Enevoldsencase8149

The findings were adjusted for the significant influencing factor size of pre-operative radiolucency (p < 0.05). Of the 109 teeth that were initially accessed through existing crowns, 9 (8%) displayed porcelain fracture or crown de-cementation.

Performing root canal treatment through an existing full coverage restoration did not compromise periapical healing and was associated with a low incidence of associated complications.

Crown removal before NSRCT is not mandatory for periapical healing but requires a judicious pre-assessment of current and future marginal and restorative integrity.

Crown removal before NSRCT is not mandatory for periapical healing but requires a judicious pre-assessment of current and future marginal and restorative integrity.

To provide a systematic review of the literature on studies comparing the immunoprofile of nevoid basal cell carcinoma syndrome (BCNS)-associated and sporadic odontogenic keratocysts (OKCs), in order to identify markers that could accurately distinguish the two OKC subtypes.

We searched MEDLINE/Pubmed, Web of Science, EMBASE via OVID, and grey literature for publications until December 28th, 2019, that compared the immunohistochemical expression of the two OKC subtypes. The studies were qualitatively assessed using the Critical Appraisal Tool for Case Series (Joana Briggs Institute). Sensitivity and specificity, positive and negative likelihood ratio, diagnostic odds ratio and area under the curve, and pooled estimates were calculated, using a random-effects model.

Seventy-one studies were qualitatively analyzed; 61 markers were evaluated in one study and 32 in ≥ 2 studies. Twenty-five studies reported differential expression of 29 markers in the form of higher number of positive cells or greater staining intensity usuallyin BCNS-associated OKCs. Meta-analysis for bcl-2, Cyclin D1, CD56, CK18, p53, and PCNA showed that none of those markers is distinguishable between BCNS-associated and sporadic OKCs, in a 95% confidence interval. The risk of bias was high in 34 studies, moderate in 22, and low in 15.

The present systematic review and meta-analysis uncovered that, although several immunohistochemical markers might characterize the OKC phenotype, they cannot discriminate between the BCNS-associated and sporadic OKCs.

This study highlighted the requirement for additional screening for markers by immunohistochemistry, preferentially coupled to alternative diagnostic applications such as genomics technologies.

This study highlighted the requirement for additional screening for markers by immunohistochemistry, preferentially coupled to alternative diagnostic applications such as genomics technologies.Pathogen transmission is a major limit of social species. click here Social distancing, a behavioural-based response to diseases, has been regularly reported in nature. However, the identification of distinctive stimuli associated with an infectious disease represents a challenging task for host species, whose cognitive mechanisms are still poorly understood. Herein, the social fish Paracheirodon innesi, was selected as model organism to investigate animal abilities in exploiting visual information to identify and promote social distancing towards potentially infected conspecifics. To address this, a robotic fish replica mimicking a healthy P. innesi subject, and another mimicking P. innesi with morphological and/or locomotion anomalies were developed. P. innesi individuals were attracted by the healthy fish replica, while they avoided the fish replica with morphological abnormalities, as well as the fish replica with an intact appearance, but performing locomotion anomalies (both symptoms associated with a microsporidian parasite infesting P. innesi and other fish). Furthermore, the fish replica presenting both morphology and locomotion anomalies in conjunction, triggered a significantly stronger social distancing response. This confirms the hypothesis that group living animals overgeneralize cues that can be related with a disease to minimize transmission, and highlights the important role of visual cues in infection risk contexts. This study prompts more attention on the role of behavioural-based strategies to avoid pathogen/parasite diffusion, and can be used to optimize computational approaches to model disease dynamics.

This study evaluated (i) the relationship between oxygen uptake ([Formula see text]O

) kinetics and maximal [Formula see text]O

([Formula see text]O

) within groups differing in fitness status, and (ii) the adjustment of [Formula see text]O

kinetics compared to that of central [cardiac output (Q̇), heart rate (HR)] and peripheral (deoxyhemoglobin over [Formula see text]O

ratio ([HHb]/[Formula see text]O

)] O

delivery, during step-transitions to moderate-intensity exercise.

Thirty-six young healthy male participants (18 untrained; 18 trained) performed a ramp-incremental test to exhaustion and 3 step-transitions to moderate-intensity exercise. Q̇ and HR kinetics were measured in 18 participants (9 untrained; 9 trained).

No significant correlation between τ̇[Formula see text]O

and [Formula see text]O

was found in trained participants (r = 0.29; p > 0.05) whereas a significant negative correlation was found in untrained (r = - 0.58; p < 0.05) and all participants (r = - 0.82; p < 0.ants.

 0.05) CONCLUSION The results indicated that when comparing participants of different fitness status (i) there is a point at which greater V̇O2max values are not accompanied by faster [Formula see text]O2 kinetics; (ii) central delivery of O2 does not seem to limit the kinetics of [Formula see text]O2; and (iii) O2 delivery within the active tissues might contribute to the slower [Formula see text]O2 kinetics response in untrained participants.

For optimizing the quality of repeated-sprint training in hypoxia, the differences in the acute performance responses to a single session of repeated-sprint exercise with various (i) inspired oxygen fractions; (ii) exercise-to-recovery (ER) ratios and (iii) recovery modalities were examined.

Ten male participants performed three sets, 5 × 5-s all-out treadmill sprints, ER ratio of 15, passive recovery, in seven trials randomly. In four of the seven trials, hypoxic levels were set corresponding to sea level (SL

), 1500 (1.5K

), 2500 (2.5K

), and 3500m (3.5K

), respectively. In a further two trials, the hypoxic level of 3.5K

was maintained, while the ER ratio was reduced to 14 (3.5K

) and 13 (3.5K

), respectively. In the last trial, the passive recovery mode of 3.5K

was changed to active (3.5K

).

In comparison to SL

, the averaged peak velocity (P-Vel), mean velocity (M-Vel), and velocity decrement score (Sdec) of the sprints, and the cumulative HR-based training impulse (cTRIMP) in 1.5K

and 2.