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Second, the economic driver is positively correlated with pollution and fluctuates with time. Finally, the technology driver also presents significant spatiotemporal heterogeneity. These spatiotemporal heterogeneities make water pollution control more complicated.Maize (Zea mays) stover, with its natural 13C abundance, was incubated for two years in a gravelly brown earth sandy loam soil that had been under long term cultivation to wheat (Triticum aestivum) for more than 30 years. The relative abundances of 13C in the maize amendment allowed the contributions of the stover to be traced in the components of soil organic matter (SOM) isolated and fractionated using a sequential exhaustive extraction (SEE) process that gave 16 distinct fractions. These were caracterised using elemental, δ13C, FTIR, and 13C NMR analyses. Emphasis is placed on results for two years of incubation but to some extent data are compared with those for similar fractions taken after one year of incubation. Amounts of maize-derived organic carbon in the humic (HA) and fulvic (FA) isolates were more than twice those in the fractions after one year of incubation. The NMR results highlighted compositional differences between the fractions and showed increased contributions of lignin to the HAs and FAs (and especially in the cases of the HAs) as pH increased, and it was evident that humification was taking place after two years of incubation. The most recalcitrant humin fraction, isolated in the final solvent in the sequence, dimethylsulphoxide (DMSO) and sulfuric acid, is composed predominantly of methylene moieties, is compositionally and structurally very different from the humic and hydrophilic isolates, but identical to that which did not dissolve in the solvent. That suggests that exhaustively pre-extracting soil with the NaOH/urea solvent system used will allow a truly representative humin to be obtained using the DMSO/acid solvent system.This paper evaluated the occurrence of hormetic dose responses in pollen reported over the past eight decades. Hormetic doses responses were induced by a wide range of chemical and physical agents in 34 plant species for pollen germination and pollen tube growth/elongation. Agents inducing such hormetic dose/concentration responses in pollen included nutrients, growth-promoting agents, plant and animal hormones, toxic substances, including heavy metals such as cadmium, gaseous pollutants such as ozone, as well as ionizing and non-ionizing radiation. #link# This paper provides further evidence for the broad generality of the hormesis dose response, supporting substantial prior findings that the hormetic response is independent of biological model, inducing agent, and endpoints measured. Given the widespread potential of inducing hormetic dose responses in pollen, these findings indicate the need to explore their emerging biological, ecological, agricultural, economic and public health implications.Urban land cover expansion and human population growth are accelerating worldwide. This is resulting in the loss and degradation of green and blue spaces (e.g. parks, waterways, lakes) in cities, which provide resources to sustain biodiversity and improve human wellbeing. The specific characteristics of these spaces (e.g. sounds, species, safety) that enhance or detract from wellbeing are underexplored, yet this knowledge is needed to inform urban planning, management and policies that will ultimately benefit both people and biodiversity. Research of this kind is rarely conducted in the Global South, where rapid urbanisation threatens biodiversity-rich ecosystems of worldwide significance. Here, we examine how perceptions of green, waterway, and dense urban spaces relate to wellbeing in Georgetown, Guyana. Specifically, we use mediation models to test how perceptions of sound, bird species richness, naturalness, and safety concerns contribute to sites being perceived as restorative which, subsequently, influedesign and management plans that could deliver multiple co-benefits, particularly in biodiversity-rich cities in neotropical regions.Exposure to silica nanoparticles (SiNPs) has been suggested to cause physical disorders, yet the effects of SiNPs on female reproduction have not been illustrated. This study was implemented to explore the reproductive toxicity of SiNPs on female and reveal its underlying mechanisms. Methodologically, the fluorescein isothiocyanate (FITC)-SiNPs were synthesized by coupling with FITC and then used to track the biodistribution of SiNPs in vitro and in vivo. In total, 30 mice were intratracheally injected 0.25 g of FITC-SiNPs, and 6 mice injected with the same volume of saline were used as controls. The results showed that SiNPs penetrated the cellular membrane, triggering apoptosis and inhibiting proliferation, tube formation, and invasion of trophoblast. Mechanistically, SiNPs was demonstrated to dysregulate Fbp2, Cpt1a, Scd1, and Pfkl, and further induced accumulation of pyruvate and fatty acid in mitochondria through the AMPK signaling pathway, which finally activated the Caspase-3-dependent apoptosis. Consistently, the similar alterations of these genes were detected in vivo, and the uterine inflammatory infiltration aggravated with the extension of the observation duration. These results suggested that SiNPs induced trophoblast apoptosis and uterine inflammation, and ultimately caused acute reproductive toxicity on female. The underlying mechanism might be explained by the dysregulation of Fbp2/Cpt1a/Pfkl/Scd1 axis, which promoted the overload of glucose and lipid through the AMPK signaling pathway. These findings were of great significance to guide a comprehensive understanding of the reproductive toxicity of SiNPs as well as the development of environmental standards.Decline in snow mass threatens the regional economy that critically depends on meltwater. However, the economic scale of snow mass loss is hardly understood, and its role in the vulnerability of future economic development is unclear. Reparixin CXCR inhibitor investigate the current reserves of snow cover and the value of its loss. The result showed that the total annual snow mass in western China declines at a rate of 3.3 × 109 Pg per decade (p less then 0.05), which accounts for approximately 0.46% of the mean of annual snow mass (7.2 × 1011 Pg). Snow mass loss over the past 40 years in western China turns into an average loss value of CN¥0.1 billion (in the present value) every year ($1 = CN¥7). If the trend continues at the current rate, the accumulated loss value would rise to CN¥63 billion by 2040. Furthermore, subject to the combinations of RCPs and SSPs scenario, the future economic value of snow mass loss in western China appears to accelerate driven by both declining snowmelt resources and socioeconomic development demand.