Ericksonmccleary4441

The present research is aimed at clarifying meta-analytically the relation of so-called Dark Triad (DT; i.e., narcissism, Machiavellianism, or psychopathy) traits to factor analytic models covering the basic personality space. Unlike recent meta-analyses that investigated such relations at the bivariate level, we used 2-stage structural equation modeling (TSSEM) meta-analysis to explore the full complexity of structural relations between DT traits and the five-factor model (FFM) and HEXACO dimensions, as well as the higher-order personality factors labeled Alpha (or stability) and Beta (or plasticity). MYCi361 nmr Based on pooled matrices, covering k = 108 samples with a total N of 40,818, our findings point to the following major conclusions (a) common elements among DT traits constitute a higher-order factor D that is not covered by Alpha and Beta; (b) no common general factor underlies all 3 higher-order traits; (c) at the dimension level of DT and the FFM, there are cross-loadings from D onto agreeableness and conscientiousness, as well as from Beta onto narcissism; (d) after adding HEXACO dimensions, the higher-order structure remains basically intact, but the low pole of HEXACO honesty-humility becomes an integral part of higher-order D; and (e) moderator analyses of different DT measures largely reveal structural equivalence of original measures of single DT traits with the Short Dark Triad, but less so with the Dirty Dozen DT measure. Overall, the results appear to converge on a coherent picture of several pieces of information on the structure of "dark" and "bright" personality that were previously discussed in a piecemeal fashion. (PsycInfo Database Record (c) 2020 APA, all rights reserved).This study develops and tests a model of the transition from paid employment to entrepreneurship using a sample of 226 adults currently in paid employment. Building on a seminal but largely untested insight from Shapero (1975), we used theoretical logic from event system theory to propose that displacing work events moderate the effect of entrepreneurial identity aspirations, a possible-self role identity, on engagement in nascent entrepreneurial activities (discovery and exploitation behaviors). Results show that entrepreneurial identity aspirations were more strongly positively related to entrepreneurial discovery behaviors among employees who experienced a displacing work event in their current workplace; discovery behaviors in turn related to entrepreneurial exploitation behaviors. The moderation effect was significant for four of the six displacing events examined in this study. Our findings have implications for the literatures on entrepreneurial career transitions, entrepreneurial role identity, and event system theory and offer validity evidence for the nascent entrepreneurial behaviors scale. (PsycInfo Database Record (c) 2020 APA, all rights reserved).We contribute to understanding the previously unrecognized consequences of individualized employment arrangements on the relationship between pay and performance. Increases in the application of pay-for-performance (PFP) idiosyncratic deals (PFP i-deals) raise questions about how individualized PFP arrangements affect the performance of peers who do not receive such customized deals. As pay systems become more individualized, understanding the economic ramifications of how PFP i-deals affect peer performance is essential for understanding the total unit effects of implementing PFP i-deals. To examine these peer effects, we explored peer responses to PFP i-deals and identified boundary conditions on broad theoretical assumptions underlying the conclusion that PFP increases unit performance. We tested our predictions by applying multilevel random-coefficient discontinuous growth models to a sample of 451 peers nested in 117 business units of a for-profit health-care organization. Immediately after PFP i-deal implementation in the unit, the performance level of peers was negatively affected. Additionally, peer performance trends after PFP i-deal implementation were lower than they were before the PFP i-deal implementation. Our study also identified contextual factors that influence peer responses to PFP i-deal implementation. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Computational neuroscience models propose that working memory (WM) involves recurrent excitatory feedback loops that maintain firing over time along with lateral inhibition that prevents the spreading of activity to other feature values. In behavioral paradigms, this lateral inhibition appears to cause a repulsion of WM representations away from each other and from other strong sources of input. Recent computational models of schizophrenia have proposed that reduction in the strength of inhibition relative to strength of excitation may underlie impaired cognition, and this leads to the prediction that repulsion effects should be reduced in people with schizophrenia spectrum disorders (PSZ) relative to healthy control subjects (HCS). We tested this hypothesis in 2 experiments measuring WM repulsion effects. In Experiment 1, 45 PSZ and 32 HCS remembered the location of a single object relative to a centrally presented visual landmark and reported this location after a short delay. The reported location was repelled away from the landmark in both groups, but this repulsion effect was increased rather than decreased in PSZ relative to HCS. In Experiment 2, 41 PSZ and 34 HCS remembered 2 sequentially presented orientations and reported each orientation after a short delay. The reported orientations were biased away from each other in both groups, and this repulsion effect was again more pronounced in PSZ than in HCS. Contrary to the widespread hypothesis of reduced inhibition in schizophrenia, we provide robust evidence from 2 experiments showing that the behavioral performance of PSZ exhibited an exaggeration rather than a reduction of competitive inhibition. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Cholangiocarcinoma (CCA) has a poor prognosis and high chemoresistance. Interleukin-4 receptor (IL-4R) is overexpressed in several cancer cells and plays a crucial role in tumor progression and drug resistance. IL4RPep-1, an IL-4R-binding peptide, has been identified by phage display and used for tumor targeting. In this study, we exploited IL4RPep-1 to guide the tumor-specific delivery of a proapoptotic peptide to chemoresistant CCA, thereby inhibiting tumor growth. Immunohistochemistry of human primary CCA tissues showed that IL-4R levels were upregulated in moderately to poorly differentiated types, and higher levels of IL-4R are correlated with lower survival rates in patients with CCA. IL4RPep-1 was observed to preferentially bind with high IL-4R-expressing KKU-213 human CCA cells, whereas it barely bound with low IL-4R-expressing KKU-055 cells. A hybrid of IL4RPep-1 and a proapoptotic peptide (KLAKLAK)2 (named as IL4RPep-1-KLA) induced cytotoxicity and apoptosis in KKU-213 cells and increased those levels induced by 5-fluorouracil (5-FU).