Finnblalock2590
Recent findings revealed that both anxious and depressed mothers are more likely to have an adverse gut microbiome.
A healthy interaction of the mother-baby dyad is advantageous in ensuring mental and physical development of the offspring. Gynecologists, general practitioners and pediatricians should be alert for an early identification of mothers at risk with the aim to initiate timely targeted interventions. Further research on the role of microbiota and the possible therapeutic approaches with probiotics is required.
A healthy interaction of the mother-baby dyad is advantageous in ensuring mental and physical development of the offspring. Gynecologists, general practitioners and pediatricians should be alert for an early identification of mothers at risk with the aim to initiate timely targeted interventions. Further research on the role of microbiota and the possible therapeutic approaches with probiotics is required.
Pin1 is a propyl cis-trans isomerase and it has been associated with age-atonset of Alzheimer's disease (AD) and other pathological characteristics of AD. DNA methylation is one of the gene regulation mechanisms and it might affect the gene expression.
This study was aimed to examine the correlation between DNA methylation and gene expression of Pin1 and its effect on the risk of AD in a Chinese population.
80 AD patients and 180 normal controls were recruited in this study and their cognitive functions were assessed. Pin1 gene expression and methylation were quantified by real-time RT-PCR and Melting Curve Analysis-Methylation assay (MCA-Meth), respectively.
Our finding revealed a positive correlation between methylation and gene expression of Pin1 (p=0.001) and increased Pin1 methylation was predisposed to the risk of AD (p<0.001). CG genotype of Pin1 SNP rs2287839 was associated with higher gene expression of Pin1 (p=0.036) and the effect was only prominent in normal controls as AD patients were already methylated at Pin1 promoter. Furthermore, methylation of Pin1 was associated with better performance in cognition (p=0.018).
Our result further supported the involvement of Pin1 in AD and the increased level of Pin1 might be a protective factor for AD.
Our result further supported the involvement of Pin1 in AD and the increased level of Pin1 might be a protective factor for AD.Natural products are well known for their high potency with minimum side effects. Plant extracts are the most commonly used natural products because of their ease of availability and relatively low production cost. Berberine (BBR), a phytochemical component of some Chinese medicinal herbs (most commonlyBerberis vulgaris), is an isoquinoline alkaloid with several biological and pharmacological effects including antioxidant, anti-inflammatory, antitumour, antimicrobial, antidepressant,hepatoprotective, hypolipidemic, and hypoglycemic actions. Interestingly, multiple studies have shown that BBR is a potential drug candidate with a multi-spectrum therapeutic application. However, the oral delivery of BBR is challenged owing to its poor bioavailability. Therefore, its oral bioavailability needs to be enhanced before it can be used in many clinical applications. This review provides an overview of the various studies that support the broad range of pharmacological activities of BBR. Also, it includes a section to address the issues and challenges related with the drug and methods to improve the properties of BBR such as solubility, stability and bioavailability that may be explored to help patients reap the maximum benefit from this potentially useful drug.
Based on the long history of medicinal use of Thunbergia laurifolia, Clerodendrum disparifolium and Rotheca serrata, the extract formulations of these species T. laurifolia and C. disparifolium; T. laurifolia and R. serrata;and T. laurifolia, C. disparifolium and R. serrata, called formulas 1, 2 and 3, were created for detoxification testing to take more advantage of eachspecies.
To estimate the detoxifying effects of studiedextract formulations on human cell and tissue culture as a preclinical trial.
Themajor phytochemicals were derived by GC-MS. Thedetoxification efficacy of these formulations in cellsand DNA levelsby MTT and cometassays in toxic PBMCs (incubated with rice whisky or bathroom cleaner).
The phytochemical constituents were detected at 23.48% phytol and 43.03% oleamide in T. laurifolia; 12.88% oleamide, 20.93% 9,12,15-octadecatrien, 25.52% squalene, 22.19% butylated hydroxy toluene and 15.36% vitamin E in C. disparifolium; and 30.41% phytol, 32.78% oleamide, and12.20%, 9,12,15-octadecatrien-1-ol in R. serrata.The toxic cells treated with the plant formulas 1, 2 and 3 showed no IC50 values,but formulas 1 and 2 displayed higher efficaciesthandid formula 3. The comet assay indicated that the experiments (the treatment on toxic cells with the plant formulas) induced significant (p<0.05) DNA damage compared to the negative control due to poisoning occurring before administration of the plant formulas. The OTM of the controls was significantly (p<0.05) longer than the experimental samplesshowing significantly reduce toxicityof the created formulations.
The formulas showed high detoxification efficacies and the formulations 1 and 2resulted inhigher levels of detoxification thanthe formulation3, especially immediate treatment after receiving toxic substances.
The formulas showed high detoxification efficacies and the formulations 1 and 2resulted inhigher levels of detoxification thanthe formulation3, especially immediate treatment after receiving toxic substances.
Cognitive impairment is a common neurocognitive disorder that affects millions of worldwide people's health,related tofolate deficiency.
The present study aimed to investigate the lncRNA-mRNA functional networks associated with cognitive impairment in folate-deficient mice and elucidate their possible molecular mechanisms.
We downloaded the gene expression profile (GSE148126) of lncRNAs and mRNAs from NCBI Gene Expression Omnibus (GEO) database. Four groups of mouse hippocampi were analyzed, including 4 months (4mo) and 18 months (18mo) of folic acid (FA) deficiency/supplementation. The differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) were identified using gplots and heatmap packages. The functions of the DEmRNAs were evaluated using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The hub genes wereidentified by CytoHubba plugins of Cytoscape, and protein-protein interaction (PPI) network of deregulated mRNAs was performed using STRING database. Finallnetworks associated with cognitive impairment in folate-deficient mice, which provided support for the possible mechanisms and therapy for this disease.
This study identified the lncRNA-mRNA expression profiles and functional networks associated with cognitive impairment in folate-deficient mice, which provided support for the possible mechanisms and therapy for this disease.Vascular inflammation is responsible for many cardiovascular diseases and endothelial dysfunction is often the first trigger. Many factors can contribute to alter vascular homeostasis and despite some risk factors cannot be changed, some lifestyle changes might dramatically improve vascular function. In this regards physical activity has been identified as one of the most important interventions that can positively affect endothelial dysfunction. In recent years the discovery of irisin, a novel myokine with pleiotropic effects has caught the attention of many researchers. This review summarizes the most relevant intervention trials,evaluating irisin modifications in subjects with or without cardiovascular risk factors assigned to physical activity programs, to improve cardiovascular risk markers.Seaweeds have received great attention as a vegetarian and sustainable marine source of protein, which does not need irrigation, arable land, and fertilization. Besides, seaweeds are considered as an untapped resource for discovering bioactive compounds with health benefits where bioactive peptides have shown outstanding potential. This review provides a detailed overview of available scientific knowledge on production methods, bioactivity and application of peptides from seaweed proteins. The emphasis is on the effects from seaweed varieties and peptide production conditions on the bioactivity of the peptides and their potential health benefits. Bioactive properties of seaweed peptides, including antioxidant, antihypertensive, antidiabetic, anti-inflammatory, anticancer activities and other potential health benefits, have been discussed. It also covers current challenges and required future research and innovations for the successful application of seaweeds proteins as a sustainable source of bioactive peptides. Effects from seasonal variation of seaweed composition on the bioactivity of their peptides, difficulties in the extraction of proteins from seaweed complex structure, scalability and reproducibility of the developed methods for the production of bioactive peptides, the safety of the peptides are examples of highlighted challenges. AZ20 order Further studies on the bioavailability of the seaweed bioactive peptides and validation of the results in animal models and human trials are needed before their application as functional foods or pharmaceutical ingredients.This mini review focuses on the investigation of novel nitrogen containing steroid derivatives potentially applicable for prostate cancer treatment. It covers last decade of literature with highlights on the structure of new steroid compounds exhibiting significant activity in prostate cancer cells and possessing pharmacological potency. New derivatives of known anti-prostate cancer agents abiraterone and galeterone, new derivatives of androstane and pregnane modified with nitrogen containing heterocycles, and some related steroid derived compounds are discussed in the review.
Cellulose, huge reserves of natural polymers, have been widely applied in pharmaceutical and biomedicine fields due to its good biocompatibility, biodegradability, non-toxicity and excellent mechanical properties. At present, water-resistant metal-based and petroleum-based materials applied in medical field exists obvious problems of poor biocompatibility and high cost. Therefore, water-resistant cellulose-based materials with good biocompatibility and low price will become an attractive alternative. This review aims to summarize the preparation of water-resistant cellulose-based materials and their potential application in pharmaceutical and biomedical in recent years.
Common hydrophobic treatments of cellulose fibers or paper were overviewed. The preparation, properties and applications of water-resistant cellulose-based materials in the pharmaceutical and biomedical fields were summarized.
Common hydrophobic treatments of cellulose fibers or paper were divided into chemical modification (graft polyme. In addition, clinical medical research of water-resistant cellulose-based materials should be strengthened.Background The adoption of biomarkers as part of high-throughput, complex microarray or sequencing data has necessitated the discovery and validation of these data through machine learning. Machine learning has remained a fundamental and indispensable tool due to its efficacy and efficiency in both feature extraction of relevant biomarkers as well as the classification of samples as validation of the discovered biomarkers. Objectives This review aims to present the impact and ability of various machine learning methodologies and models to process high-throughput, high-dimensionality data found within mass spectrometry, microarray, and DNA/RNA-sequence data; data that precluded biomarker discovery prior to the use of machine learning. Methods A vast array of literature highlighting machine learning for biomarker discovery was reviewed, resulting in the eligibility of 21 machine learning algorithms/networks and 3 combinatory architectures, spanning 17 fields of study. This literature was screened to investigate the usage and development of machine learning within the framework of biomarker discovery.
