Feddersenkragelund1454

Due to the feature learning nature of deep learning, it is one of the most promising and powerful techniques for real time applications. However, the field of deep learning is relatively new and need further research for its full utilization. Similarly, lifelong machine learning paves the way for real time HSI applications but needs further research to incorporate the seasonal variations in food quality. Further, the research gaps in machine learning techniques for hyperspectral image analysis, and the prospects are discussed.ESBL-producing Enterobacterales (ESBL-E) remain a significant global threat. In several regions of the world, ESBLs are produced by over half of Escherichia coli or Klebsiella pneumoniae infections, contributing to significant morbidity and mortality. Though it is accepted that carbapenems are effective for the treatment of invasive ESBL-E infections, controversy remains as to whether carbapenem alternatives can be considered in select cases. Indiscriminate carbapenem use for the treatment of ESBL-E infections will likely further the international antimicrobial resistance crisis, underscoring the importance of investigating the role of non-carbapenem options. In this issue of JAC-Antimicrobial Resistance, we present a PRO/CON debate exploring whether carbapenems are necessary for all infections caused by ceftriaxone-resistant Enterobacterales.Background The availability of instrumented treadmills that can apply unexpected perturbations during walking has made gait perturbation training more popular in clinical practice. To quantify and monitor balance recovery while training, easy to use measures are needed and may be based on integrated force plate data. Therefore, we aimed to quantify and evaluate different implementations of the recovery performance measure based on center of pressure data. Methods Recovery performance was calculated based on differences in center of pressure trajectories between unperturbed walking and balance recovery after a perturbation. Five methodological choices leading to 36 different implementations were evaluated. Test-retest reliability, effect sizes, and concurrent validity were evaluated against trunk velocity measures. Results Differences in measures of (dis-)similarity, time normalization and reference data affected reliability, sensitivity and validity and none of the performance measure implementations based on center of pressure trajectories was superior on all criteria. Measures assessing perturbation effects on trunk velocities provided more reliable and sensitive recovery outcomes. Discussion Different implementations of the recovery performance measure can be chosen dependent on constraints imposed in the clinical setting. Conclusion Quantifying recovery performance based on center of pressure data is possible and may be suitable to monitor improvement in recovery performance after gait perturbations in specific clinical setups. Validity of performance measures in general requires further attention.During the Spanish Civil War (SCW) 1936-1939, many young working-class sportsmen volunteered. They were both physically and politically active and some of them outstanding athletes. The search of these unknown men has just begun. Doomed Youth is a tribute to them and the first step toward a bigger attempt to better comprehend the role of sportsmen volunteers enlisted during the first months of the SCW, a fact that to date has received little scholar attention. Archival research, especially war combatants' family records as well as newspaper archives, oral memories of the protagonists left alive, and historical contextualization were defined as the appropriate methods to conduct the research. This paper is devoted to one of these young volunteers, Antonio Cánovas, recently dead in 2018 at the age of 98, whose life story in the 1930s and 1940s may be taken as the epitome of the young working-class sportsman of the cutting-edge regions of Spain in the first half of the 20th century youngsters aware of their political and social rights whose dreams of social justice and active life were dashed by the war.

Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine and an important regulator of innate immune responses. We hypothesised that serum concentrations of MIF are associated with disease severity and outcome in patients with decompensated cirrhosis and acute-on-chronic liver failure (ACLF).

Circulating concentrations of MIF and its soluble receptor CD74 (sCD74) were determined in sera from 292 patients with acute decompensation of cirrhosis defined as new onset or worsening of ascites requiring hospitalisation. Of those, 78 (27%) had ACLF. Short-term mortality was assessed 90 days after inclusion.

Although serum concentrations of MIF and sCD74 did not correlate with liver function parameters or ACLF, higher MIF (optimum cut-off >2.3 ng/ml) and lower concentrations of sCD74 (optimum cut-off <66.5 ng/ml) both indicated poorer 90-day transplant-free survival in univariate analyses (unadjusted hazard ratio [HR] 2.01 [1.26-3.22];

= 0.004 for MIF; HR 0.59 [0.38-0.92];

= 0.02 for sCs with cirrhosis and ascites. We show that patients with high serum levels of the inflammatory cytokine macrophage migration inhibitory factor (MIF) alongside low levels of its binding receptor sCD74 in blood indicate an increased mortality risk in patients with ascites. The cirrhotic liver is a relevant source of elevated circulating MIF levels.

Inflammatory processes contribute to the increased risk of death in patients with cirrhosis and ascites. We show that patients with high serum levels of the inflammatory cytokine macrophage migration inhibitory factor (MIF) alongside low levels of its binding receptor sCD74 in blood indicate an increased mortality risk in patients with ascites. The cirrhotic liver is a relevant source of elevated circulating MIF levels.Among the large population of patients with non-alcoholic fatty liver disease (NAFLD), identifying those with advanced disease remains challenging. Many patients are diagnosed late, following the development of liver-related complications, leading to poor clinical outcomes. Accumulating evidence suggests that using non-invasive tests for liver fibrosis in patients with metabolic risk factors improves the detection of patients in need of specialised management and is cost-effective. Because of the vast number of patients requiring evaluation, the active participation of general practitioners and physicians who manage patients with metabolic disorders, such as diabetologists, is crucial; this calls for the increased awareness of NAFLD beyond liver clinics. Non-invasive case-finding strategies will need to be further validated and generalised for upcoming drug therapies to have the required impact on the worldwide burden of NAFLD.Robots are likely to become important social actors in our future and so require more human-like ways of assisting us. We state that collaboration between humans and robots is fostered by two cognitive skills intention reading and trust. An agent possessing these abilities would be able to infer the non-verbal intentions of others and to evaluate how likely they are to achieve their goals, jointly understanding what kind and which degree of collaboration they require. For this reason, we propose a developmental artificial cognitive architecture that integrates unsupervised machine learning and probabilistic models to imbue a humanoid robot with intention reading and trusting capabilities. Our experimental results show that the synergistic implementation of these cognitive skills enable the robot to cooperate in a meaningful way, with the intention reading model allowing a correct goal prediction and with the trust component enhancing the likelihood of a positive outcome for the task.Many metabolic pathways, including lipid metabolism, are rewired in tumors to support energy and biomass production and to allow adaptation to stressful environments. Neuroblastoma is the second deadliest solid tumor in children. Genetic aberrations, as the amplification of the MYCN-oncogene, correlate strongly with disease progression. Yet, there are only a few molecular targets successfully exploited in the clinic. Here we show that inhibition of fatty acid synthesis led to increased neural differentiation and reduced tumor burden in neuroblastoma xenograft experiments independently of MYCN-status. This was accompanied by reduced levels of the MYCN or c-MYC oncoproteins and activation of ERK signaling. Importantly, the expression levels of genes involved in de novo fatty acid synthesis showed prognostic value for neuroblastoma patients. Our findings demonstrate that inhibition of de novo fatty acid synthesis is a promising pharmacological intervention strategy for the treatment of neuroblastoma independently of MYCN-status.L-lactate has energetic and signaling properties, and its availability is modulated by activity-dependent stimuli, which also regulate adult hippocampal neurogenesis. Studying the effects of L-lactate on neural precursor cells (NPCs) in vitro, we found that L-lactate is pro-proliferative and that this effect is dependent on the active lactate transport by monocarboxylate transporters. Increased proliferation was not linked to amplified mitochondrial respiration. Instead, L-lactate deviated glucose metabolism to the pentose phosphate pathway, indicated by increased glucose-6-phosphate dehydrogenase activity while glycolysis decreased. Knockout of Hcar1 revealed that the pro-proliferative effect of L-lactate was not dependent on receptor activity although phosphorylation of ERK1/2 and Akt was increased following L-lactate treatment. Together, we show that availability of L-lactate is linked to the proliferative potential of NPCs and add evidence to the hypothesis that lactate influences cellular homeostatic processes in the adult brain, specifically in the context of adult hippocampal neurogenesis.Liver aging impairs the ability of hepatocyte regeneration. Recent studies have found that oxytocin (OT) plays an important role in promoting tissue repair and maintaining differentiation and regeneration of stem cells. Here, we reported that OT receptors, which are specifically located in hepatocytes, decrease with aging in human and mice. Interestingly, the level of serum OT also decline with age. Notably, OT promotes hepatocyte regeneration only in aged mice but not in young mice in vitro and in vivo. Further studies reveal that OT promotes autophagy in either AML12 mouse hepatocytes or aged mice after partial hepatectomy or with CCl4-induced acute liver injury. In conclusion, OT promotes liver regeneration, especially in aged mice, which may be achieved by promoting autophagy. All these results support the possibility of OT and its analog being a potent anti-aging drug and promote liver rejuvenation.Near-infrared (NIR) emission is useful for numerous practical applications, such as communication, biomedical sensors, night vision, etc., which encourages researchers to develop materials and devices for the realization of efficient NIR organic light-emitting devices. Recently, the emerging organic thermally activated delayed fluorescence (TADF) emitters have attracted wide attention because of the full utilization of electron-generated excitons, which is crucial for achieving high device efficiency. Up to now, the TADF emitters have shown their potential in the deep red/NIR region. Considering the color purity and efficiency, however, the development of NIR TADF emitters still lags behind RGB TADF emitters, indicating that there is still much room to improve their performance. HA15 mouse In this regard, this perspective mainly summarizes the past progress of molecular design on constructing TADF NIR emitters. We hope this perspective could provide a new vista in developing NIR materials and enlighten breakthroughs in both fundamental research and applications.