Fitzgeraldchase3737

Seven undescribed isopimarane diterpene glycosides hypoxylonoids A-G, along with five known analogues were obtained from the fungus Xylaria hypoxylon. The structures and absolute configurations of hypoxylonoids A-G were confirmed by extensive spectroscopic and single-crystal X-ray diffraction analyses. Among these compounds, the γ-lactone moiety formed between C-19 and C-6 of hypoxylonoid A; the 1,2-methyl shift of Me-18 of hypoxylonoids B and E; and the decarboxylation of C-19 of hypoxylonoid E, make them outstanding from the isopimarane family. Single crystal X-ray diffraction analyses of hypoxylonoids A, C, F, and 15-hydroxy-16-α-D-mannopyranosyloxyisopimar-7-en-19-oic acid was performed to determine their absolute structural configuration.Melatonin plays an active role in neutralizing free radicals, especially by triggering the defense system and certain enzymes that work under stress in both mammals and plant systems. Exposure to ultraviolet (UV-B) stress can be deadly for plants since UV-B can induce production of reactive oxygen species and damage nucleic acids. In the present study, to uncover the possible alleviative role of melatonin against UV-B stress, Arabidopsis thaliana plants were treated with melatonin (10 μM) and were exposed to UV-B stress for 90 min and 180 min (46 and 92 kJ m-2 d-1). Plants treated with melatonin had lower lipid peroxidation levels and higher Fv/Fm values at both time points. selleck chemical UV-B stress-induced activities of superoxide dismutase (SOD), glutathione reductase (GR) and ascorbate peroxidase (APX), but no additional induction was observed in melatonin treated groups. Moreover, melatonin differentially regulated the expression of glutathione peroxidase 2 (GPX2) and GPX7 genes under UV-B stress. Melatonin treatment did not have any effect on glutathione biosynthesis and catabolism genes. However, expression of alternative oxidase 1a (AOX1a) and AOX1d were lower in UV-B + melatonin treated plants when compared to only UV-B treated plants, which indicates lower oxidative load in mitochondria.Infectious human diseases acquired from bivalve shellfish consumption constitute a public health threat. These health threats are largely related to the filter-feeding phenomenon, by which bivalve organisms retain and concentrate pathogenic bacteria from their surrounding waters. Even after depuration, bivalve shellfish are still involved in outbreaks caused by pathogenic bacteria, which increases the demand for new and efficient strategies to control transmission of shellfish infection. Bacteriophage (or phage) therapy represents a promising, tailor-made approach to control human pathogens in bivalves, but its success depends on a deep understanding of several factors that include the bacterial communities present in the harvesting waters, the appropriate selection of phage particles, the multiplicity of infection that produces the best bacterial inactivation, chemical and physical factors, the emergence of phage-resistant bacterial mutants and the life cycle of bivalves. This review discusses the need to advance phage therapy research for bivalve decontamination, highlighting their efficiency as an antimicrobial strategy and identifying critical aspects to successfully apply this therapy to control human pathogens associated with bivalve consumption.

and purpose Music Therapy has become a consolidated strategy to relief stress in children during hospitalization, and previous research demonstrated its efficacy on individuals' health. This is a systematic review of literature on the application of music therapy with children and adolescent with cancer, with the aim of evaluating its feasibility and its benefits, in terms of physical and mental health.

Database search was carried out via PubMed, PsycINFO and SCOPUS, using an age restriction of 0-24 years and the following keywords (cancer OR oncology) AND music. Search was conducted from inception to June 2020.

From 462 studies retrieved, 19 were selected and included in this research, with 596 participants. They received three different types of music therapy receptive music therapy (n=4), active music therapy (n=9) and the combined method of receptive and active interventions (n=6). These studies indicated a significant reduction of psychological distress (n=9) and an increase in well-being (n=8). 8 articles evaluated the effects on subjective pain and other biological parameters, with inconclusive results.

Music therapy, in paediatric oncology, seems to have a good feasibility and positive effects on mental and physical health. Nevertheless, some critical issues have emerged, such as the heterogeneity of interventions and study designs, which make generalizability still difficult. These and other clinical implications are discussed.

Music therapy, in paediatric oncology, seems to have a good feasibility and positive effects on mental and physical health. Nevertheless, some critical issues have emerged, such as the heterogeneity of interventions and study designs, which make generalizability still difficult. These and other clinical implications are discussed.

Protective Behavioral Strategies (PBS) are an alcohol-specific cognitive-behavioral strategies that may be employed before, during and/or after drinking, in order to reduce alcohol consumption and related consequences, particularly in the at-risk populations. Previous research on PBS was limited to North American college students. The purpose of this study was to examine the role of PBS use in a sample of Polish adolescents attending Special Educational Centers (SEC).

Data were collected from a nationwide sample of 12-19year-old (Mean=15.8; SD=1.22) students attending SEC in Poland (N=1585; about 33% female). The self-administered anonymous questionnaires were completed on-site in the SEC. PBS were measured by the authors adaptation of the PBSS-20. Alcohol-related problems were assessed by the Polish adaptation of the measures used in the MINI-KID tool. Alcohol use was measured by a single question on drinking frequency. These two latter variables were measured in the past year timeframe. Hierarchical regression models were used to test the main and interaction effects of employing PBS (total and subscales scores) on alcohol-related problems, after adjusting for demographics (gender, family composition and type of SEC) and alcohol use.