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To provide a succinct, clinically useful summary of the management of bipolar disorder, based on the 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders (MDcpg

).

To develop the MDcpg

, the mood disorders committee conducted an extensive review of the available literature to develop evidence-based recommendations (EBR) based on National Health and Medical Research Council (NHMRC) guidelines. selleckchem In the MDcpg

, these recommendations sit alongside consensus-based recommendations (CBR) that were derived from extensive deliberations of the mood disorders committee, drawing on their expertise and clinical experience. This guideline summary is an abridged version that focuses on bipolar disorder. In collaboration with international experts in the field, it synthesises the key recommendations made in relation to the diagnosis and management of bipolar disorder.

The bipolar disorder summary provides a systematic approach to diagnosis, and a logical cl the MDcpg

. The recommendations are informed by evidence and clinical expertise and experience. The summary is intended for use by psychiatrists, psychologists and primary care physicians but will be of interest to anyone involved in the management of patients with bipolar disorder.

The bipolar disorder summary provides up to date guidance regarding the management of bipolar disorder, as set out in the MDcpg2020 . The recommendations are informed by evidence and clinical expertise and experience. The summary is intended for use by psychiatrists, psychologists and primary care physicians but will be of interest to anyone involved in the management of patients with bipolar disorder.So far, the combination of methylammonium bromide/methylammonium chloride (MABr/MACl) or methylammonium iodide (MAI)/MACl is the most frequently used additives to stabilize formamidinium lead iodide (FAPbI3 ) fabricated by the sequential deposition method. However, the enlarged bandgap due to the addition of bromide and the ambiguous functions of these additives in lead iodide (PbI2 ) transformation are still worth considering. Herein, the roles of MACl in sequentially deposited Br-free FA-based perovskites are systematically investigated. It is found that MACl can finely regulate the PbI2 /FAI reaction, tune the phase transition at room temperature, and adjust intermediate-related perovskite crystallization and decomposition during thermal annealing. Compared to FAPbI3 , the perovskite with MACl exhibits larger grain, longer carrier lifetime, and reduced trap density. The resultant solar cell therefore achieves a champion power conversion efficiency (PCE) of 23.1% under reverse scan with a stabilized power output of 23.0%. In addition, it shows much improved photostability under 100 mW cm-2 white illumination (xenon lamp) in nitrogen atmosphere without encapsulation.Nanomedicines that target specific blood cells represent an emerging strategy to improve drug biodistribution. However, the protein corona usually disrupts nanomedicine targeting to cells and tissues. Herein, instead of exploring synthetic methods to mitigate the impact of the protein corona, its natural interactions with blood cells are leveraged and turn the protein corona into an active ingredient in treating lung inflammation. It is discovered that molecularly engineered liposomes with inverse phosphocholine lipids rapidly enrich complement fragment iC3b by "voluntary opsonization," which triggers neutrophil hijacking through complement receptor 3 phagocytosis. This neutrophil targeting is cell-state dependent as only those activated by acute inflammation display efficient neutrophil reconstruction. The liposome-loaded neutrophils migrate across the alveolar-capillary barrier, accumulate in the inflamed lung parenchyma within hours, and release their payloads to kill the bacteria. This work shows that, in addition to biological cells, the protein corona can be a new platform for active and precision nanomedicine.Globally, COVID-19 lockdown measures have exposed children to more sexual, physical and emotional abuse and neglect. Although the COVID-19 pandemic is likely to have long-lasting adverse psychological effects on children, there have been comparatively few studies on children's health as compared with adults, particularly in low-income countries. Uganda implemented one of the most stringent lockdowns with bans on transportation and gatherings as well as the closure of schools, stores and places of worship. In order to address the dearth of information in less developed regions, the article aims to provide an insight into the increased cases of child abuse in Uganda during the COVID-19 pandemic. The data and information were primarily compiled from government and child welfare organisation open-source databases. The psychosocial impacts of COVID-19 have greatly disrupted the living conditions of children, limiting their access to basic needs such as food and health care. In addition, there is a lack of social support, thus putting children at an increased risk of different forms of child abuse. Since the implementation of the COVID-19 lockdown in Uganda, there has been a rise in the incidence of child abuse. Increased cases of physical and sexual abuse against children have been reported in different parts of the country as well as increased cases of child labour. To strengthen child protection during the COVID-19 pandemic, this article highlights a need for multi-level stakeholder cooperation to ensure increased funding, increased community awareness and sensitisation, early detection and effective management and referral of child abuse cases.A number of studies have reported the involvement of the ventral hippocampus (vHip) and the lateral septum (LS) in negative emotional responses. Besides these well-documented functions, they are also thought to control feeding behavior. In particular, optogenetic and pharmacogenetic interventions to LS-projecting vHip neurons have demonstrated that the vHip→LS neural circuit exerts an inhibition on feeding behavior. However, there have been no reports of vHip neuronal activity during feeding. Here, we focused on LS-projecting vCA1 neurons (vCA1→LS ) and monitored their activity during feeding behaviors in mice. vCA1→LS neurons were retrogradely labeled with adeno-associated virus carrying a ratiometric Ca2+ indicator and measured compound Ca2+ dynamics by fiber photometry. We first examined vCA1→LS activity in random food-exploring behavior and found that vCA1→LS activation seemed to coincide with food intake; however, our ability to visually confirm this during freely moving behaviors was not sufficiently reliable.