Freemanbeck4076

This chapter outlines recent advances in imaging of disorders of the cervicocerebral vasculature that permit evaluation of the lumen, the vessel wall, and the patterns of blood flow within the vessel. Noninvasive MR techniques to evaluate the vessel lumen, such as noncontrast time-of-flight magnetic resonance angiography and contrast-enhanced magnetic resonance angiography (CEMRA) are routinely used in diagnosis, planning, and posttreatment follow-up. More recently, high-resolution vessel wall imaging MRI (VWMRI) has been developed, which provides additional information about the vessel wall or aneurysm wall. VWMRI wall signal and enhancement patterns may permit differentiation between vasculopathies and between stable and unstable unruptured aneurysms. In addition, the study of blood flow patterns using phase-contrast MRI (4D flow MRI) and image-based computational fluid dynamics has been used to characterize flow and wall shear stress within aneurysms, flow within arteriovenous malformations (AVMs) and pulsatile tinnitus. Digital subtraction angiography (DSA), however, remains the gold standard in the evaluation and treatment of neurovascular diseases. New adjunctive DSA techniques, such as 4D-DSA reconstruction and color flow analysis, are also covered. These new MRI and DSA techniques increase diagnostic accuracy, improve understanding of the pathophysiology and natural history of neurovascular disease, inform and guide treatment, and may provide risk stratification for patients being considered for therapy.The neurological intensive care unit plays an integral role in the management of cerebrovascular disease in the acute and perioperative period. Understanding the use of intracranial pressure (ICP) monitoring and how to apply the appropriate intervention for ICP elevation to ensure adequate cerebral perfusion is the foundation of neurocritical care. Careful management of the interplay between cerebral and systemic physiology, particularly in disorders of cerebral autoregulation, is critical in preventing secondary brain injury. Finally, understanding the cerebral pathophysiology of the underlying injured brain in acute stroke, subarachnoid hemorrhage, and arterial stenosis can help to guide the optimal use of interventional endovascular procedures in these disease states.The complex development of the brain vascular system can be broken down by embryonic stages and anatomic locations, which are tightly regulated by different factors and pathways in time and spatially. The adult brain is relatively quiescent in angiogenesis. However, under disease conditions, such as trauma, stroke, or tumor, angiogenesis can be activated in the adult brain. Disruption of any of the factors or pathways may lead to malformed vessel development. In this chapter, we will discuss factors and pathways involved in normal brain vasculogenesis and vascular maturation, and the pathogenesis of several brain vascular malformations.In order to reduce intrahospital times for stroke patients, we have implemented various strategies throughout the last 4 years. Swift restoration of cerebral perfusion is essential for the outcomes of patients with acute ischemic stroke. Endovascular treatment (EVT) has become the standard of care to accomplish this in patients with acute stroke due to large vessel occlusion (LVO). JDQ443 datasheet To achieve reperfusion of ischemic brain regions as fast as possible, all in-hospital time delays have to be avoided. Therefore management of patients with acute ischemic stroke was optimized with an interdisciplinary standard operating procedure (SOP). Stroke neurologists, diagnostic as well as interventional neuroradiologists, and anesthesiologists streamlined all necessary processes from patient admission and diagnosis to EVT of eligible patients. In a second step we established a one-stop management of stroke patients, meaning that imaging was acquired with the same angiography suite use for treatment of patients with LVO. In the last section of this chapter we discuss the latest trials on stroke therapy and their implications for our current triage systems and imaging patterns.There has been increasing adoption of endovascular stroke treatment in the United States following multiple clinical trials demonstrating superior efficacy. Next steps in enhancing this treatment include an analysis and development of stroke systems of care geared toward efficient delivery of endovascular and comprehensive stroke care. The chapter presents epidemiological data and an overview of the current state of stroke delivery and potential improvements for the future in the light of clinical data.Complications are an unfortunate reality in the field of interventional neuroradiology. While complications cannot be eliminated entirely, their occurrence and severity can be mitigated by the competency achieved through training, knowledge of cerebrovascular anatomy and pathology, and well-conceived and executed plans crafted in conjunction with a multidisciplinary team. Frequent communication among the team throughout the entire process of care is vital. In the ensuing chapter, an overview is provided of the most common complication types-nontarget embolization and hemorrhage-followed by practical considerations for their management. Finally, the chapter concludes with a brief consideration of the emotional management for the patient, their loved ones, and the involved practitioners.Vertebral augmentation, including vertebroplasty and kyphoplasty, is a minimally invasive, image-guided procedure in which cement (typically polymethylmethacrylate (PMMA)) is injected into a vertebral body to treat painful fractures. The majority of vertebroplasty and kyphoplasty procedures are performed to treat symptomatic osteoporotic compression fractures refractory to conservative medical therapy; however, there is also evidence to suggest the benefits of augmentation in patients with refractory pain in the acute compression setting. The primary goal of augmentation is decreasing pain and improving a patient's functional status. The secondary goal of augmentation is vertebral body stabilization. This chapter outlines the indications, contraindications, techniques, and literature behind vertebral augmentation.