Fuentesrandolph0284

It is unclear whether angiotensin-converting enzyme inhibitors (ACEIs) in combination with angiotensin II receptor blockers (ARBs) are superior to ACEIs or ARBs alone in the treatment of nondiabetic chronic kidney disease (CKD). The present meta-analysis was designed to assess the efficacy and safety of ACEIs in combination with ARBs in nondiabetic CKD.

The PubMed, Embase, and Cochrane Library databases were searched to identify randomized controlled trials (RCTs) published prior to March 2020. A random-effects model was used to calculate the effect sizes of eligible studies.

The present meta-analysis of 20 RCTs encompassing 1,398 patients with nondiabetic CKD demonstrated that ACEIs in combination with ARBs were superior to ACEIs or ARBs alone in reducing urine albumin excretion (SMD, -0.69; 95% CI, -1.13 to -0.25; P=0.002), urine protein excretion (SMD, -0.34; 95% CI, -0.46 to -0.23; P<0.001) and blood pressure (systolic blood pressure WMD, -1.43; 95% CI, -2.42 to -0.44; P=0.005; diastolic blood pressure WMD, -1.85; 95% CI, -2.67 to -1.04; P<0.001) without decreased glomerular filtration rate (SMD, -0.07; 95% CI, -0.20 to 0.06; P=0.30) or increased incidences of hyperkalaemia (RR, 1.25; 95% CI, 0.47 to RR=0.80; P=0.20 to 0.06; P=0.30).

Compared with ACEIs or ARBs alone, ACEIs in combination with ARBs are effective and safe in the treatment of nondiabetic CKD. ACEIs combined with ARBs may be a better choice to reduce proteinuria as long as it can be tolerated. (PROSPERO number CRD42020179398).

Compared with ACEIs or ARBs alone, ACEIs in combination with ARBs are effective and safe in the treatment of nondiabetic CKD. ACEIs combined with ARBs may be a better choice to reduce proteinuria as long as it can be tolerated. (PROSPERO number CRD42020179398).The recent pandemic due to SARS-CoV-2, the last isolated human beta-coronavirus, has revolutionized modern knowledge of the pathogenesis of viral pneumonia. The lack of specific antiviral drugs and the need to develop adequate research for new antiviral drugs capable of treating this new form of the disease undertook three different research paths quickly. The first one is aimed to test antiviral molecules already present in therapeutic use, with a mechanism of an action directed towards viral proteins functional to replication or adsorption; the second one, it is the repositioning of molecules with known pharmacological activity for which various chemistry studies have been prepared in an attempt to find new and specific viral targets; the third, it is the search for molecules of natural origin for which to demonstrate a specific anti-coronavirus activity. Many databases of natural and synthetic substances have been used for the identification of potent inhibitors of various viral targets. The field of computer-aided drug design seems to be promising and useful for the identification of SARS-CoV-2 inhibitors; hence, different structure- and ligand-based computational approaches have been used for their identification. This review analyzes in-depth and critically the most recent publications in the field of applied computational chemistry to find out molecules of natural origin with potent antiviral activity. Furthermore, a critical and functional selection of some molecules with the best hypothetical anti-SARS-CoV-2 activity is made for further studies by biological tests.

Abdominal aortic aneurysms (AAAs) is an important cause of death in older adults due to aortic rupture. There are currently no effective medical therapies for AAA, with surgery being the only acceptable treatment. There is frequently an extended period between AAA diagnosis and treatment by corrective surgery, during which an effective drug therapy could prevent or delay the need for AAA repair.

The aim of this review was to critically summarize prior research investigating the potential benefits of phytochemicals in preventing or treating AAA.

In vitro, in vivo and human studies examining the effect of phytochemicals in AAA models and patients were critically summarised.

Some preliminary data support the further investigation of curcumin, radix astragali, grape seed polyphenols, resveratrol, Ginkgo biloba extract (EGb 761), Ginsenoside Rb1, Dan Hong, Epigallocatechin-3-gallate, Baicalein, Fucoidan, Quercetin and Salvianolic acid as potential treatments for AAA.

Experimental in vivo and in vitro studies suggest the potential benefits of a number of medicinal herbs and phytochemicals in preventing or reducing the progression of AAA. In order to assess whether these findings can be translated into proven treatments, will require adequately designed double-blind randomized clinical trials.

Experimental in vivo and in vitro studies suggest the potential benefits of a number of medicinal herbs and phytochemicals in preventing or reducing the progression of AAA. In order to assess whether these findings can be translated into proven treatments, will require adequately designed double-blind randomized clinical trials.Previous studies have concentrated on the value of managerial leadership for safety behavior conduct by employees in the workplace. However, safety leadership styles concerning mindful safety practices have rarely been examined. The goal of this study is therefore to investigate the relationships between safety-specific leaderships (transformational and active transactional leadership) and the adoption of mindful safety practices among first-line workers mediated by safety climate in the Chinese petroleum industry. Data were obtained from first-line workers in two Chinese petroleum companies. PLS-SEM results show that transformational and active transactional leadership are positively related to safety climate, which in turn affects mindful safety practice adoption in the Chinese petroleum industry. The results of the current study indicate that transformational and active transactional leadership in a safety-specific view offer a comprehensive leadership model for mindful safety practices conduct in the Chinese petroleum industry.Ozone (O3) is a prevalent air pollutant causing lung inflammation. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxysterols, such as secosterol-A (SecoA), which are electrophiles capable of forming covalent linkages preferentially with lysine residues and consequently modify protein function. The breadth of proteins modified by this oxysterol as well as the biological consequences in the lung are unknown. Using an alkynyl-tagged form of SecoA and shotgun proteomics, we identified 135 proteins to be modified bronchial epithelial cells. PI3K inhibitor Among them was NLR Family Pyrin Domain Containing 2 (NLRP2) forming a SecoA-protein adduct at lysine (K1019) in the terminal leucine-rich-repeat, a known regulatory region for NLR proteins. NLRP2 expression in airway epithelial cells was characterized and CRISPR-Cas9 knockout and shRNA knockdown of NLRP2 was used to determine its function in O3-induced inflammation. No evidence for NLPR2 inflammasome formation or NLRP2-dependent increase in caspase-1 activity in response to O3 was observed.