Erichsenpoole5588

The dataset included 50 VLE images (10 high-grade dysplasia, 40 non-dysplastic BE). VLE images were reviewed in a randomized and blinded fashion by 5 GI trainees with no prior VLE experience and 5 experienced VLE users. Sensitivity, specificity and accuracy of GI trainees was 83.3% (95% CI 71.5-91.7%), 59.0% (95% CI 51.6-66.0%), and 64.8% (95% CI 58.5-70.7%) compared to 80.0% (95% CI 67.7-89.2%), 79.5% (95% CI 73.0-85.0%), and 79.6% (95% CI 74.1-84.4%) for VLE experts respectively. The difference in specificity and accuracy between the two groups were statistically significant with P<0.001.

A brief training session on VLE is inadequate to reach competency in interpretation of VLE by GI trainees. Additional experience is required to accurately interpret VLE images.

A brief training session on VLE is inadequate to reach competency in interpretation of VLE by GI trainees. Additional experience is required to accurately interpret VLE images.

The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asian countries is increasing at concerning level. Currently, no specific treatment available to prevent its oxidative stress and progression except for diet and lifestyle changes. Vitamin E such as tocotrienol-rich fraction (TRF) has a promising potential in preventing NAFLD progression. TRF is a potent antioxidant but has low bioavailability due to the use of long-chain triglycerides (LCT) as its carrier. Testing of potential therapeutic agents such as TRF are commonly carried out using animal models. These animal models are often costly due to limited access to the supply especially Asian countries and predisposed to high transportation cost. Lower expenditure of NAFLD model should be investigated without forfeiting the outcome of study. Therefore, this study addresses the gap by utilizing the ICR mice as NAFLD model through dietary modification and testing on the newly formulated TRF with combination of palm kernel oil (PKO) as a medium-chaiucidate the mechanism of this new TRF formulation in reducing NAFLD progression.

TRF showed promising potential as an agent to reduce NAFLD progression in ICR mice. Further study at gene and protein levels are required to fully elucidate the mechanism of this new TRF formulation in reducing NAFLD progression.The poor nutritional quality of feed resources is one of the major constraints to optimal livestock productivity in Ethiopia. In the current study area, there is lack of information on the chemical composition of major feed resources to quantify their nutritional quality for interventions. The aim of this study was to assess the chemical composition of livestock feed resources (natural pasture, crop residues, local liquor byproduct (atella) and indigenous fodder tree and shrub species) in the medium and low agroecological zones (AEZs) in the mixed farming system of Haru District, Ethiopia. The feed samples were analysed in dry matter basis for ash dry matter (DM), crude protein (CP), acid-detergent fiber (ADF), neutral-detergent fiber (NDF) and ether extractor (EE)). The results revealed that nutrient content of feeds showed variation between the two AEZs. The overall mean DM, Ash, NDF, ADF, EE, and CP content of natural grass species ranged from 91.40 ± 0.84-92.26 ± 0.55 %, 6.88 ± 0.11-12.56 ± 1.04 %, 64.67 , natural pasture grasses and crop residues. It is suggested that the supplementation of the studied IFTS and atella, particularly during the dry season when the quality of natural pasture decreases in CP content would be essential. Urea treatment of crop residues when affordable to improve its nutritional quality would be imperative to enhance livestock performance in the study area and for similar settings.Tamarindus indica L. is a forest plant species widely used in semi-arid regions and has an important socio-economic role. A 90 d greenhouse pot experiment was conducted to evaluate the efficiency of soil amendments with biochar and/or three Arbuscular Mycorrhizal Fungi (AMF) strains; Rhizophagus fasciculatus (Rf), Rhizophagus aggregatus (Ra), and Rhizophagus irregularis (Ri) on T. indica grown under aluminum stress. The amendments consisted of 5% biochar and 20 g kg-1 AMF as (i) control; (ii) biochar; (iii) biochar + Rf; (iv) biochar + Ra; (v) biochar + Ri; (vi) Rf; (vii) Ra; (viii) Ri. The treatments with biochar significantly (P less then 0.05) increased soil pH and reduced the content of soil exchangeable Al3+ relative to the control and exclusive AMF treatments. All the treatments improved total nitrogen and phosphorus uptake by roots and shoot of T. indica and resulted in improved plant growth and root/shoot dry weight. see more The ability of biochar to enhance the soil's water-holding capacity played a key role in improving the intensity of mycorrhization. Overall, biochar amendments significantly improved the photosynthetic potential of T. indica and the activities of antioxidant enzymes compared to other treatments. Thus, the combined effects of enhanced (a) soil physicochemical parameters, (b) mycorrhization, (c) nutrient uptake, (d) photosynthetic potential, and (e) antioxidant activities played an important role in mitigating Al-related stress to improve the growth of T. indica. Therefore, the application of biochar in combination with AMFs can serve as a strategy for ensuring plant biodiversity in acid and Al-toxic soils in arid and semi-arid regions in Africa.In Sub-Saharan Africa, inadequate complementary feeding practices and being nutritionally inadequate are primary factors in infant and young child malnutrition, growth failure, and high morbidity and mortality. Therefore, novel complementary foods need to be developed to alleviate malnutrition problems in IYC. Therefore, this experimental study aimed to assess the effects of newly developed grain-bee larvae blended complementary foods on the growth performance, haematological, and biochemical parameters of BALB/c mice. A complete randomized design was used and a total of 75 BALB/c mice were assigned to each of the five treatments. The treatments were T1 = Casein diet; T2 = 57 % Maize, 29 % Teff, 14 % Soybean; T3 = 58 % Maize, 29 % Teff, 13 % Bee larvae; T4 = Commercial wean mix; and T5 = Basal diet alone. The in vivo experiment trial was done for 28 days along with seven days of adaptation. Dietary intake was not significantly different (P = 0.96) between treatments, but it was noted that T3 had gained the highest final body weight (38.52 g). The examined biochemical parameters showed T4 had the lowest serum protein (6.27 mg/dl) and globulin (3.61 mg/dl). Compared to others, T3 significantly (P less then 0.001) increased WBC (4 × 106 mm3), RBC (11.37 × 103 mm3), Haemoglobin (16.42 g/dl), and Hematocrit (63.04 %). The highest serum levels of zinc (0.55 mg/dl) and iron (2.08 mg/dl) were reported on T2, while the highest serum calcium content (10.64 mg/dl) was reported on T1. The results indicated that T3 can aid body growth, health, and prevent malnutrition in infants and young children.

Bladder cancer (BLCA) is the most common malignant tumor in the genitourinary system, and the complex tumor microenvironment (TME) of BLCA is the main factor in its difficult treatment. Accumulated evidence supports that alternative splicing (AS) events frequently occur in cancer and are closely related to the TME. Therefore, there is an urgent need to comprehensively analyze the prognostic value of AS events in BLCA.

The clinical, transcriptome and AS data of BLCA were downloaded from the Cancer Genome Atlas database, and a Cox proportional hazard regression model and LASSO regression were used to establish a prognostic signature. Then, the prognostic value of the signature was verified by clinical survival status, clinicopathologic features, tumor immune microenvironment (TIME), and immune checkpoint. Next, we screened the AS-related genes with the largest expression differences between tumor and normal samples by gene differential expression analysis. Finally, the regulatory network of AS-splicing factanisms of and personalized immunotherapy for BLCA.Copaiba oleoresin has been related to properties including healing and anti-inflammatory effects, making it a potential candidate to treat oral lesions. We aimed to define the benefits related to the anti-inflammatory and healing capacity of Copaiba-based formulations on the oral cavity. This is a systematic review, conducted in PubMed, Web of Science, Scopus, Embase, Scielo, Cochrane Library, BVS, and Google Scholar databases selecting full articles in English, Portuguese, or Spanish, until March 3rd, 2021. Pre-clinical, clinical, or randomized clinical trials, cohort and case-control in vivo studies were included; studies with other designs, in vitro, and those that did not match the PICO question were excluded (PROSPERO CRD42021244938). Data was collected and synthesized descriptively through a specific form. The risk of bias was evaluated by SYRCLE's RoB Tool. So, five studies were included. Two reported beneficial wound healing effects, such as early reduction in the wound area and greater immature bone formation in the rats' mandibles; and two related benefic anti-inflammatory effects, like reduced acute inflammatory reaction and more advanced tissue repair stage, early formation of collagen fibrils, with greater quantity, thickness and better organization, and more expressive anti-inflammatory activity, reduction of the edema intensity and the CD68 + macrophages concentration. Based on the articles, benefits related to the wound healing and anti-inflammatory effects in the oral cavity of rats treated with Copaiba oleoresin were suggested. However, due to the limited data, future studies are necessary, especially clinical ones.Increased levels of high-sensitivity C-reactive protein (hsCRP) is associated with several psychiatric disorders. Demographic factors such as age and gender might affect this association, but the results are conflicting. The aim of this study was to explore a relationship between age, gender and hsCRP in an acute psychiatric inpatient population. We included 484 patients admitted to an acute psychiatric ward. Based on age distribution percentiles (25%, 50% and 75 %), we categorized patients into three age groups; ≦31 years old, 31-47 years old and ≧ 48 years old. Differences in serum levels of hsCRP between the age groups were assessed in the total sample, within males and females, and within diagnostic groups. There were significant differences in hsCRP across age groups. The effect was stronger in males than females. The significant differences between age groups were kept among patients with substance use disorders and bipolar disorders, but not among schizophrenia spectrum disorders, unipolar depression, neurotic disorders and personality disorders. Our findings suggest that the previously known association between age and hsCRP is present within an acute psychiatric population. However, this association was not found for all psychiatric diagnoses.In developing countries, fermentation is one of the traditional food processing methods for production of relatively safe and nutritious foods. Among many fermented foods in Ethiopia, "Shameta" is one of the locally produced and consumed cereal-based fermented porridge mainly used to support strength and recovery of lactating women after birth. However, even though the product is consumed for years, so far, the nutritional composition and bioactive compounds of the porridge not yet scientifically determined. This study aimed to determine the physicochemical properties, nutritional composition and bioactive compounds of "Shameta" commonly produced and consumed in Western part of the country. A total of 27 "Shameta" samples were collected from houses of lactating mothers residing in different districts of East Wollega zone. Results showed that, "Shameta" sample prepared from blend of maize and barely supplemented with faba bean results in crude protein content of 11.2 g/100g as compared with samples without faba bean, 6.