Friedmanwelsh7954

Aim Gliclazide (G) is a drug prescribed for Type 2 diabetics, although recent studies suggest it has desirable effects in both types of diabetes, Type 1 diabetes and Type 2 diabetes. G has an inconsistent absorption due to poor formulation and bile acids (BAs) have shown significant promise in drug formulation optimization. Hence, the study aimed to examine G effects on histopathological, anti-inflammatory and antidiabetic effects when encapsulated with BAs. Materials & methods Rats were randomized into eight groups, of which seven were made Type 1 diabetes and treated with various BA-based treatments. Valproate Tissue histopathology, inflammation and the bile acid profile were analyzed. Results & conclusion G capsules showed no histological but the most anti-inflammatory effects, which suggest significant beneficial effects in diabetes treatment.We hypothesized that exposure to weight stigma simultaneously increases motivation to lose or avoid gaining weight to avoid future stigma and decreases perceived capacity to do so, by heightening concerns about experiencing stigma and negative affect. Study 1 showed that more frequently experiencing weight-based discrimination was associated with greater concerns about being a victim of weight stigma, which predicted increased motivation to lose weight but decreased perceived capacity for weight control. Study 2 showed that participants randomly assigned to view a weight-stigmatizing (vs. control) message showed increased concerns about being a target of weight stigma, which indirectly increased motivation to lose weight and decreased state self-control. These, in turn, predicted increased willingness to engage in unhealthy weight-loss behaviors and decreased perceived capacity for weight control, respectively. Study 3 showed that increased motivation to avoid stigma and increased negative affect mediate these effects of exposure to weight stigma.In legal proceedings, when no corroboration is possible with external sources of evidence, judges and jurors derive from their own experience the criteria to ascertain if a memory report is accurate and a witness credible. These legal criteria closely resemble the aspects traditionally investigated by literature on Flashbulb memory (i.e., consistency, confidence, quantity), but have failed to obtain a generalised consensus within the scientific community. Drawing up a set of univocal rules upon which to base a conclusion regarding witnesses' credibility is a difficult task, from both legal and scientific points of view. Respectful cooperation between cognitive science and criminal law will encompass both technical support by expert witnesses, and updating guidelines for fact-finders. This cooperation would prevent the risk of common sense fallacies in the legal process, preserving the legal autonomy to evaluate witness credibility.Despite efforts on some college campuses to address the issue of sexual victimization, the numbers have not changed much over the last four decades. The purpose of this study is to examine how demographic, contextual, and behavioral factors influence sexual victimization on college campuses. Using data from the Fall 2011 National College Health Assessment/American College Health Association survey, we examine three hypotheses (1) contextual factors will have a greater effect on the likelihood of victimization than behavioral factors; (2) demographic factors will have a greater effect on the likelihood of victimization than behavioral factors; and (3) contextual factors for men will have a greater effect than contextual factors for women. While previous studies have tackled portions of these larger objectives, few studies have focused on all three sets of factors of analysis simultaneously. Overall, we find that behavioral factors predict sexual victimization better than either demographic or contextual factors for both men and women. However, we also find that some contextual factors are significant, including variables not generally discussed in the literature, such as perception of typical student behaviors and dissemination of violence prevention programming and information. In addition, we add to the literature by showing how demographic, behavioral, and contextual factors of sexual victimization vary in significance for men and women. These findings support the calls for more sexual violence prevention programming on college campuses that is more intersectional and addresses the issue of sexual violence based on the knowledge we have gained about individual, interactional, and institutional factors that contribute to this problem.Transgender and nonbinary (TNB) individuals experience high rates of myriad types of victimization, including in health care settings. Many TNB people avoid medical visits for fear of mistreatment and, when they do visit a provider, report negative experiences (e.g., denial of services, misgendering, verbal abuse). These negative experiences are heightened for TNB individuals who have an intersecting marginalized identity (e.g., low socioeconomic status, disability). Using data from the 2015 United States Transgender Survey, the largest survey of TNB individuals in the United States to date, the present study examines differential experiences of victimization in health care settings by TNB identity and other demographics (i.e., race, age, class, educational level, disability). A series of multivariate logistic regressions were run to determine adjusted odds ratios (AORs) for TNB individuals recently (i.e., in the past year) experiencing four forms of victimization (a) doctor/health care provider used harsh ort behavior toward TNB patients, as well as intersectional research to better ascertain the extent and nuance of victimization within TNB health care.AIM To evaluate social-emotional development and adaptive behavioral outcomes in a cohort of extremely low birth weight infants with a confirmed diagnosis of neonatal seizures. METHODS This is a retrospective cohort study of preterm infants weighing ≤1000 g at birth, with a diagnosis of neonatal seizures, evaluated between 21 and 31 months of age using the Bayley Scales of Infant Development (Bayley-III) in a longitudinal neurodevelopmental follow-up program. Seizures were diagnosed using continuous video electroencephalography interpreted by a pediatric neurologist. RESULTS Nineteen infants meeting criteria were included and were matched with 38 control subjects, without clinical signs of seizures, and similar baseline characteristics. Multivariate analysis revealed significantly lower social-emotional development (-14.8 points; P = .05) and adaptive behavior scores (-10.8 points; P less then .01) on the Bayley III in children with seizures compared to controls without clinical signs of seizure. INTERPRETATION Seizures are associated with impaired adaptive behavior and social-emotional development in this cohort of extremely low birth weight infants.