Fanningmcknight0218

Replication was efficient in both mammalian species, causing mild infection, with virus primarily limited to respiratory tract tissues. The H7 viruses demonstrated a capacity to transmit to naïve ferrets in a direct contact setting. These data support the need to perform routine risk assessments of LPAI H7 subtype viruses, even in the absence of confirmed human infection.Mining activities expose workers to diverse working conditions, rotational shifts and high altitude-related hypobaric hypoxia. Separately, each condition has been reported having a negative impact on miners' health risk; however, the combination of both stressors has been poorly explored. The present study aimed to analyse the effects of exposure to rotational work shift (RWS) alone or in combination with high altitude-related chronic intermittent hypobaric hypoxia (CIHH) on cardiometabolic, physical activity and sleep quality related markers in copper miners from Los Pelambres mine in Chile. One hundred and eleven male miners working in RWS with or without CIHH were included. Anthropometrics measures, sleep quality assessment, physical activity level (PAL) and handgrip strength were evaluated. Exposure to CIHH exacerbated the detrimental effects of RWS as miners exposed to the combination of RWS and CIHH where more obese and had a wider neck circumference, reduced PAL at work and worsened sleep quality. Practitioner summary The purpose was to assess cardiometabolic health and sleep quality markers associated with the combined effects of rotational shift work and high altitude-related intermittent hypobaric hypoxia in miners. Findings showed a wider neck circumference, lower physical activity level and higher prevalence of poor sleep quality in exposed miners. Abbreviations ANOVA analysis of variance; BM body mass; BMI body mass index; CI confidence intervals; CIHH chronic intermittent hypobaric hypoxia; CV cardiovascular; CVR cardiovascular risk; HA high altitude; HACE high-altitude cerebral edema; HGS handgrip strength; IPAQ-SF International Physical Activity Questionnaire - Short Form; LSD Fisher's least standardized difference; MANCOVA multivariate general lineal model; MET metabolic equivalent; PAL physical activity level; PSQI Pittsburg sleep quality index; RWS rotational work shift; WHR waist-to-hip ratio.Purpose This study explored the genetic testing experiences of adolescents and young adults (AYAs; aged 15-39 years) with, or at 50% risk of, an early onset cancer predisposition syndrome Li-Fraumeni syndrome (LFS).Design We used interpretive description and conducted semi-structured interviews with 30 AYAs (mean age 25.5 years) 26 with LFS and four at 50% risk. Findings were developed using team-based, inductive thematic analysis.Findings Participants reported genetic testing uptake to reduce uncertainty about their gene status and to access cancer risk management. Learning their gene status, however, introduced a new uncertainty about living with high multi-organ cancer risk. Participants preoccupied with surviving cancer during diagnostic testing underestimated the implications of LFS. JW74 Reliance on family at this life stage complicated decision-making for genetic testing, especially among adolescents.Conclusion AYAs undergoing genetic testing for LFS have unique support needs based on their life stage and require developmentally appropriate psychosocial care.This study aimed to analyse the training intensity distribution (TID) of a group of 7 world-class middle- and long-distance runners over 50 weeks using two different approaches to organise TID zones (1) based on individual specific race pace and; (2) based on physiological parameters. Analysed training data included training volume, intensity and frequency. The average weekly volume for the group was 135.4 ± 29.4 km·week-1. Training volumes for Z1, Z2 and Z3 were 88.5 ± 1.1%, 7.4 ± 0.8% and 4.1 ± 0.7% respectively for race-pace based approach, and 87.2 ± 1.2%, 6.1 ± 0.7% and 6.6 ± 0.9% respectively for the physiological approach. Differences were found between the approaches in Z2 (large effect, ES = 1.20) and Z3 (moderate effect, ES = 0.93). The approach based on race-pace zones produced pyramidal distributions in both middle- and long-distance runners across all phases of the season. The physiological approach produced polarised and pyramidal distributions depending of the phase of the season in the middle-distance runners, and pyramidal type TID across all phases of the season in the long-distance runners. The results of this study demonstrate that the training analysis in a world-class group of runners shows different TID when assessed relative to race pace versus to physiological zones. This highlights a potential deficiency in training analysis and prescription methods which do not make reference to specific performance. An approach which makes reference to both physiological and performance measures may allow for a more consistent and logical analysis.In this study, biosynthesis of silver nanoparticles (AgNPs) using two species of cyanobacteria, Anabaena variabilis (Kütz) and Spirulina platensis (Gomont) was investigated and evaluated for dye removing capacity. The formation of AgNPs was detected by the change in colour using UV-Vis spectroscopy and further characterised by X-ray diffraction (XRD), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). The obtained AgNPs were spherical to oval with average particle size of 17.9 and 26.4 nm for S. platensis and A. variabilis, respectively. These AgNPs were applied as bio-sorbent for the removal of malachite green (MG) dye released into wastewater. Within the tested initial concentration range of MG, the reaction exhibited first order kinetics model as monitored via UV spectroscopy. As the dye concentration decreased, the removal efficiency increased to reach 93% for S. platensis and 82% for A. variabilis AgNPs. The results also indicated that increased AgNPs concentration enhanced the MG removal with an efficiency up to 88% and 81% for S. platensis and A. variabilis AgNPs, respectively. The smaller particle diameter and larger specific surface area of S. platensis AgNPs enabled boosted catalytic activity for dye removal than those of A. variabilis. After the treatment with AgNPs, the resultant dye- AgNPs-free effluent proved non-toxic to Triticum aestivum L (Giza 171) seedlings, implying their safety for cultivation practices.