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Objectives To assess the clinical significance and single-photon emission computed tomography/computed tomography (SPECT/CT) features of atraumatic costal cartilage fracture (CCF) in patients with malignant tumors. Methods This was a retrospective review of 38 tumor patients with atraumatic CCF referred to SPECT/CT, who were served as the study group (SG). The features of SPECT/CT of atraumatic CCF were assessed. Another 100 tumor patients who underwent chest SPECT/CT and did not have CCF were randomly selected as the control group (CG). In all patients (SG + CG), the diagnostic powers in the detection of atraumatic CCF were computed among CT, SPECT, and SPECT/CT. The final diagnosis was based on pathological findings and radiologic follow-up of at least 1 year. Results On SPECT/CT images of atraumatic CCF in the SG, fracture lines, irregular calcification, deformation, and swelling were, respectively, noted in 26.3, 47.4, 34.2, and 18.4% of lesions; low, moderate, and high uptake were, respectively, noted in 13.2, 52.6, and 34.2% of lesions. In all patients (SG + CG), the diagnostic powers in the detection of atraumatic CCF of CT, SPECT, and SPECT/CT were as follows sensitivity 63.2, 100.0, and 92.1%; specificity 86.0, 81.0, and 94.0%; negative predictive value 86.0, 100.0, and 96.9%; positive predictive value 63.1, 66.7, and 85.4%; and area under the curve value 0.746, 0.905, and 0.931. Conclusions Atraumatic CCF has certain characteristic appearances on SPECT/CT. It should be enrolled in the differential diagnoses when costal cartilages of patients with malignant tumors show abnormal elevated 99mTc-MDP uptake on scintigraphy. Single-photon emission computed tomography/CT has excellent diagnostic power in detecting atraumatic CCF. Copyright © 2020 Li, Zhang, Li and Zhang.Cells and extracellular matrix (ECM) components represent the multifaceted and dynamic environment that distinguishes each organ. Myricetin Cancer is characterized by the dysregulation of the composition and structure of the tissues, giving rise to the tumor milieu. In this review, we focus on the microenvironmental analysis of colorectal cancer (CRC) and rhabdomyosarcoma (RMS), two different solid tumors. While a lot is known about CRC environment, for RMS, this aspect is mostly unexplored. Following the example of the more complete CRC microenvironmental characterization, we collected and organized data on RMS for a better awareness of how tissue remodeling affects disease progression. Copyright © 2020 Saggioro, D'Angelo, Bisogno, Agostini and Pozzobon.Background Professional Self-Concept (PSC) affects one's way of thinking, role evolution, professional behavior, and performance. The present study aimed to determine the effect of Pilates exercises on PSC in nurses working in Intensive Care Units (ICU) and emergency departments. Materials and Methods This quantitative study was a randomized controlled field trial. The study population consisted of all nurses working in ICUs and emergency departments from 2016 to 2017. Based on the inclusion and exclusion criteria, 110 nurses were assigned to intervention and control groups using a permuted block randomization method. The Nurses' Self-Concept Questionnaire (NSCQ) was completed by both groups. The intervention group performed Pilates 30 min each session at home for 8 weeks. The Chi-squared test, Mann-Whitney U, Kruskal-Wallis test, and t-test were employed to analyze the collected data. Results Mean and standard deviation of the PSC score was 223.73 (23.35) in the intervention group and 215.75 (34.54) in the control group at baseline; it reached 229.17 (23.36) in the intervention group and 217.77 (34.44) in the control group at the end of the study. The difference was not significant. The paired-samples t-test showed that the score of PSC was increased by 5.45 points on average in the intervention group after the Pilates exercises, which was statistically significant (t54= 25.80, p less then 0.001). Conclusions Pilates enhances the score of PSC in nurses working in ICUs and emergency departments. The designing and implementation of these easy and safe exercises may prove beneficial for nurses. Copyright © 2020 Iranian Journal of Nursing and Midwifery Research.Background To provide excellent nursing care services, nursing standards should be considered; one of these standards is being socially responsible. Regarding the lack of appropriate instruments in Iran for measuring social responsibility, the design of an instrument in accordance with Iranian culture seems to be necessary. So, the present study aimed to design a valid and reliable tool for measuring the social responsibility of nurses. Materials and Methods In this sequential exploratory mixed-method study, designing and psychometric evaluation of nurses' social responsibility instrument were performed in qualitative and quantitative phases. In the qualitative phase, the concept of nurses' social responsibility was explored and its characteristics and dimensions were identified using a hybrid concept analysis model. In the quantitative phase, validity (face, content, and construct), and reliability (Cronbach's α and interclass correlation) were examined a sample of nurses in Tehran, Iran (n = 280). The construct validity of the scale was determined using exploratory factor analysis. Results The findings supported 23 items in four factors dedicated to others, efforts to improve social conditions, holistic vision, and favorable relationship. A total of 44.40% of the variance was explained by these four factors. Scale-Content Validity Index/Average (S-CVI/AVE) was calculated 0.91 and it was found that the Cronbach's alpha was 0.88. Conclusions The researchers focused on designing and psychometric evaluation of nursing social responsibility tools based on nurses' opinions and prepared a native, valid, and reliable tool, which seems to be a good tool for measuring the social responsibility of nurses. Copyright © 2020 Iranian Journal of Nursing and Midwifery Research.Background Social support perceived by the elderly can reduce mental health problems including depression. In Iranian society, some elderly people spend their elderly years in senior day care centers established to promote social protection for the elderly. Therefore, the purpose of this study was to assess perceived social support and depression in the elderly members of senior day care centers and compare the results with that of elderly individuals living at nursing homes and at home. Materials and Methods This descriptive, cross-sectional study was conducted on 315 elderly people. The participants were selected using stratified random sampling method and a random number table. The data collection tools used consisted of a demographic characteristics questionnaire, the Barthel index for assessing Activities of Daily Living (ADL), Social Support Appraisals (SSS-As) scale, and Geriatric Depression Scale short form (GDS-15). ANOVA, Chi-square, the Pearson correlation coefficient, and linear regression analysis were used to examine the hypotheses.