Floreswhitfield4793

Silent sinus syndrome is a rare disorder that presents a diagnostic challenge, most of the patients with this syndrome present with ophthalmological complaints without any nasal sinus symptoms, and it has a painless course and slow development. The syndrome can be diagnosed clinically and confirmed radiologically, and CT imaging is considered the gold standard for its diagnosis. The classical radiographic findings are opacification and collapse of the sinus walls. Functional endoscopic sinus surgery (FESS) is the standard gold treatment of choice to arrest the progression of the disease.

A case report of a 37-years-old-female who was complaining of severe throbbing pain since 2009, is presented here where the diagnosis of SSS was obtained in 2018, this delay in diagnosing the situation had affected the patient lifestyle tremendously.

Accordingly, knowledge of the signs and features of SSS can result in an accurate diagnosis. Suspected cases of silent sinus syndrome require prompt ear, nose, and throat referral for consideration of definitive diagnosis and surgical management. Nasal endoscopy and clinical evaluation are also essential for the diagnosis.

Our recommendation is to consider SSS as a differential diagnosis for patients with spontaneous enophthalmos and hypoglobus, even in the absence of maxillary sinus opacification. Moreover, encourage all the specialists in the medical and the dental field to communicate well together in cases like this.

Our recommendation is to consider SSS as a differential diagnosis for patients with spontaneous enophthalmos and hypoglobus, even in the absence of maxillary sinus opacification. Moreover, encourage all the specialists in the medical and the dental field to communicate well together in cases like this.

There is a lack of prognostic models predicting the overall survival (OS) of advanced breast cancer (ABC) patients in China.

Data from the China National Cancer Center database that recorded 4039 patients diagnosed with breast cancer between 1987 and 2019 were extracted and a total of 2263 ABC participants were enrolled in this study, which were further randomized 31 and divided into training (n=1706) and validation (n=557) groups. The nomogram was built based on independent predictors identified by univariate and multivariate cox regression analyses. The discriminatory and predictive capacities of the nomogram were assessed by Harrell's concordance index (C-index) and calibration plots.

Univariate and multivariate analyses found that age, Eastern Cooperative Oncology Group (ECOG) score, T-stage, N-stage, tumor subtype, the presence of distant lymph node (DLN)/liver/brain metastasis, local therapy, efficacy of first-line therapy and metastatic-free interval (MFI) were significantly related to OS (all P<0.05). These variables were incorporated into a nomogram to predict the 2-year and 3-year OS of ABC patients. The C-indexes of the nomogram were 0.700 (95% confidence interval [CI] 0.683-0.717) for the training set and 0.686 (95% CI 0.652-0.719) for the validation set. The calibration curves revealed satisfactory consistency between actual survival and nomogram prediction in both the internal and external validations. The nomogram was capable of stratifying patients into different risk cohorts.

We constructed and validated a nomogram that might serve as an efficient tool to provide prognostic prediction for ABC patients and guide the physicians to make personalized treatment decisions.

We constructed and validated a nomogram that might serve as an efficient tool to provide prognostic prediction for ABC patients and guide the physicians to make personalized treatment decisions.

To investigate the prevalence of symptomatic dry eye (SDE) on women undergoing systemic adjuvant therapy for breast cancer and its association with treatment settings.

Woman undergoing breast cancer systemic adjuvant therapy were included in exposure group. An age-matched non-treatment control group was recruited. This cross-sectional questionnaire-based study utilised validated Ocular Surface Disease Index (OSDI) and NCCN-FACT-Breast Cancer Symptom Index (NFBSI-16) questionnaires to determine the presence of SDE and investigate other breast cancer treatment complications. Additionally, demographic data and medical histories were collected.

Of 423 eligible participants, 200 in each of the control group and the exposure group were included in the final analysis. The prevalence of SDE was 59.0% in breast cancer patients with adjuvant treatment, statistically significantly higher than 25.5% in the control group (P<0.01). Additionally, exposure group experienced higher prevalence of moderate and severe Sonditions to both patients and clinicians for further specialized examination and treatment.As one of the largest protein families in plants, F-box proteins are involved in many important cellular processes. Until now, a limited number of investigations have been conducted on wheat F-box genes due to its variable structure and large and polyploid genome. Classification, identification, structural analysis, evolutionary relationship, and chromosomal distribution of some wheat F-box genes are described in the present study. A total number of 1013 potential F-box proteins which are encoded by 409 genes was identified in wheat, and classified into 12 subfamilies based on their C-terminal domain structures. Furthermore, proteins with identical or similar C-terminal domain were clustered together. Location of 409 F-box genes was identified on all 21 wheat chromosomes but showed an uneven distribution. Segmental duplication was the main reason for the increase in the number of wheat F-box genes. Gene expression analysis based on digital PCR showed that most of the F-box genes were highly expressed in the later development stages of wheat, including the formation of spike, grain, flag leaf, and participated in drought stress (DS), heat stress (HS), and their combination (HD). Of the nine F-box genes we investigated using quantitative PCR (qPCR) following fungal pathogen infection, five were involved in wheat resistance to the infection by leaf rust pathogen and one in the susceptible response. These results provide important information on wheat F-box proteins for further functional studies, especially the proteins that played roles in response to heat and drought stresses and leaf rust pathogen infection.Phytotoxicity of metals constraints plants health, metabolism and productivity. The sustainable approaches for minimizing major metals-accrued phytotoxicity have been least explored. The gasotransmitters signaling molecules such as nitric oxide (NO) and hydrogen sulfide (H2S) play a significant role in the mitigation of major consequences of metals stress. Versatile gaseous signaling molecules, NO and H2S are involved in the regulation of various physiological processes in plants and their tolerance to abiotic stresses. However, literature available on NO or H2S stand alone, and the major insights into the roles of NO and/or H2S in plant tolerance, particularly to metals, remained unclear. Given above, this paper aimed to (a) briefly overview metals and highlight their major phytotoxicity; (b) appraises literature reporting potential mechanisms underlying the roles of NO and H2S in plant-metal tolerance; (c) crosstalk on NO and H2S in relation to plant metal tolerance. Additionally, major aspects so far unexplored in the current context have also been mentioned.Duckweed is a simple aquatic floating plant having great potential in sewage treatment and bioenergy production. Duckweed rarely flowers in nature, which greatly limits its germplasm collection, conservation, and heterosis usage. Salicylic acid (SA) can efficiently induce flowering of duckweed (e.g., Lemna gibba); however, the related genes and regulatory networks remain unclear. In this work, we demonstrated that L. gibba flowering induced by SA was photoperiod-dependent, stress-involved, and abscisic acid (ABA)-disrupted. Totally 202, 78, and 413 differentially expressed (DE) genes were up-regulated, while 429, 72, and 307 were down-regulated at flower induction, flower initiation, and flowering stages, respectively. At the flower induction stage, the down-regulated genes were mainly involved in cell wall, auxin and ABA, light reaction, and abiotic stress, while the up-regulated genes were involved in development, brassinosteroid, major CHO metabolism, and redox. At the flower initiation stage, the down-regulated genes were enriched in light reaction and lipid metabolism, whereas the up-regulated genes were enriched in starch degradation and Ca2+ signaling. At the flowering stage, the down-regulated genes were significantly enriched in photosynthesis, gibberellic acid, starch synthesis, nitrogen metabolism, and redox, while the up-regulated genes were enriched in cell wall, jasmonic acid, secondary metabolism, and Ca2+ signaling. Besides, 46 transcription factors and 13 flowering-related DE genes were identified. Finally, a possible floral pathway, where LgTEM1, LgSVP, and LgFT1 might play critical roles in SA-induced flowering in L. gibba, was discussed. These findings provide a useful foundation for further investigation of genes and regulatory networks of SA-induced flowering in duckweed.To examine the dwarfing mechanism in apples, one-year-old Marubakaido (Malus prunifolia Borkh.) (invigorating) apple rootstock stools were foliar-sprayed with 860 mg L-1 of paclobutrazol (PBZ) as a single application or without. M.9 apple rootstock (dwarf) was used as a positive control. The phytohormones were estimated in the shoot bark and sub-apical shoot and gene expression in the apices of terminal shoots. Evident responses to PBZ were observed a fortnight after treatment, as the shoot and internode lengths were suppressed significantly. Endogenous indole-3-acetic acid increased in the PBZ treatment, and the polar auxin transporter genes MdPIN1 and MdLAX1 and the biosynthesis gene MdYUCCA10a were upregulated along with the MdARF2 gene. Additionally, PBZ increased the abscisic acid (ABA) concentration and the biosynthesis-related gene MdNCED1 but repressed the degradation gene MdCYP707A1. The ABA transporter gene MdAITb-like was upregulated by PBZ. The concentrations of the gibberellins (GAs) GA1 and GA4 decreased in the PBZ-treated rootstocks. The GA transporter gene MdNFP3.1-like and the signaling gene MdGID1b-like were strongly downregulated by PBZ, whereas the catabolic gene MdGA2OX2 was upregulated. PBZ treatment significantly reduced trans-zeatin (tZ) levels and downregulated the cytokinin biosynthesis gene MdIPT6 but upregulated the MdCKX7 degradation gene. Additionally, PBZ upregulated the cytokinin-related transporter genes MdPUP7-like and MdPUP9-like. Collectively, our results show that the physiological and molecular effect of PBZ was observed within two weeks, and this was indicated by the modulation of phytohormonal levels as well as transporter and other gene expression in Marubakaido apple rootstocks.

Sarcoidosis is associated with a wide range of disease outcomes including spontaneous remission and progressive courses. It is necessary to identify patients with spontaneous remission without corticosteroid treatment. This study aimed to identify the markers for predicting spontaneous remission in patients with sarcoidosis.

453 patients diagnosed with sarcoidosis at the Shanghai Pulmonary Hospital between Jan 2013 and Aug 2017 and were followed-up for more than 2 years were enrolled. Patients were divided into spontaneous remission group and non-remission group. Differences of variables between groups were analyzed by chi-square test or unpaired Student's t-test. The cumulative spontaneous remission rate was analyzed using the Kaplan-Meier method.

Of the 173 patients (stage I/II/III/IV, 53/110/6/4) without medication, 117 (67.6%) achieved spontaneous remission. The serum level of soluble interleukin-2 (IL-2) receptor (sIL-2R) and the ratio of CD4/CD8 was significantly lower and CD8

T cell was significantly higher in spontaneous remission group when compared with non-remission group (P<0.