and frontal rearfoot coordination patterns and variability when running with normal foot and flatfoot. Participants with normal foot (n = 13) and flatfoot (n = 13) were asked to run at their preferred speed. The coupling angle between the shank and rearfoot, representing intersegmental coordination, was calculated using the modified vector coding technique and categorized into four coordination patterns. Standard deviation of the coupling angle was computed as a measure of coordination variability during the stance phase. No differences in the characteristics and spatiotemporal parameters between groups were found, and all participants had rearfoot strike pattern. During midstance, the flatfoot group showed a significantly greater proportion of anti-phase with proximal (shank) dominancy than the normal foot group (p = 0.