Fabershapiro1161

The volcano-type trend of OER catalytic performance is obtained to show the best Co@GY/Ni@GY catalyst for the OER with an over-potential of 0.38 V, indicating that higher catalytic performance arises from moderate interfacial electron transfer. These results arouse a re-thinking of the intrinsic activity origins of single-atom catalysts (SACs) and offer a new strategy for the structure designing of SACs.Several studies published in the last decade suggest that the beneficial role of extra-virgin olive oil (EVOO) in human health is mostly attributable to the main secoiridoid derivatives (oleuropein, oleocanthal, and oleacein). Anti-cancer properties have also been demonstrated for certain compounds present in small quantities in EVOO, including oleuropein and hydroxytyrosol, which have been extensively studied, while minor attention has been given to the most abundant secoiridoid oleacein. The aim of our research was to study the molecular mechanisms underlying the anti-proliferative and anti-metastatic capacity of oleacein in the SH-SY5Y human neuroblastoma cell line. Our results demonstrate that oleacein is able to reduce the proliferation of the SH-SY5Y cells by blocking the cell cycle in the S phase and inducing apoptotic cell death through the increase in both Bax and p53 as well as a reduction in the Bcl-2 expression and STAT3 phosphorylation. Moreover, oleacein caused reduction in the SH-SY5Y cell adhesion and migration. Overall, these findings indicate that oleacein exerts anti-cancer effects against neuroblastoma cells, suggesting a promising role as a candidate against this type of cancer.In the last few decades, two-dimensional monolayer films of gold nanoparticles (2D MFGS) have attracted increasing attention in various fields, due to their superior attributes of macroscopic size and accessible fabrication, controllable electromagnetic enhancement, distinctive optical harvesting and electron transport capabilities. This review will focus on the recent progress of 2D monolayer films of gold nanoparticles in construction approaches, surface engineering strategies and functional applications in the optical and electric fields. The research challenges and prospective directions of 2D MFGS are also discussed. This review would promote a better understanding of 2D MFGS and establish a necessary bridge among the multidisciplinary research fields.The reaction of Co(OAc)2·4H2O with a sterically hindered phosphate ester, LH2, afforded a tetranuclear complex, [CoII(L)(CH3CN)]4·5CH3CN (1) [LH2 = 2,6-(diphenylmethyl)-4-isopropyl-phenyl phosphate]. The molecular structure of 1 reveals that it is a tetranuclear assembly where the Co(ii) centers are present in the alternate corners of a cube. The four Co(ii) centers are held together by four di-anionic [L]2- ligands. The fourth coordination site on Co(ii) is taken by an acetonitrile ligand. Changing the Co(ii) precursor from Co(OAc)2·4H2O to Co(NO3)2·6H2O afforded a mononuclear complex [CoII(LH)2(CH3CN)2(MeOH)2](MeOH)2 (2). In 2, the Co(ii) centre is surrounded by two monoanionic [LH]- ligands and a pair of methanol and acetonitrile solvents in a six-coordinate arrangement. 1 has been found to be an efficient catalyst for electrochemical water oxidation under highly basic conditions while the mononuclear analogue, 2, does not respond to electrochemical water oxidation. The tetranuclear catalyst has excellent electrochemical stability and longevity, as established by chronoamperometry and >1000 cycle durability tests under highly alkaline conditions. Excellent current densities of 1 and 10 mA cm-2 were achieved with overpotentials of 354 and 452 mV respectively. The turnover frequency of this catalyst was calculated to be 5.23 s-1 with an excellent faradaic efficiency of 97%, indicating the selective oxygen evolution reaction (OER) occurring with the aid of this catalyst. A mechanistic insight into the higher activity of complex 1 towards the OER compared to that of complex 2 is also provided using density functional theory based calculations.The different chemical states and locations of Ni species in HZSM-5 result in different directions of CH4 reaction. Supported Ni clusters caused complete CH4 decomposition, while Ni-exchanged sites anchored at Brønsted acid sites, can appropriately activate CH4 into CHx species which are important precursors to produce aromatics. This study suggests a catalyst construction strategy for selective conversion of CH4 towards value-added chemicals by placing active metal at specific sites.The synthesis of carbon nanotubes (CNTs) from CO2 is an attractive strategy to reduce CO2 emission, but involves extreme reaction conditions and has low scalability. This work introduces continuous chemical vapor deposition for the conversion of CO2 to CNTs using the NaBH4 reductant and NiCl2 catalyst. Multi-walled CNT fibers were synthesized from gaseous CO2 under mild conditions (500-700 °C and 1 atm). Based on in situ analyses, the proposed mechanism behind the formation of CO2-derived CNTs (CCNTs) is CO2 activation and subsequent hydroboration for the generation of methane, which can induce the growth of CCNTs on the catalyst. Their intrinsic properties give rise to an enhanced capacitive performance. The boron and oxygen of CCNTs provide a pseudo-capacitance of 302 F g-1 at a low charging rate of 0.1 A g-1 in 1 M TEABF4/acetonitrile. The mesoporous networks between CCNT fibers enhance ion transport at a high current density of 205 A g-1, leading to an outstanding energy density of 13 W h kg-1 at a high power density of 115 kW kg-1. A well-developed graphitized structure of CCNTs contributes to the reduction of the electrochemical resistance and leads to their superior stability at 65 °C during 10 000 cycles.Human Pancreatic Amylase (HPA) is an important target for prevention and treatment of type 2 diabetes. Acarbose is a currently available drug acting as a HPA inhibitor, but its gastrointestinal side-effects cannot be neglected. Thus, developing novel HPA inhibitors with no side-effects is of great importance. Herein, we adopted a structure-based design approach and discovered a potent HPA inhibitor, malvidin 3-O-arabinoside (M3A), from the natural anthocyanin database. We identified M3A as an effective HPA inhibitor through virtual screening, enzyme activity and enzyme kinetic assays. We reported the structure and activity relationships as both the anthocyanidin core and glucosyl group affected the HPA inhibitory effect of anthocyanins. GA-017 research buy Molecular dynamics studies indicated that the HPA inhibition of M3A occurred via its binding to the HPA key catalytic residues Arg195 and Asp197 through stable hydrogen bonding. In addition, M3A was found to reduce α-helix fractions and increase β-sheet fractions in CD spectrometry.