Feldmantopp3038

This article prepared a simvastatin-NLCs for the treatment of arteriosclerotic occlusive disease of lower limbs. Taking the size distribution, polydispersity coefficient, encapsulation efficiency and drug loading of simvastatin-NLCs as evaluation indicators, various prescription factors of simvastatin- NLCs were investigated. The in vitro release behavior and stability of simvastatin-NLCs were also investigated. A hyperlipidemia rat model was established using high-fat diets. SD rats fed ordinary diet were set as normal control groups. https://www.selleckchem.com/ 20 rats, 20 in the simvastatin group and 20 in the simvastatin nanocarrier group. After 5 weeks of drug intervention, the rats were sacrificed and the aorta was taken to determine the smooth muscle cell apoptosis rate. Studies have shown that simvastatin nanocarriers can more effectively reduce blood lipids in hyperlipidemia rats, increase the rate of smooth muscle cell apoptosis in hyperlipidemia rats, and delay the onset of atherosclerosis.Because some asthma patients have different types of inflammatory cells in their bodies, they cannot get relief with traditional drugs. However, the nano drug delivery system can realize efficient drug delivery, inflammatory cells and intracellular targeting, and the apoptosis of inflammatory cells. This article aims to comprehensively evaluate the effects of montelukast sodium combined with graphene oxide nanomaterials on improving the clinical symptoms and airway inflammation of children with bronchial asthma, with a view to further improving the clinical treatment of children with bronchial asthma. The results show that montelukast sodium can improve lung function in patients with asthma, and also has important effects such as anti-inflammatory and regulating immune function. After exposure to graphene oxide, the level of oxidative stress in mice increased with brightness and humidity, demonstrating the role of T oxidative stress in the development of asthma. In addition, nanocarriers assist co-loaded drugs to deepen and enrich the pulmonary inflammation site, further achieving effective mitochondrial targeted drug delivery, thereby enhancing the inhibitory effect of anti-apoptotic proteins, leading to inflammatory cell apoptosis.Breast cancer has become the first malignant tumor in women. Early detection and early treatment are the key to improve the prognosis of breast cancer patients. The key to the screening and diagnosis of breast cancer lies in the qualitative differential diagnosis of breast nodules. With the rapid development of MRI technology, especially the application of high field strength and ultra-high field strength, the role of breast MRI is increasingly prominent. MRI has the advantages of safety, no ionizing radiation, high resolution of soft tissue, high sensitivity and specificity for the diagnosis of early breast cancer. Multimodal imaging based on reinforcement learning and iron carbon nanoparticles plays an important role in the diagnosis of breast nodules. This paper first discusses the application of iron carbon nanoparticles and breast MRI multimodal imaging technology in tumor treatment, and then studies the application of iron carbon nanoparticles mediated multimodal imaging in the diagnosis of breast nodules through experimental methods. The experimental results show that multimodal imaging has a good effect in the diagnosis of breast nodules, which is helpful for the prevention and treatment of breast nodules.In order to investigate the role of composite nanoparticles in the immune stage, we observed the expression of R-1 in anti-mycotic infection of human corneal epithelial cells, and divided the experiment into control group, fungal stimulation group, Gw507 blocking group and Dectin-1. In the inhibitor group, the immune effect of human corneal epithelial cells was studied. Subsequently, the expression of total R-1 and phosphorylated form of p-R-1 in each experimental group was detected by western blot method. Finally, real-time quantitative PCR was used to detect the expression of factors IL-6 and IL-8. We concluded that p-R-1 was slightly expressed in the control group. After 15 minutes of fungal stimulation, the expression level in the experimental group was significantly higher than that in the blank group, and the difference was statistically significant (p less then 0.05). In the blocking group of two different inhibitors, the expression of p-R-1 was lower than that in the fungal stimulation experimental group, and the difference was statistically significant (p less then 0.05). Therefore, R-1 is expressed in corneal epithelial cells and the fungus exerts its antifungal effect through the Dectin-1 signaling pathway.In recent years, with the rapid development of nano-biotechnology and biomedicine, people have provided new ideas and methods for disease diagnosis and treatment. Nano-sulfides with unique two-dimensional structures and special physicochemical properties have begun to be applied to biology and medical field. Relevant research results show that nano-sulfides have good effects in tumor photothermal treatment, in vivo multimodal imaging, antitumor drug delivery, biosensors and tissue engineering, showing their potential application value. In view of the broad application prospects of nano-sulfides in the field of nano-biomedicine, in the image reconstruction stage, before starting to use artificial intelligence algorithm models, first explore the application of iterative optimization algorithms in the process of magnetic resonance image reconstruction. Taking magnetic resonance imaging as an example, for the detected ligament trauma area, we use learned an artificial intelligence model for diagnosis of multiple ligament trauma of the knee joint and postoperative femoral nerve block.Nanomaterials are used as a new type of antibacterial agent in clinical medical research projects due to their unique physical and chemical properties. In this study, silane coupling method was used to coat nano-silver particles on titanium sheets to make the smooth titanium surface have antibacterial properties. Scanning electron microscope to observe the surface morphology of silane coupling modified titanium plate, the shape and size of nano-silver particles, and the adhesion on titanium plate; X-ray energy spectroscopy and line scan analysis of each element on the titanium wafer; X-ray photoelectron spectroscopy quantitative analysis of surface elements on the titanium wafer. The experimental group was nano-silver modified titanium sheet, and the control group was smooth titanium sheet. The experimental results show that the titanium material loaded with nano-silver particles has better antibacterial performance in the orthodontic process than ordinary materials. This material is highly safe and can be promoted for use.Chronic pulmonary heart disease is a common respiratory disease. Helicobacter pylori infection can lead to the occurrence of chronic pulmonary heart disease. However, most drugs for chronic pulmonary heart disease caused by helicobacter pylori are lack of tissue specificity. At the same time, due to the blocked blood circulation in the ischemic area, the distribution of drugs in the ischemic area is often not ideal. The gastroscope technology of nano carbon can make the drug release in the focus as much as possible, and can achieve the goal of targeted treatment. This paper mainly studies the application of the gastroscope technology based on nano carbon in the remedy of chronic pulmonary heart disease caused by helicobacter pylori. After 8 weeks of treatment, the indexes of right heart function in the two groups TAPSE and RVMPI were better than before treatment, and the improvement degree in the remedy group was more obvious than that in the control group (P 0.05). In addition, the gastroscope of nano carbon can also reduce UA and TG in blood. The overall response rate was 93.75% in the remedy group, which was higher than that in the control group (P less then 0.05).Ulcerative colitis (UC) is a non-specific intestinal inflammatory disease. UC occurred in developed countries in the past, but in the past 20 years, the incidence of UC in developing countries has also shown a clear upward trend. The hospitalization rate and surgical rate of UC have been high, and may lead to the occurrence of intestinal malignant tumors, which has greatly affected the quality of life and life expectancy of patients. Because of this, how to effectively treat UC has become a hotspot in modern gastrointestinal diseases. Due to the limitation of the dosage form of the drug and the special environment of the gastrointestinal tract, traditional oral drugs have the disadvantage of not being able to make the drug effective in specific lesions when treating inflammatory bowel disease. Therefore, it is of great scientific significance and application value to develop drug carriers that can target the inflammatory sites and slow-release drugs to treat inflammation. In this study, TNBS method was used tt. TUNEL staining results showed that the level of apoptosis in the colon injury site of rats treated with modified drug-loaded porous silicon nanoparticles was reduced. The test results of drug concentration in rat colon tissue blood also proved that porous silicon nanoparticle drug-loading system can reduce the release of inflammatory factors in vivo. Based on the TNBS-induced UC rat model, this paper evaluates the therapeutic effect of modified drug-loaded porous silicon nanoparticles. The results show that in the treatment of ulcerative colitis, the nanoparticle drug-loaded system is a more effective treatment way.Recurrent oral ulcer is a common oral mucosal disease. Due to its periodic and recurrent characteristics, the onset of burning pain is unbearable, which brings great inconvenience to the patient's life and seriously affects the patient's quality of life. There are certain limitations to conventional drug therapy. With the rapid development of nanotechnology, the obvious advantages of nanotechnology such as targeting, controlled release, biocompatibility is obviously shown. The combination of nanotechnology and medical research has led to the emergence of polymer nanoparticles and ligands. Nano-drugs for gene therapy, and many other new nano-drug carriers, polymer micelle is a new type of nano drug carrier that has appeared in recent years. It has both a hydrophilic shell and a hydrophobic core, and has a variety of excellent properties, such as higher stability in vivo and in vitro, and poorly soluble drugs. In this paper, a new method for treating recurrent oral ulcers based on a new nano-drug carrier was studied. Because of the hydrophilicity and biocompatibility of oral cell surface proteins, the research progress of nanopharmaceutical carrier in the treatment of recurrent oral ulcers is reviewed. The experimental results show that the method has good reproducibility and high efficiency in the treatment of recurrent oral ulcers. It is used to explore the application and progress of nanotechnology in the diagnosis and treatment of recurrent oral ulcers, and to provide new ideas for the clinical diagnosis and treatment of recurrent oral ulcers. This new technical method has wide practical application value.