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The JPEG is one of the most widely used lossy image-compression standards, whose compression performance depends largely on a quantization table. In this work, we utilize a Convolutional Neural Network (CNN) to generate an image-adaptive quantization table in a standard-compliant way. We first build an image set containing more than 10,000 images and generate their optimal quantization tables through a classical genetic algorithm, and then propose a method that can efficiently extract and fuse the frequency and spatial domain information of each image to train a regression network to directly generate adaptive quantization tables. In addition, we extract several representative quantization tables from the dataset and train a classification network to indicate the optimal one for each image, which further improves compression performance and computational efficiency. Tests on diverse images show that the proposed method clearly outperforms the state-of-the-art method. Compared with the standard table at the compression rate of 1.0 bpp, the regression and classification network provide average Peak Signal-to-Noise Ratio (PSNR) gains of nearly 1.2 and 1.4 dB. For the experiment under Structural Similarity Index Measurement (SSIM), the improvements are 0.4% and 0.54%, respectively. The proposed method also has competitive computational efficiency, as the regression and classification network only take 15 and 6.25 milliseconds, respectively, to process a 768 W 512 image on a single CPU core at 3.20 GHz.Person re-identification (re-ID) has attracted much attention recently due to its great importance in video surveillance. In general, distance metrics used to identify two person images are expected to be robust under various appearance changes. However, our work observes the extreme vulnerability of existing distance metrics to adversarial examples, generated by simply adding human-imperceptible perturbations to person images. Hence, the security danger is dramatically increased when deploying commercial re-ID systems in video surveillance. Although adversarial examples have been extensively applied for classification analysis, it is rarely studied in metric analysis like person re-identification. The most likely reason is the natural gap between the training and testing of re-ID networks, that is, the predictions of a re-ID network cannot be directly used during testing without an effective metric. In this work, we bridge the gap by proposing Adversarial Metric Attack, a parallel methodology to adversarial classification attacks. Comprehensive experiments clearly reveal the adversarial effects in re-ID systems. Meanwhile, we also present an early attempt of training a metric-preserving network, thereby defending the metric against adversarial attacks. At last, by benchmarking various adversarial settings, we expect that our work can facilitate the development of adversarial attack and defense in metric-based applications.Spectral computed tomography is able to provide quantitative information on the scanned object and enables material decomposition. Traditional projection-based material decomposition methods suffer from the nonlinearity of the imaging system, which limits the decomposition accuracy. Inspired by the generative adversarial network, we proposed a novel parallel multi-stream generative adversarial network (PMS-GAN) to perform projection-based multi-material decomposition in spectral computed tomography. By designing the differential map and incorporating the adversarial network into loss function, the decomposition accuracy was significantly improved with robust performance. The proposed network was quantitatively evaluated by both simulation and experimental study. The results show that PMS-GAN outperformed the reference methods with certain robustness. Compared with Pix2pix-GAN, PMS-GAN increased the structural similarity index by 172% on the contrast agent Ultravist370, 11% on bones, and 71% on bone marrow, respectively, in a simulated test scenario. In an experimental test scenario, 9% and 38% improvements of the structural similarity index on the biopsy needle and on a torso phantom were observed, respectively. The proposed network demonstrates its capability of multi-material decomposition and has certain potential toward clinical applications.One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct undersampled PAM images and transcend the trade-off between spatial resolution and imaging speed. We compared various convolutional neural network (CNN) architectures, and selected a Fully Dense U-net (FD U-net) model that produced the best results. To mimic various undersampling conditions in practice, we artificially downsampled fully-sampled PAM images of mouse brain vasculature at different ratios. This allowed us to not only definitively establish the ground truth, but also train and test our deep learning model at various imaging conditions. Our results and numerical analysis have collectively demonstrated the robust performance of our model to reconstruct PAM images with as few as 2% of the original pixels, which can effectively shorten the imaging time without substantially sacrificing the image quality.Semi-Supervised Learning (SSL) is an approach to machine learning that makes use of unlabeled data for training with a small amount of labeled data. LY2157299 order In the context of molecular biology and pharmacology, one can take advantage of unlabeled data. For instance, to identify drugs and targets where a few genes are known to be associated with a specific target for drugs and considered as labeled data. Labeling the genes requires laboratory verification and validation. This process is usually very time consuming and expensive. Thus, it is useful to estimate the functional role of drugs from unlabeled data using computational methods. To develop such a model, we used openly available data resources to create (i) drugs and genes, (ii) genes and disease, bipartite graphs. We constructed the genetic embedding graph from the two bipartite graphs using Tensor Factorization methods. We integrated the genetic embedding graph with the publicly available genetic interaction graphs. Our results show the usefulness of the integration by effectively predicting drug labels.

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