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To assess the level of deterioration in functioning of ED patients during confinement, due to COVID-19, and examine potential contributing factors (coping strategies, anxiety-depressive symptomatology and personality traits).

A total of 74 ED patients in treatment before the COVID-19 outbreak, contributed to this study. Baseline pre-treatment evaluation included the SCL-90R, TCI-R, EDI-2 and Y-FAS 2.0 questionnaires for general psychopathology, personality and ED severity indexes. ED symptoms, coping strategies, socio-demographic data and COVID-19 concerns were collected by clinicians through a semi-structured telephone survey during lockdown.

A deterioration in ED symptoms and general psychopathology (anxiety and depression), during lockdown, was associated with low self-directedness. Higher ED symptomatology during confinement was associated with less-adaptive coping strategies to deal with lockdown situation leading to an increase in weight.

These specific vulnerability factors to further confinement or stressful situations may help design personalized preventive and therapeutic approaches.

These specific vulnerability factors to further confinement or stressful situations may help design personalized preventive and therapeutic approaches.

Concerns exist about the survival and complication rates of highly constrained total knee arthroplasty (TKA) prostheses. The aims of this study were to determine if there were differences between the revision and complication rates of fully stabilized (FSTKA) and hinged (HTKA) TKA, when used in both primary and revision procedures.

Survivorship of all highly constrained TKA prostheses implanted over a 17 year period were analysed by the Australian Orthopaedic Association National Joint Replacement Registry. The primary outcome measure was time to first revision using Kaplan Meier estimates of survivorship.

In the primary setting, the cumulative percent revision at 11 years was higher for HTKA than for FSTKA prostheses (P = 0.014). However, this finding was only significant for patient >75 years. In the revision setting, there were no differences in the revision rates for either category of prosthesis for any age group. For the indication of periarticular/periprosthetic fracture, HTKA resulted in a lower revision rate than FSTKA in both primary and revision cohorts. There were no differences in the rates of revision for infection and aseptic loosening for either prosthesis type in primary or revision settings. The revision risk for periprosthetic fracture was higher after HTKA prostheses.

Both FSTKA and HTKA prostheses provide similar outcomes in primary and revision procedures except for the setting of periarticular/periprosthetic fracture, where a HTKA should be used. In elderly patients, a FSTKA prosthesis is recommended as the risk of periprosthetic fracture is higher with a HTKA.

Both FSTKA and HTKA prostheses provide similar outcomes in primary and revision procedures except for the setting of periarticular/periprosthetic fracture, where a HTKA should be used. GSK-3 inhibitor review In elderly patients, a FSTKA prosthesis is recommended as the risk of periprosthetic fracture is higher with a HTKA.Owing to the simplicity in practice and continuous fine-tuning ability toward the binding strengths of adsorbates, the strain effect is intensively explored, especially focused on the modulation of catalytic activity in transition metal (TM) based electrocatalysts. Recently, more and more abnormal cases have been found that cannot be explained by the conventional simplified models. In this work, the strain effects in five late TMs, Fe, Co, Ni, Pd, and Pt are studied in-depth regarding the facet engineering, the surface atom density, and the d-band center. Interestingly, the irregular response of Fe lattice to the applied strain is identified, indicating the untapped potential of achieving the phase change by precise strain modulation. For the complicated high-index facets, the surface atom density has become the pivotal factor in determining the surface stability and electroactivity, which identifies the potential of high entropy alloys (HEA) in electrocatalysis. The work supplies insightful understanding and significant references for future research in subtle modulation of electroactivity based on the precise facet engineering in the more complex facets and morphologies.Potassium-ion batteries (PIBs) configurated by organic electrodes have been identified as a promising alternative to lithium-ion batteries. Here, a porous organic Polyimide@Ketjenblack is demonstrated in PIBs as a cathode, which exhibits excellent performance with a large reversible capacity (143 mAh g-1 at 100 mA g-1 ), high rate capability (125 and 105 mAh g-1 at 1000 and 5000 mA g-1 ), and long cycling stability (76% capacity retention at 2000 mA g-1 over 1000 cycles). The domination of fast capacitive-like reaction kinetics is verified, which benefits from the porous structure synthesized using in situ polymerization. Moreover, a renewable and low-cost full cell is demonstrated with superior rate behavior (106 mAh g-1 at 3200 mA g-1 ). This work proposes a strategy to design polymer electrodes for high-performance organic PIBs.Empirical evidence suggests that a fair proportion of dementia cases are preventable, that some preventive actions can be taken immediately, and others may soon be implemented. Primary prevention may target cognitively normal persons with modifiable risk factors through lifestyle and multiple domain interventions (including general cardiovascular health). While the effect on individuals may be modest, it might have a large societal impact by decreasing overall dementia incidence by up to 35%. Secondary prevention will target cognitively normal persons at high risk of dementia due to Alzheimer's disease pathology with future anti-amyloid, anti-tau, or other drugs. This approach is likely to have major benefits to both individuals and society. Memory clinics will need structural and functional changes to adapt to novel technologies and increased patients' demands, and brand-new services may need to be developed with specific skills on risk profiling, risk communication, and personalized risk reduction plans.

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