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01) of patients, and maintained its prognostic value in predicting poor RFS and OS of "Early-stage" HCC patients regardless of clinical features being studied. Multivariate survival analysis was also identified ESE3 as an independent prognostic factor for RFS (p = 0.05 for marginal significance) and OS (p = 0.031). ESE3 expression restoration in cells led to a significant inhibition in HepG2 cell proliferation in vitro and vivo (both p  less then  0.001). CONCLUSIONS Down-regulated ESE3 expression in HCC tissues could serve as a potential therapeutic target against HCC and appears to be as a poor prognostic indicator for prognosis, especially in "Early-stage" HCC patients.Maternal depression is a risk factor for the development of problem behavior in children. Although food insecurity and housing instability are associated with adult depression and child behavior, how these economic factors mediate or moderate the relationship between maternal depression and child problem behavior is not understood. The purpose of this study was to determine whether food insecurity and housing instability are mediators and/or moderators of the relationship between maternal depression when children are age 3 and children's problem behaviors at age 9 and to determine whether these mechanisms differ by race/ethnicity. We used data from the Fragile Families and Child Wellbeing Study. Food insecurity and housing instability at age 5 were tested as potential mediators and moderators of the relationship between maternal depression status at age 3 and problem behavior at age 9. A path analysis confirmed our hypothesis that food insecurity and housing instability partially mediate the relationship between maternal depression when children are age 3 and problem behavior at age 9. However, housing instability was only a mediator for externalizing problem behavior and not internalizing problem behavior or overall problem behavior. Results of the moderation analysis suggest that neither food insecurity nor housing instability were moderators. None of the mechanisms explored differed by race/ethnicity. While our findings stress the continued need for interventions that address child food insecurity, they emphasize the importance of interventions that address maternal mental health throughout a child's life. Given the central role of maternal health in child development, additional efforts should be made to target maternal depression.Peanut red spider mite, Tetranychus ogmophallos, exhibits a peculiar dispersal behavior using silk balls, which involves clustering of mites and spinning of webs at the top of plants. Such a dispersal mechanism has not been studied for this species yet. Therefore, this study aimed at using mathematical models to describe aerial dispersal and silk ball formation of peanut red spider mite on peanut plants. The influence of wind speed, generated by a wind tunnel, on the dispersal of mites was studied in two experiments, one with 500 mites per plant and one with 1000 mites per plant, and six wind speeds (5, 10, 15, 20, 25, and 30 km h-1) for each mite density. The proportion of displaced mites and the distance they were blown were measured. Another series of experiments considered the formation of silk balls to assess how fast balls were formed as a function of time and the number of mites present on a peanut plant. Data from the wind tunnel experiments were analyzed by logistic regression and multiple regressiontion of dispersal distances. The models describing silk ball formation also described data very well. Ball size was found to increase almost linearly with the number of mites found in the ball. We expect that the knowledge provided by the present study will help to develop efficient management strategies against T. ogmophallos in peanut crops as dispersal seems to be a key factor in the species' capability to become a serious pest.Shifting of trophic niches of soil microarthropods may allow them to adapt to changing resource conditions as induced by global change processes. However, the capability of microarthropods to shift their trophic niches is little studied. Whereas some studies based on stable isotopes (15N/13C) point to distinct and narrow trophic niches, others indicate that trophic niches are plastic. Here, we investigated shifts in trophic niches of oribatid mites (Oribatida, Acari), a major soil detritivore microarthropod group, due to forest management, i.e., plantation of beech and spruce forests in Central Europe, using neutral lipid fatty acid (NLFA) markers. Due to differential microbial communities, we expected a fungi-based diet of oribatid mites in beech forest, but more bacterial contributions to the diet in spruce forest. Supporting these hypotheses, NLFA markers indicated that the trophic niches of each of the studied oribatid mite species differed between beech and spruce forests and shifted from feeding predominantly on litter and fungi in beech forest to more intensively feeding on bacteria in spruce forest. Oribatid mite species with the most pronounced differences in trophic niches included Achipteria coleoptrata, Eupelops hirtus, Eupelops plicatus and Liacarus xylariae, which had been classified as primary or secondary decomposers in previous studies. Overall, the results indicate that the ability of oribatid mite species to colonize different habitats and ecosystems is due to their ability to adjust their diet, i.e., to trophic plasticity. Changes in trophic niches in each of the studied oribatid mite species suggest that detritivores in soil may better cope with future changes in environmental conditions and associated changes in resource composition than species above the ground.Compared with other ethnic groups, Asian Americans report the lowest rates of mental health treatment and service utilization. This is true even among Asian Americans with mental illness, which indicates that the underutilization of mental health services is not due to the low prevalence of mental health disorders in this population. selleckchem This study examined which sociodemographic factors, types of mental health problems, and barriers to treatment were associated with the treatment receipt among 126 Asian Americans who reported perceived mental health problems. Among sociodemographic factors, Chinese ethnicity and advanced English proficiency were associated with increased treatment receipt. Controlling for demographic variables, mental health problems such as psychosis, depression, and a history of abuse or trauma significantly increased the likelihood of receiving treatment, whereas addiction showed a tendency of decreased treatment receipt. Among reported barriers, difficulty finding a culturally appropriate therapist appeared to be an important barrier among Asian Americans with perceived mental health problems.Medication for opioid use disorder (MOUD) is a key strategy for addressing the opioid use disorder crisis, yet gaps in MOUD provision impede this strategy's benefits. The research reported here sought to understand what distinguishes low- and high-performing organizations in building and using capacity to provide MOUD. As part of a mixed methods MOUD implementation trial, semi-structured telephone interviews were conducted with personnel from low- and high-performing MOUD-providing organizations. Seventeen individuals from 17 organizations were interviewed. Findings demonstrate the importance of individual, organization, and community-level factors in supporting the building and use of MOUD capacity. Low- and high-performing organizations showed different patterns of facilitators and barriers during the implementation process. The key difference between low- and high-performing organizations was the level of organizational functioning. A better understanding of an organization's assets and deficits at the individual, organizational, and community levels would allow decision-makers to tailor their approaches to MOUD implementation.Individuals with substance use disorders (SUDs) who engage in post-withdrawal management (or detoxification) continuing care are more likely to remain drug free or sober and less likely to be incarcerated or die of overdose. Yet, just 21-35% of individuals receiving emergency withdrawal management services receive continuing care. This deficiency is occurring, while overdose rates are high, and limited evidence exists on how to improve this vital transition. To address this gap, withdrawal management service providers employed the LINK Care Transition Implementation System to improve withdrawal management to continuing care transition rates. This system integrates three evidence-based implementation science approaches (a) practice bundle, (b) process checklist, and (c) standardized organizational change model. This integrated implementation approach improved withdrawal management to continuing care transition rates from 20 (baseline average) to 43% (post-intervention) in (n = 6) Wisconsin withdrawal management centers. This study provides insights into how to improve transitions to enhance SUD care and outcomes.BACKGROUND Lower urinary tract symptoms (LUTS), often secondary to benign prostatic hyperplasia, are a common problem for older men. Lifestyle factors, including physical activity and sedentariness, may be important LUTS risk factors and suitable targets for intervention. OBJECTIVE To determine whether physical activity and sedentariness are associated with LUTS incidence and progression. DESIGN The Health Professionals Follow-up Study is a prospective cohort of men that began in 1986. Follow-up for LUTS is complete through 2008. PARTICIPANTS Men aged 40-75 years at enrollment and members of health professions. MAIN MEASURES Total weekly metabolic equivalent of task (MET)-hour scores were calculated and were categorized ( less then  9, 9 to less then  21, 21 to less then  42, 42 to less then  63, ≥ 63 MET-hours/week). Participants reported their average time/week spent sitting watching television as a measure of sedentariness, which was categorized ( less then  1, 1-3, 4-10, 11-29, ≥ 30 h/week). Participanand BMI. Physical inactivity and sedentariness were not associated with LUTS worsening. Increasing physical activity and reducing sedentariness may be strategies for preventing LUTS in addition to their well-established benefits for other diseases.Diffuse hepatic diseases have a variety of etiologies, with each showing characteristic morphometric changes. These changes are closely related to micro- and macro-level intrahepatic hemodynamics, in addition to the specific underlying pathophysiology. Short-term disorders in intrahepatic hemodynamics caused by each pathophysiological condition are compensated for by the balance of blood perfusion systems using potential trans-sinusoidal, transversal, and transplexal routes of communication (micro-hemodynamics), while long-term alterations to the intrahepatic hemodynamics result in an increase in total hepatic vascular resistance. Blood flow disorders induced by this increased vascular resistance elicit hepatic cellular necrosis and fibrosis. These changes should be uniformly widespread throughout the whole liver. However, morphometric changes do not occur uniformly, with shrinkage or enlargement not occurring homogeneously. Against this background, several macro-intrahepatic hemodynamic effects arise, such as asymmetrical and complicating morphometric structures of the liver, intricate anatomy of portal venous flow and hepatic venous drainage, and zonal differentiation between central and peripheral zones.