Erikssonlinde2527

8%. The mean LogMAR VA was improved by 0.06 LogMAR (20/68) in the worse eye (p=0.97) and 0.08 LogMAR (20/31) in the better eye (p=0.7). The visual function that impairs daily activity was decreased by 55.4% (p=0.08). Patients shunted within one month of presentation had a significantly higher rate of headache (p=0.04) and VA improvement (p less then 0.001). Conclusions VPS and LPS are effective in improving visual symptoms and headache in patients with IIH.Objective Many treatment options for osteoporotic vertebral fractures are available, however, there exist limited and variable reports on efficacy of individual therapies. The objective of this study was to systematically review the literature for evidence of efficacy of spinal orthoses for osteoporotic vertebral fractures. Methods A systematic review of the Pubmed database was performed. Two reviewers evaluated for eligibility. Randomized controlled trails (RCTs), prospective non-randomized, prospective single-arm, and retrospective comparative studies of treatment of acute osteoporotic vertebral fractures with spinal orthoses were included. Results Sixteen studies were included five RCTs, six non-randomized prospective comparative studies, one retrospective case-control study, and four prospective single arm studies. Four studies (3 single arm, 1 non-randomized) provided low quality evidence that bracing, with or without bedrest, was safe. One non-randomized and one single arm study provided low quality evidence that bracing improved pain and disability. Four studies demonstrated rigid brace was equivalent to soft brace or no brace (2 high quality RCTs, 2 non-randomized, 1 low quality RCT). Two non-randomized and one case-control study demonstrated a benefit of kyphoplasty over bracing alone (low quality). Two RCTs provided low quality evidence that bracing was superior to no brace and one non-randomized study provided low quality evidence that a dynamic brace was superior to a rigid orthosis. Conclusions Limited evidence suggests safety of spinal orthoses for treatment osteoporotic compression fractures. Currently, there is not compelling evidence to suggest rigid orthosis is superior to soft orthosis or no bracing. Kyphoplasty may be of benefit to select patients.Background Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-Cov-2, resulting in severe acute respiratory syndrome, with high potential of spreading and infecting humans worldwide. Since December 2019, when the virus was identified in humans, the literature on COVID-19 has grown exponentially and extrarespiratory symptoms including neurologic symptoms are increasingly highlighted. Methods Given the high and increasing number of publications reporting neurologic involvements of SARS-Cov-2, we thought that providing an update for neurologic complications of COVID-19 would be useful for physicians and especially young trainees in neurology and neurosurgery. Indeed, in this review we discuss several neurologic aspects reported in the literature to date including the evidence and pathways of neuroinvasion in COVID-19 and the main neurologic disorders reported in the literature to date, as well as future perspectives and the potential long-term consequence of current neuroinfection in COVID-19 patients. Results Currently, there is convincing evidence that SARS-CoV-2, the etiologic agent of COVID-19, can affect the nervous system, with damage and neurologic alterations. CT7001 research buy These neurologic disorders are grouped into several categories, ranging from nonspecific and moderate symptoms such as headache, myalgia, and hyposmia to severe symptoms including cerebrovascular disease and intracranial infections. Severe neurologic symptoms such as acute cerebrovascular disease occur only in a minority of patients with usual risk factors and are associated with poor outcome. However, most COVID-19 patients exhibit only minor or mild neurologic symptoms. Conclusions Management of COVID-19 patients should include early clinical, radiologic, and laboratory neurologic assessment, with a close follow-up, especially in severe forms. Future studies should assess late and long-term consequences of current COVID-19 patients with neurologic involvement.Background The coronavirus 2019 (COVID-19) pandemic has had a dramatic impact on health care systems and a variable disease course. Emerging evidence demonstrates that severe acute respiratory syndrome coronavirus 2 is associated with central nervous system disease. We describe central nervous system manifestations in critical patients with COVID-19 at our tertiary center. Methods We conducted a single-center retrospective analysis of all actively critical patients with COVID-19 admitted to our tertiary care academic center in New Orleans, Louisiana, on April 22, 2020, with new onset of neurologic disease. Patients were grouped into 1 of 3 categories according to imaging and clinical features; encephalopathy, acute necrotizing encephalopathy, and vasculopathy. Results A total of 27 of 76 (35.5%) critical patients with COVID-19 met inclusion criteria. Twenty patients (74%) were designated with COVID-19-associated encephalopathy, 2 (7%) with COVID-19-associated acute necrotizing encephalopathy, and 5 (19%) with COVID-19-associated vasculopathy. Sixty-three percent of neurologic findings were demonstrated on computed tomography, 30% on magnetic resonance imaging, and 44% on electroencephalography. Findings most often included ischemic strokes, diffuse hypoattenuation, subcortical parenchymal hemorrhages, and focal hypodensities within deep structures. Magnetic resonance imaging findings included diffuse involvement of deep white matter, the corpus callosum, and the basal ganglia. For patients with large-territory ischemic stroke, all but one displayed irregular proximal focal stenosis of the supraclinoid internal carotid artery. Conclusions Analysis of active critical COVID-19 admissions at our revealed a high percentage of patients with new neurologic disease. Although variable, presentations followed 1 of 3 broad categories. A better understanding of the neurologic sequalae and radiographic findings will help clinicians mitigate the impact of this disease.