Freemanhendriksen3621

Instead, similar to other forms of temporal information, temporal orientation might be determined from such contents by reconstructive post-retrieval processes. These results have implications for how the human ability to 'mentally travel' in time is cognitively implemented.Sense of agency refers to the experience that one's self-generated action causes an event in the external environment. Here, we review the behavioural and brain evidence of aberrant experiences of agency in movement disorders, clinical conditions characterized by either a paucity or an excess of movements unrelated to the patient's intention. We show that specific abnormal agency experiences characterize several movement disorders. Those manifestations are typically associated with structural and functional brain abnormalities. However, the evidence is sometimes conflicting, especially when considering results obtained through different agency measures. The present review aims to create order in the existing literature on sense of agency investigations in movement disorders and to provide a coherent overview framed within current neurocognitive models of motor awareness.Thecadinium is a morphologically heterogenous marine benthic genus. Its polyphyly has been discussed. After redefinition of the sensu stricto genus, sensu lato taxa now need reclassification. Heterotrophic, morphologically closely related species were studied in detail. Molecular phylogenetic data for three of the four known species (T. ornatum, T. acanthium, T. ovatum) and new morphological data were obtained, leading to an emended thecal plate pattern, including the presence of an apical pore complex and an additional hypothecal plate. The results confirm the close relationship of the species and justify the description of Carinadinium gen. nov., characterized by the tabulation APC 3/4' 1/0a 6″ 6c 5s 5‴ 2'‴, an epithecal plate of special morphology, an apical flange, a ventral pore, antapical appendages, a descending cingulum and lateral cell flattening. The genus can be separated into two sub-clades, one with a third precingular 'dimple'-plate, four apical and no anterior intercalary plates and the other with a 'multi-pimple'-plate as third precingular or its homolog plate, three apical and one anterior intercalary plate. Carinadinium is phylogenetically related to the planktonic genera Protoceratium, Pentaplacodinium, and Ceratocorys (family Protoceratiaceae), and clearly belongs into the order Gonyaulacales, but with uncertain family affiliation.

Behavior problems are highly prevalent in young maltreated children. Their etiology is multifactorial and has been widely documented. Lately, researchers paid increased attention to the role of sleep in non-maltreated children's behavior problems. They showed that poor sleep (e.g., short sleep duration, nocturnal awakenings) increased behavior problems. In addition, an inadequate sleep ecology (e.g., lack of sleep hygiene or bedtime routine) may lead to sleep problems.

As maltreated children often live in disorganized environments, this study aims to map knowledge about sleep ecology and sleep characteristics, as well as their associations with behavior problems in young maltreated children from one to five years old.

A scoping review was performed according to the PRISMA-SR checklist. Bibliographic databases were searched from 1993 to May 2020.

From the 650 studies screened, nine reported results about sleep ecology or sleep characteristics or their associations with behavior problems in young maltre young maltreated children is scarce. Their sleep ecology especially deserves to be investigated. Longitudinal studies, studies with comparison groups, combining objective and subjective validated sleep measures, and taking into account maltreatment characteristics and children's developmental stage should be pursued.

The reunification of children in out-of-home care has gained increasing attention from both researchers and policy makers in many jurisdictions in recent years. In Ireland, however, reunification has received little attention and there is a dearth of data, research, policy and guidance in this area.

This paper explores perspectives on, and experiences of, reunification in Ireland among respondents from a range of professional and practice backgrounds. The authors suggest that there are lessons to be learned from the Irish case for other jurisdictions with limited policy and research in the area of reunification.

The research was carried out using a qualitative approach. Semi-structured interviews were carried out with 12 respondents from a range of professional and practice backgrounds and/or experience of reunification in Ireland.

Findings suggest that there is a lack of clarity and a limited focus on the process of reunification for children in care in Ireland. This lack of focus on reunification and absence of national guidance appears to have resulted in some children 'drifting' through the care system with little exploration of the possibility to return home. Minimal emphasis on working with birth parents to support and enable them to resume caring for their children is reported.

Findings suggest that future efforts in this area should focus on 1) developing a comprehensive research agenda in relation to reunification; 2) ensuring reunification is clearly placed on the policy agenda in Ireland; and 3) establishing a framework for practice guidance and a specialised reunification service to promote working with birth parents.

Findings suggest that future efforts in this area should focus on 1) developing a comprehensive research agenda in relation to reunification; 2) ensuring reunification is clearly placed on the policy agenda in Ireland; and 3) establishing a framework for practice guidance and a specialised reunification service to promote working with birth parents.

To determine which surgical factors are associated with quality-of-life (QOL) outcomes in oral cavity cancer survivors after free flap reconstruction of the oral cavity.

A cross-sectional study was conducted from a multidisciplinary head and neck cancer (HNC) survivorship clinic. Oral cavity cancer survivors with at least 6-months of postoperative follow-up from ablation and free flap reconstruction were included. Primary outcome measures were validated patient-reported outcome measures (PROMs) including the Eating Assessment Tool-10 (EAT-10) measure of swallowing-specific QOL, University of Washington Quality of Life (UW-QOL) physical and social-emotional subscale scores and feeding tube dependence.

Extent of tongue resection was associated with EAT-10 and the UW-QOL Physical subscale scores. Patients with oral tongue defects reported worse scores than with composite defects in the EAT-10 and UW-QOL physical domain (p=0.0004, 0.0025, respectively). This association no longer applies when controlling foht the need to address QOL in a multidisciplinary fashion post-operatively.Glucocorticoid treatment is the standard initial therapy for patients with immune thrombocytopenia (ITP). Despite a rate of 60-80% of initial remissions, only 30 to 50% of adults have a sustained response after discontinuation. Second line options are splenectomy, thrombopoietin-receptor agonists (TPO-RAs), rituximab and intravenous immunoglobulin. Third line treatments include a mix of immunosuppressive drugs (e.g. azathioprine, ciclosporin, etc.). Recently international guidelines have proposed a treatment algorithm formalizing TPO-RAs and splenectomy as second and third line respectively, confirming splenectomy as second line choice only in emergency. Here we present a single center observational retrospective study of eltrombopag as second line treatment. We evaluated 48 adult primary chronic ITP patients since 2003. Forty-four out of 48 patients received a first line treatment with glucocorticoids. DNA Repair inhibitor Twenty-two (61%) patients needed a second line treatment 18 received eltrombopag, 3 a second course of steras second line treatment in chronic ITP patients.Kirsten rat sarcoma viral oncogene homolog (KRAS) is a proto-oncogene of the RAS-MAPK pathway. KRAS mutations are present in a variety of malignancies including lung, colorectal, and pancreatic cancer. Until the recent approval of sotorasib, a KRAS G12C inhibitor, lack of targeted therapy for KRAS has resulted in poor prognosis of patients with tumors harboring KRAS mutations. While the conditional approval of sotorasib was a major breakthrough for those patients harboring KRAS G12C mutations, G12C only accounts for a fraction of those with KRAS mutations and eventual resistance to G12C inhibitors are unavoidable. This comprehensive review on KRAS inhibitors covers accumulating evidence on not only the G12C inhibitors but also other therapeutic attempts to tackle KRAS including combination therapy as well as direct inhibition with vaccines, adoptive T cell therapy, proteolysis-targeted chimeras (PROTACs) and CRISPR/Cas9.The mangrove is an ecosystem bounded by the line of the largest tide in size that occurs in climatic and subtropical regions. In this environment, microorganisms and their enzymes are involved in a series of transformations and nutrient cycling. To evaluate the biotechnological potential of fungi from a mangrove ecosystem, samples from mangrove trees were collected at the Paranaguá Estuarine Complex in Brazil and 40 fungal isolates were obtained, cultivated, and screened for hydrolytic and ligninolytic enzymes production, adaptation to salinity and genetic diversity. The results showed a predominance of hydrolytic enzymes and fungal tolerance to ≤ 50 g L-1 sodium chloride (NaCl) concentration, a sign of adaptive halophilia. Through morphological and molecular analyses, the isolates were identified as Trichoderma atroveride, Microsphaeropsis arundinis, Epicoccum sp., Trichoderma sp., Gliocladium sp., Geotrichum sp. and Cryphonectria sp. The ligninolytic enzymatic potential of the fungi was evaluated in liquid cultures in the presence and absence of seawater and the highest activity of laccase among isolates was observed in the presence of seawater with M. arundinis (LB07), which produced 1,037 U L-1. Enzymatic extracts of M. arundinis fixed at 100 U L-1 of laccase partially decolorized a real textile effluent in a reaction without pH adjustment and chemical mediators. Considering that mangrove fungi are still few explored, the results bring an important contribution to the knowledge about these microorganisms, as their ability to adapt to saline conditions, biodegradation of pollutants, and enzymatic potential, which make them promising candidates in biotechnological processes.Given their remarkable beneficial effects on plant growth, several Azospirillum isolates currently integrate the formulations of various commercial inoculants. Our research group isolated a new strain, Azospirillum sp. UENF-412522, from passion fruit rhizoplane. This isolate uses carbon sources that are partially distinct from closely-related Azospirillum isolates. Scanning electron microscopy analysis and population counts demonstrate the ability of Azospirillum sp. UENF-412522 to colonize the surface of passion fruit roots. In vitro assays demonstrate the ability of Azospirillum sp. UENF-412522 to fix atmospheric nitrogen, to solubilize phosphate and to produce indole-acetic acid. Passion fruit plantlets inoculated with Azospirillum sp. UENF-41255 showed increased shoot and root fresh matter by 13,8% and 88,6% respectively, as well as root dry matter by 61,4%, further highlighting its biotechnological potential for agriculture. We sequenced the genome of Azospirillum sp. UENF-412522 to investigate the genetic basis of its plant-growth promotion properties.